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Scheres lab
https://www2.mrc-lmb.cam.ac.uk/groups/scheres/publications.html23 Jul 2024: Valle (2011) "Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA". -
Featured Articles Archives - Page 14 of 32 - School of Clinical…
https://www.medschl.cam.ac.uk/category/feature/page/14/23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism -
Graduate Poster Display | Pembroke
https://www.pem.cam.ac.uk/college/news/graduate-poster-display26 Jul 2024: Chiba Ene (PhD Medical Sciences) - Histone demethylase Jumonji D3 (JMJD3) as a Tumor Suppressor by Regulating p53 Activity through Lysine Demethylation. -
Dr Mattia Frontini | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/directory/mfrontini23 Feb 2024: Interaction between the Cockayne syndrome B and p53 proteins: implications for aging. ... CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination. -
Professor Brian Huntly | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/people/pi/huntly23 Feb 2024: In association with an alteration of the DNA damage response mediated through suboptimal Crebbp acetylation of p53, DNA double strand breaks accumulate and accompanied by a relative decrease in apoptosis, lead -
Research - Professor Marciniak's Group
https://www.med.cam.ac.uk/marciniak/research/23 Feb 2024: Marciniak. 2013. p53 and Translation Attenuation Regulate Distinct Cell Cycle Checkpoints during Endoplasmic Reticulum (ER) Stress. -
spongistatin 1
https://www-jmg.ch.cam.ac.uk/data/molecules/polyketides/spongistatin.html18 Jul 2024: s66;P5;P57;P53;P52;P50;P24;N8;s3;s76;d76;N15;s79;N17;N29;N24;s82;s84;d84;/rC:-.3572,3.7125,0;-.3572,2.8875,0;1.0717,2. -
Publications | Knowles Lab
https://www-knowles.ch.cam.ac.uk/publications26 Jul 2024: Journal: Scientific Reports 12 (1). ------------------------------. Characterization of full-length p53 aggregates and their kinetics of formation. -
Ingo Ringshausen | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/directory/ingo-ringshausen23 Feb 2024: Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. ... Cancer Cell, 2006. 10(6): p. 501-14 PMID:17157790. Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI The pathological response to DNA damage does not -
Protein engineering pioneer awarded Royal Society Copley Medal |…
https://www.ch.cam.ac.uk/news/protein-engineering-pioneer-awarded-royal-society-copley-medal26 Jul 2024: His work is now focussed on how mutation affects proteins in the cell cycle, particularly the tumour suppressor p53 – the so-called “Guardian of the Genome” – in order to design novel -
Aims and Objectives | Department of Biochemistry
https://www.bioc.cam.ac.uk/teaching/fourth-year/biochemistry/guidance27 Jul 2024: Cancer studies. Including cell cycle and cancer, use of mouse models, genome-wide sequencing and genome-wide disease association, leukaemia, p53, cancer therapeutics, recombinant antibody generation, commercial drug design and development, -
Publications - Kaser Group
https://www.med.cam.ac.uk/kaser/publications/23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Kaser Group. Publications. Reviews & Editorials. 2024 University of Cambridge. -
https://www.pdn.cam.ac.uk/taxonomy/term/59/feed
https://www.pdn.cam.ac.uk/taxonomy/term/59/feed27 Jul 2024: Department of Physiology, Development and Neuroscience - Academics https://www.pdn.cam.ac.uk/directory/faculty en Sumru Bayin https://www.pdn.cam.ac.uk/staff/bayin <div class="field field-name-field-sd-consultancy field-type-list-boolean -
Robert Lamplough Mann, Lieutenant, 7th Dragoon Guards | Jesus College …
https://www.jesus.cam.ac.uk/robert-lamplough-mann-lieutenant-7th-dragoon-guards26 Jul 2024: Mann was originally thought to have been wounded on 29 December 1914 and was recorded as a prisoner of war on 25 March 1915 (Jesus College Society Annual Report, 1916, p53).
