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SRI activities showcased at Science Hackday PDX | Engineering Biology …
https://www.engbio.cam.ac.uk/news/sri-activities-showcased-pdx23 Jul 2024: Projects included an orca sound ocean simulator, numerous artistic projects such as a DNA helix light and programmed light installation displaying the p53 sequence, sensors, drones and more. -
Publications | Biological Physics & Mechanics
www.damtp.cam.ac.uk/research/biophys/publications?page=2723 Jul 2024: 973. (doi: 10.1007/s11538-009-9479-6). Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia. -
Dr Vaithish Velazhahan | Gonville & Caius
https://www.cai.cam.ac.uk/people/dr-vaithish-velazhahan20 Jul 2024: and Schrick, K., 2020. Dietary flavonoid fisetin binds human SUMO1 and blocks sumoylation of p53. -
Dr Mattia Frontini | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/directory/mfrontini23 Feb 2024: Interaction between the Cockayne syndrome B and p53 proteins: implications for aging. ... CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination. -
spongistatin 1
https://www-jmg.ch.cam.ac.uk/data/molecules/polyketides/spongistatin.html18 Jul 2024: s66;P5;P57;P53;P52;P50;P24;N8;s3;s76;d76;N15;s79;N17;N29;N24;s82;s84;d84;/rC:-.3572,3.7125,0;-.3572,2.8875,0;1.0717,2. -
Professor Brian Huntly | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/people/pi/huntly23 Feb 2024: In association with an alteration of the DNA damage response mediated through suboptimal Crebbp acetylation of p53, DNA double strand breaks accumulate and accompanied by a relative decrease in apoptosis, lead -
Graduate Poster Display | Pembroke
https://www.pem.cam.ac.uk/college/news/graduate-poster-display19 Jul 2024: Chiba Ene (PhD Medical Sciences) - Histone demethylase Jumonji D3 (JMJD3) as a Tumor Suppressor by Regulating p53 Activity through Lysine Demethylation. -
Research - Professor Marciniak's Group
https://www.med.cam.ac.uk/marciniak/research/23 Feb 2024: Marciniak. 2013. p53 and Translation Attenuation Regulate Distinct Cell Cycle Checkpoints during Endoplasmic Reticulum (ER) Stress. -
Publications | Knowles Lab
https://www-knowles.ch.cam.ac.uk/publications23 Jul 2024: Journal: Scientific Reports 12 (1). ------------------------------. Characterization of full-length p53 aggregates and their kinetics of formation. -
Ingo Ringshausen | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/directory/ingo-ringshausen23 Feb 2024: Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. ... Cancer Cell, 2006. 10(6): p. 501-14 PMID:17157790. Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI The pathological response to DNA damage does not -
Protein engineering pioneer awarded Royal Society Copley Medal |…
https://www.ch.cam.ac.uk/news/protein-engineering-pioneer-awarded-royal-society-copley-medal23 Jul 2024: His work is now focussed on how mutation affects proteins in the cell cycle, particularly the tumour suppressor p53 – the so-called “Guardian of the Genome” – in order to design novel -
Publications - Kaser Group
https://www.med.cam.ac.uk/kaser/publications/23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Kaser Group. Publications. Reviews & Editorials. 2024 University of Cambridge. -
Aims and Objectives | Department of Biochemistry
https://www.bioc.cam.ac.uk/teaching/fourth-year/biochemistry/guidance23 Jul 2024: Cancer studies. Including cell cycle and cancer, use of mouse models, genome-wide sequencing and genome-wide disease association, leukaemia, p53, cancer therapeutics, recombinant antibody generation, commercial drug design and development, -
Publications
https://www-neurosciences.medschl.cam.ac.uk/horvathlab/publications/23 Feb 2024: RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels. -
Florian T. Merkle - Institute of Metabolic Science-Metabolic Research …
https://www.mrl.ims.cam.ac.uk/research/principal-investigators/florian-t-merkle/23 Feb 2024: For example, hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation from transplanted cells (Merkle ... Human pluripotent stem cells -
Dr Suzanne Dawn Turner | Cambridge Immunology Network
https://www.immunology.cam.ac.uk/Networkdirectory/sdturner23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... Merkel, O., Morrigl, R.,Turner, S.D. and Kenner, L. (2017) When the -
Protein and Nucleic Acid Chemistry - MRC Laboratory of Molecular…
https://www2.mrc-lmb.cam.ac.uk/research/protein-and-nucleic-acid-chemistry/20 May 2024: Alan Fersht - Tumour suppressor p53 structure and drug discovery. -
Professor Sir David Klenerman FMedSci FRS | Yusuf Hamied Department…
https://www.ch.cam.ac.uk/person/dk1001223 Jul 2024: Imaging aggregates of P53 and determining the role of these aggregates in the development and spreading of cancer. -
Jussi Taipale | Department of Biochemistry
https://www.bioc.cam.ac.uk/research/taipale23 Jul 2024: CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response. Nat. Med., 24(7):927-930. -
Katy Brown, PhD | Bioinformatics Training
https://bioinfotraining.bio.cam.ac.uk/staff/katy-brown-phd23 Jul 2024: Contributors: Ingrida Olendraite; Katherine Brown; Andrew E. Firth. A novel map of human p53 response elements uncovers evidence of selection pressures and variants similar to Li-Fraumeni Syndrome mutations. ... Germline and Somatic Genetic Variants in
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