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23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... Merkel, O., Morrigl, R.,Turner, S.D. and Kenner, L. (2017) When the

23 Feb 2024: In association with an alteration of the DNA damage response mediated through suboptimal Crebbp acetylation of p53, DNA double strand breaks accumulate and accompanied by a relative decrease in apoptosis, lead

23 Feb 2024: p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress.

26 Jul 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and

3 Jan 2024: p53 : the gene that cracked the cancer code.

23 Feb 2024: {"id":26,"date":"2011-03-01T14:00:13","date_gmt":"2011-03-01T14:00:13","guid":{"rendered":"http://www.med.cam.ac.uk/infectious-diseases/?page_id=26"},"modified":"2015-01-12T14:44:42","modified_gmt":"2015-01-12T14:44:42","slug":"publications","status"

20 May 2024: Alan Fersht - Tumour suppressor p53 structure and drug discovery.

27 Jul 2024: p53 in the response to environmental stressors.

23 Feb 2024: consequence of p53 stabilization in response to ribosomal stress.

9 Jul 2024: The best students got this correct. Many students also thought the protein, p53 had disulphide bridges. ... p53 was covered in the lectures as a nuclear protein that bound DNA so they should have been aware it is in a reducing environment.

23 Feb 2024: Published in The Lancet Oncology, researchers evaluated the role of the Cytosponge atypia, p53 overexpression, and clinical risk factors (age, sex, and segment length) to prioritise patients for endoscopy.

23 Feb 2024: {"id":26,"date":"2011-03-01T14:00:13","date_gmt":"2011-03-01T14:00:13","guid":{"rendered":"http://www.med.cam.ac.uk/infectious-diseases/?page_id=26"},"modified":"2015-02-06T11:14:05","modified_gmt":"2015-02-06T11:14:05","slug":"publications","status"

23 Feb 2024: 2018) Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations.

23 Feb 2024: Swigart, and G.I. Evan. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. ... Finch, L.B. Swigart, and G.I. Evan. Thepathological response to DNA damage does not contribute to p53-mediated tumour suppression.

29 Jan 2024: Chin, W. Fischle, S.M. Gasser. EMBO J. 2011. 30: 2610-2621. (53) Acetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration.

27 Jul 2024: Department of Pharmacology - Academic Staff https://www.phar.cam.ac.uk/directory/academicstaff An A-Z directory of all Department members can be found here. The Department provides contact details for all members of the Department. Please follow the

27 Jul 2024: Simulations reveal that different responses to cell crowding determine the expansion of p53 and Notch mutant clones in squamous epithelia.

23 Feb 2024: Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1. ... Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell

23 Feb 2024: By contrast, overactivity of Bcl11a is known to cause lymphomas. One member of the Bcl11a network is p53, known to be important in controlling cell division and, when mutated, important in ... If p53 also is inactivated in mice that lack Bcl11a, some

26 Jul 2024: He hates collars, takes no milk in his tea through fear of dead flies, and is a confirmed Peripatetic after bump-suppers” (Chanticlere, Lent Term 1909, p53 and p37 respectively).

23 Feb 2024: Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation.

23 Feb 2024: P53 Epidemiological evidence to support a tax on Sugar Sweetened Drinks as a measure to address childhood obesity.

23 Feb 2024: and Denizot Y., 2012, Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53+/- mice and c-myc-3'RR/Cdk4R24C mice: differential oncogenic mechanisms but similar cellular origin. ... Magnone V., Cogné M. and Denizot Y., 2011, A p53 defect sensitizes

23 Feb 2024: Marciniak. 2013. p53 and Translation Attenuation Regulate Distinct Cell Cycle Checkpoints during Endoplasmic Reticulum (ER) Stress.

22 Jul 2024: xxii] T. Jackson, Post Growth Life after Capitalism, (polity, 2021) p53.

23 Feb 2024: Cambridge Cardiovascular - Functional Genomics https://www.cardiovascular.cam.ac.uk/directory/research-themes/functional-genomics Functional Genomics theme led by Prof Nicole Soranzo performs epigenomic annotation of cells relevant to the

23 Feb 2024: Expression of Fbxo7 in haematopoietic progenitor cells cooperates with p53 loss to promote lymphomagenesis.

27 Jul 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and

23 Feb 2024: p53 is a Direct Transcriptional Target of MYCN in Neuroblastoma. Cancer Res.

15 Jun 2024: Simons. doi:10.1016/j.stem.2010.05.017. Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia.

23 Feb 2024: A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome.

30 Apr 2024: Ras) and tumour suppression proteins (e.g. p53, p16/p19ARF or p21) (for review see Hynds et al., 2022; Wang et al., 2022).

12 Jul 2024: Firth</div> </div> </div> <hr /></div> <h4 class="work-title orc-font-body ng-star-inserted" header="">A novel map of human p53 response elements uncovers evidence of selection pressures and ... 084X </a></div> </div> </div> <hr /></div> <h4

23 Feb 2024: P, Aden K.u00a0/spanEpithelial X-Box Binding Protein 1 Coordinates Tumor Protein p53-Driven DNA Damage Responses and Suppression of Intestinal Carcinogenesis.u00a0span class="docsum-journal-citation

12 Jul 2024: Bioinformatics Training - Cholera Genomics https://bioinfotraining.bio.cam.ac.uk/subjects/cholera-genomics Cholera Genomics en Sebastian Bruchmann, PhD https://bioinfotraining.bio.cam.ac.uk/staff/sebastian-bruchmann-phd <div class="field

23 Feb 2024: and McKenzie, A.N.J. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q. –.

23 Feb 2024: Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner” Mol Cell.

27 Jul 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and

3 Apr 2024: Fischle, S.M. Gasserem. /em/p p(53)strongAcetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration./strongbr / a

23 Feb 2024: Tweddle DA.<br /> p53 is a Direct Transcriptional Target of MYCN in Neuroblastoma.<br /> Cancer Res.

23 Feb 2024: Cambridge Immunology Network - Department of Medicine https://www.immunology.cam.ac.uk/departments/medicine en Professor Ravindra Gupta https://www.immunology.cam.ac.uk/staff/professor-ravindra-gupta <div class="field field-name-field-sd-consultancy

23 Feb 2024: Cambridge Immunology Network - Autoimmunity and inflammation https://www.immunology.cam.ac.uk/Networkdirectory/research-themes/autoimmunity-inflammation Investigating the causes of excessive and aberrant immune responses which result in inflammation

23 Feb 2024: Cambridge Immunology Network - MRC Laboratory of Molecular Biology https://www.immunology.cam.ac.uk/departments/mrc-lmb en Conor O'Donovan https://www.immunology.cam.ac.uk/staff/conor-odonovan <div class="field field-name-field-sd-consultancy

23 Feb 2024: Br J Cancer. 2013 Apr 2;108(6):1340-7. doi: 10.1038/bjc.2013.66./pnpa href="http://www.ncbi.nlm.nih.gov/pubmed/23341460"p53 and translation attenuation regulate

23 Feb 2024: Cambridge Immunology Network - Molecular and structural immunology https://www.immunology.cam.ac.uk/Networkdirectory/research-themes/molecular-structural-immunology Molecular and structural techniques are used to address a wide range of

23 Feb 2024: Tweddle DA.<br /> p53 is a Direct Transcriptional Target of MYCN in Neuroblastoma.<br /> Cancer Res.

23 Feb 2024: and McKenzie, A.N.J. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q^– syndrome.