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Professor Sir David Klenerman FMedSci FRS | Yusuf Hamied Department…
https://www.ch.cam.ac.uk/person/dk1001226 Jul 2024: Imaging aggregates of P53 and determining the role of these aggregates in the development and spreading of cancer. -
Jussi Taipale | Department of Biochemistry
https://www.bioc.cam.ac.uk/research/taipale27 Jul 2024: CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response. Nat. Med., 24(7):927-930. -
Katy Brown, PhD | Bioinformatics Training
https://bioinfotraining.bio.cam.ac.uk/staff/katy-brown-phd27 Jul 2024: Contributors: Ingrida Olendraite; Katherine Brown; Andrew E. Firth. A novel map of human p53 response elements uncovers evidence of selection pressures and variants similar to Li-Fraumeni Syndrome mutations. ... Germline and Somatic Genetic Variants in -
Publications | Wales Group
https://www.ch.cam.ac.uk/group/wales/publications?page=1426 Jul 2024: J Chem Phys. (2009). 130,. 194508. (doi: 10.1063/1.3131690). Computer Simulations of Peptides from the p53 DNA Binding Domain. -
School News Archives - Page 12 of 29 - School of Clinical Medicine
https://www.medschl.cam.ac.uk/category/schoolnews/page/12/23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism -
Publications - Dr Rana's Group
https://www.med.cam.ac.uk/rana/publications/23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Dr Rana's Group. Publications. 2024 University of Cambridge. -
Dr Maria Christophorou | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/people/affiliates/christophorou23 Feb 2024: She did her PhD with Gerard Evan at UCSF, where she was able to dissect the relative contributions of different p53 activating signals towards tumour suppression using mouse models of conditional ... p53 perturbation. -
Dr Matthew Cheetham | Yusuf Hamied Department of Chemistry
https://www.ch.cam.ac.uk/person/mrc7926 Jul 2024: Lee. (2023). (doi: 10.1101/2023.02.07.527479). Characterization of full-length p53 aggregates and their kinetics of formation. -
Svetlana Khoronenkova | Department of Biochemistry
https://www.bioc.cam.ac.uk/research/khoronenkova27 Jul 2024: ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. -
Publications | Clarke Group
https://www.ch.cam.ac.uk/group/sclarke/publications?page=226 Jul 2024: 1474. (doi: 10.1016/j.bpj.2020.09.007). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation. -
Research News Archives - Page 12 of 29 - School of Clinical Medicine
https://www.medschl.cam.ac.uk/category/schoolnews/research-news/page/12/23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism -
Publications | Centre for Atmospheric Science
https://www.ch.cam.ac.uk/group/atm/publications?page=1426 Jul 2024: Weather. (2020). 75,. 353. (doi: 10.1002/wea.3795). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation. -
https://www.pdn.cam.ac.uk/taxonomy/term/58/feed
https://www.pdn.cam.ac.uk/taxonomy/term/58/feed27 Jul 2024: b>. Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis. -
Dr Florian Merkle | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/people/affiliates/merkle23 Feb 2024: For example, we recently showed that hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation -
Publications
https://www-neurosciences.medschl.cam.ac.uk/horvathlab/publications/23 Feb 2024: RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels. -
Florian T. Merkle - Institute of Metabolic Science-Metabolic Research …
https://www.mrl.ims.cam.ac.uk/research/principal-investigators/florian-t-merkle/23 Feb 2024: For example, hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation from transplanted cells (Merkle ... Human pluripotent stem cells -
Dr Suzanne Dawn Turner | Cambridge Immunology Network
https://www.immunology.cam.ac.uk/Networkdirectory/sdturner23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... Merkel, O., Morrigl, R.,Turner, S.D. and Kenner, L. (2017) When the -
Professor Brian Huntly | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/directory/brian-huntly23 Feb 2024: In association with an alteration of the DNA damage response mediated through suboptimal Crebbp acetylation of p53, DNA double strand breaks accumulate and accompanied by a relative decrease in apoptosis, lead -
Publications - Professor Marciniak's Group
https://www.med.cam.ac.uk/marciniak/publications/23 Feb 2024: p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress. -
Autophagy-mediated apoptosis eliminates chromosomally abnormal cells…
https://www.trophoblast.cam.ac.uk/news/autophagy-mediated-apoptosis-eliminates-chromosomally-abnormal-cells-from-the-mouse-epiblast26 Jul 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and -
Queens' Library General Collection
https://www.queens.cam.ac.uk/files/downloads/general_collection.html3 Jan 2024: p53 : the gene that cracked the cancer code. -
https://www.med.cam.ac.uk/rana/wp-json/wp/v2/pages/26
https://www.med.cam.ac.uk/rana/wp-json/wp/v2/pages/2623 Feb 2024: {"id":26,"date":"2011-03-01T14:00:13","date_gmt":"2011-03-01T14:00:13","guid":{"rendered":"http://www.med.cam.ac.uk/infectious-diseases/?page_id=26"},"modified":"2015-01-12T14:44:42","modified_gmt":"2015-01-12T14:44:42","slug":"publications","status" -
Protein and Nucleic Acid Chemistry - MRC Laboratory of Molecular…
https://www2.mrc-lmb.cam.ac.uk/research/protein-and-nucleic-acid-chemistry/20 May 2024: Alan Fersht - Tumour suppressor p53 structure and drug discovery.
