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The Vendruscolo Laboratory
www-vendruscolo.ch.cam.ac.uk/research.html28 Feb 2023: The endogenous proteins that are sequestered by the aggregates share distinct physicochemical properties: They are relatively large in size and significantly enriched in predicted unstructured regions, features that are strongly linked -
Extracellular protein homeostasis in neurodegenerative diseases
www-vendruscolo.ch.cam.ac.uk/Wilson-2023-NRN.pdf28 Feb 2023: Overexpression of wild-type transthyre-tin in the APP23 mouse model of AD reduced cognitive and motor impairments, whereas silencing of the endogenous transthyretin gene promoted neuropathology76. ... Inspired by this mechanism, endogenous internal-izing -
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience …
www-vendruscolo.ch.cam.ac.uk/Joshi-2023-ACSCN.pdf2 Mar 2023: We tested human endogenous fat-soluble(red) and water-soluble (blue) vitamin metabolites in a ThT-basedscreen to identify vitamin metabolites that either accelerate or delaythe aggregation of Aβ42. ... Togetherwith the C. elegans experiments, these data -
1 MRC Toxicology Unit- History 1947- The Toxicology Unit ...
https://www.mrc-tox.cam.ac.uk/files/mrc_toxicology_unit_history.pdf6 Mar 2023: degrees of alkylation by endogenous agents such as those from lipid peroxidation. ... causal molecular mechanisms of external and endogenous toxic agents with adverse outcomes. -
#CamFest Speaker Spotlight
https://www.cam.ac.uk/stories/cambridge-festival-spotlights/alpar-lazar20 Mar 2023: stimuli. However, during sleep, the brain returns to a default state where neurons, mostly undisturbed by intrinsic and extrinsic factors, start communicating in their own ‘endogenous’ language as reflected by unique -
McMahon Group publications
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/papers.html20 Mar 2023: Endogenous GRAF1a was found on lipid droplets in oleic-acid-fed primary glial cells. -
A report prepared for the Donor JUNE 2021 Centre ...
https://www.trophoblast.cam.ac.uk/files/ctr_2020-2021_report_public_reduced.pdf20 Apr 2023: Stem Cell Reports. doi:10.1016/j.stemcr.2020.04.009. 7CTR report. Courtney Hanna showed how endogenous retroviral insertions regulate imprinting of genes in the extra-embryonic tissues. ... Hanna et al (2019). Endogenous retroviral insertions drive -
A report prepared for the Donor JUNE 2021 Centre ...
https://www.trophoblast.cam.ac.uk/files/ctr_2020-2021_report_public_reduced.pdf20 Apr 2023: Stem Cell Reports. doi:10.1016/j.stemcr.2020.04.009. 7CTR report. Courtney Hanna showed how endogenous retroviral insertions regulate imprinting of genes in the extra-embryonic tissues. ... Hanna et al (2019). Endogenous retroviral insertions drive -
https://risk-studies-viewpoint.blog.jbs.cam.ac.uk/tag/interstate-confl…
https://risk-studies-viewpoint.blog.jbs.cam.ac.uk/tag/interstate-conflict/feed/17 May 2023: We estimate that endogenous financial crises are the biggest destroyers of capital, followed closely by interstate conflicts, then pandemics, natural disasters, and then cyber catastrophes./p pThe Centre’s research programme -
https://risk-studies-viewpoint.blog.jbs.cam.ac.uk/tag/social-unrest/fe…
https://risk-studies-viewpoint.blog.jbs.cam.ac.uk/tag/social-unrest/feed/17 May 2023: We estimate that endogenous financial crises are the biggest destroyers of capital, followed closely by interstate conflicts, then pandemics, natural disasters, and then cyber catastrophes./p pThe Centre’s research programme
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