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https://www2.mrc-lmb.cam.ac.uk/groups/fersht/26 Jan 2021: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... Tumour Suppressor p53. Structural Biology and Drug Discovery. Alan Fersht. MRC Laboratory of Molecular Biology. -
Generic nature of the condensed states of proteins
www-vendruscolo.ch.cam.ac.uk/Fuxreiter-2021-NCB.pdf7 Sep 2021: L., Stott, K., Watson, M. & Thomas, J. O. HMGB1-facilitated p53 DNA binding occurs via HMG–Box/p53 transactivation domain interaction, regulated by the acidic tail. ... p53 amyloid formation leading to its loss of function: implications in cancer -
How DNA damage induces appetite suppression and weight loss - MRC…
https://www2.mrc-lmb.cam.ac.uk/how-dna-damage-induces-appetite-suppression-and-weight-loss/24 Nov 2021: Inset, model of the molecular mechanism by which ADH5 and CSB cooperate to protect cells from damage, which is sensed by the stalled transcription machinery and can trigger p53 dependent activation -
RNA structure in health and disease - investigation of ...
https://www.physbiol.cam.ac.uk/files/8_-_cpb_undergraduate_summer_studenthip_russell_hamilton.pdf28 May 2021: Motifs with in Gtl2 lncRNA have been shown to be key to the stimulation of the p53 pathway (Uroda et al, 2019, Mol. -
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https://www.mrc-mbu.cam.ac.uk/files/buddy-2021q4-20211001-dist_0.xlsx4 Oct 2021: Legend. Buddy dataset of mitochondrial disease and dysfunction (20211001). Columns:. Ensembl ID: Ensembl gene identifier. Symbol: Gene symbol. Name: Gene name. IMPI-2021Q4pre: Classification of mitochondrial proteome from IMPI (http://www.mrc-mbu.cam -
A Qualitative Model of Older Adults' Contextual Decision-Making…
https://www.cl.cam.ac.uk/~rja14/shb20/FrikEtAl_WEIS2020_final.pdf20 Jul 2021: A Qualitative Model of Older Adults’ ContextualDecision-Making About Information Sharing. ALISA FRIK, International Computer Science Institute; University of California, BerkeleyJULIA BERND, International Computer Science Institute; University of -
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https://www.mrc-mbu.cam.ac.uk/files/impi-2020-q3pre.xlsx1 Oct 2021: Table Legend. Supplementary Data: IMPI. Data sets for protein-encoding human genes in Ensembl. Annotation includes: Evidence of subcellular localisation; Manual curation of literature; IMPI localisation score for likelihood of a mitochondrial -
Legend
https://www.mrc-mbu.cam.ac.uk/files/impi-2021-q4pre-20211001-dist_0.xlsx4 Oct 2021: Legend. Integrated Mitochondrial Protein Index (IMPI) [2021Q4pre-20211001]. Sheets:. 1) Table Legend. 2) IMPI All Human Genes (Ensembl): All human genes with annotation, curation and IMPI localisation score. Ensembl Gene ID: Gene identifier for
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