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Researchers "drug the undruggable" - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/researchers-drug-undruggable/20 Oct 2017: can bind to and deactivate an enzyme that controls the stability of the p53 tumour suppressor protein. ... This deactivation allows p53 to be turned on, putting the brakes on cancer growth. -
Dynamic structure of human DNA repair enzyme, ATM, revealed - MRC…
https://www2.mrc-lmb.cam.ac.uk/dynamic-structure-human-dna-repair-enzyme-atm-revealed/11 May 2017: the damage, including arresting the cell cycle by phosphorylating the checkpoint kinase CHK2 and, under some conditions, inducing apoptosis by phosphorylating p53 and preventing its degradation. ... Using p53 produced by Tomas Kouba in Alan Fersht’s -
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www-vendruscolo.ch.cam.ac.uk/hultqvist2017elife.pdf17 Sep 2017: TAD) of human p53 (p53TAD) and the globular pointed (PNT) domain from human ETS-2. -
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www-vendruscolo.ch.cam.ac.uk/kitevski-leblanc2017elife.pdf17 Sep 2017: proteins, 53BP1: p53 binding protein 1, Ub: ubiquitin, P: phosphate group, Me: methyl group.
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