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26 Jun 2024: RPE-1) cell line activate p53, causing cell growth arrest and DNA repair via the NHEJ pathway. ... A delicate balance is required, however, as p53 inhibition can leave cells vulnerable to tumorigenic mutations.

23 Feb 2024: School of Clinical Medicine. Featured Articles. Therapeutic vulnerabilities in lung tumours with distinct p53 deficiencies. ... Importantly, the authors identified a similar p53-mutation type specific gene expression signature in human lung tumors.

25 Jun 2024: Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: The Y220X Paradigm. ... 2019). 21,. 5. (doi:A Structure-Guided Molecular Chaperone Approach for Restoring the Transcriptional Activity of the p53 Cancer Mutant Y220C.

25 Jun 2024: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... We discovered that about 30% of oncogenic mutants of p53 are just temperatures sensitive and can, in theory, be rescued by small molecules.

26 Jun 2024: I. (2013). Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy. ... 2011). Validation of MdmX as a therapeutic target for reactivating p53 in tumors.

26 Jun 2024: Long term aggresome accumulation leads to DNA damage, p53-dependent cell cycle arrest, and steric interference in mytosis, J.

26 Jun 2024: Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis.

26 Jun 2024: 2016) Mechanical cell competition kills cells via induction of lethal p53 levels.

26 Jun 2024: S. Itzhaki, and D. R. Spring. Functionalized double strain-promoted stapled peptides for inhibiting the p53-MDM2 interaction. ... S. Verma, and L. S. Itzhaki. Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2.

26 Jun 2024: The net result is hyperplasia in several tissues, which is exacerbated by the additional loss of the tumour suppressor protein p53. ... p53 is non-functional in the majority of human tumours and mice lacking p53 are prone to tumour development.

25 Jun 2024: D Klenerman. – eLife. Characterization of full-length p53 aggregates and their kinetics of formation.

23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Dr Rana's Group. Welcome to Rana Lab. Research. The role of TGF-beta superfamily signalling

26 Jun 2024: p53 mutant progenitors colonize normal epidermis Cell Stem Cell 23(5)/2018 DOI: 10.1016/j.stem.2018.08.017.

26 Jun 2024: Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane. ... Genomic instability in mutant p53 cancer cells upon entotic engulfment.

26 Jun 2024: Owen. 1996. R.J.A. Grand, D. Owen, S.M. Rookes & P.H. Gallimore (1996) "Control of p53 expression by Adenovirus-12 early region 1A and early region 1B 54K proteins" ... Levine & Gallimore, P.H. (1995) "The high levels of p53 present in Adenovirus early

25 Jun 2024: Imaging aggregates of P53 and determining the role of these aggregates in the development and spreading of cancer.

26 Jun 2024: CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response. Nat. Med., 24(7):927-930.

26 Jun 2024: ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.

25 Jun 2024: Nat Neurosci. (2022). 25,. 1582. (doi: 10.1038/s41593-022-01206-2). Characterization of full-length p53 aggregates and their kinetics of formation.

26 Jun 2024: I also study transcription factors that play a key role in cancer such as p53 and MYC.