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CDD-MRC Conference on “Genes vs Environment in Cancer” | MRC…
https://www.mrc-tox.cam.ac.uk/news/cdd-mrc-conference-genes-vs-environment-cancer27 Jul 2024: p53 in the response to environmental stressors. -
Professor Alan Warren | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/people/affiliates/warren23 Feb 2024: consequence of p53 stabilization in response to ribosomal stress. -
Part II Exam Questions Reports 2018/19 (incomplete) Paper 1 ...
https://www.ch.cam.ac.uk/teaching/files/Examiners%20Reports/Part%20II_ExamReports%20_2018-19.pdf9 Jul 2024: The best students got this correct. Many students also thought the protein, p53 had disulphide bridges. ... p53 was covered in the lectures as a nuclear protein that bound DNA so they should have been aware it is in a reducing environment. -
Cytosponge biomarker panel used to prioritise endoscopic…
https://www.oncology.cam.ac.uk/news/cytosponge-biomarker-panel-used-prioritise-endoscopic-barretts-oesophagus-surveillance23 Feb 2024: Published in The Lancet Oncology, researchers evaluated the role of the Cytosponge atypia, p53 overexpression, and clinical risk factors (age, sex, and segment length) to prioritise patients for endoscopy. -
https://www.med.cam.ac.uk/bennett/wp-json/wp/v2/pages/26
https://www.med.cam.ac.uk/bennett/wp-json/wp/v2/pages/2623 Feb 2024: {"id":26,"date":"2011-03-01T14:00:13","date_gmt":"2011-03-01T14:00:13","guid":{"rendered":"http://www.med.cam.ac.uk/infectious-diseases/?page_id=26"},"modified":"2015-02-06T11:14:05","modified_gmt":"2015-02-06T11:14:05","slug":"publications","status" -
Greta Skrupskelyte | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/directory/great-skrupskelyte23 Feb 2024: 2018) Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations. -
Dr Ingo Ringshausen - Department of Haematology
https://www.haem.cam.ac.uk/staff/senior-staff/dr-ingo-ringshausen/23 Feb 2024: Swigart, and G.I. Evan. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. ... Finch, L.B. Swigart, and G.I. Evan. Thepathological response to DNA damage does not contribute to p53-mediated tumour suppression. -
Jason William Chin Page 1 of 18 MRC Laboratory ...
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-content/uploads/2024/01/Chin-cv-26012024.pdf29 Jan 2024: Chin, W. Fischle, S.M. Gasser. EMBO J. 2011. 30: 2610-2621. (53) Acetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration. -
https://www.phar.cam.ac.uk/taxonomy/term/5/feed
https://www.phar.cam.ac.uk/taxonomy/term/5/feed27 Jul 2024: Department of Pharmacology - Academic Staff https://www.phar.cam.ac.uk/directory/academicstaff An A-Z directory of all Department members can be found here. The Department provides contact details for all members of the Department. Please follow the -
Computational modelling of cancer and aging | Department of Genetics
https://www.gen.cam.ac.uk/research/research-groups/computational-modelling-cancer-and-aging27 Jul 2024: Simulations reveal that different responses to cell crowding determine the expansion of p53 and Notch mutant clones in squamous epithelia. -
Professor Margaret Ashcroft | Cambridge Immunology Network
https://www.immunology.cam.ac.uk/Networkdirectory/margaretashcroft23 Feb 2024: Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1. ... Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell -
Dr Pentao Liu | Cambridge Immunology Network
https://www.immunology.cam.ac.uk/Networkdirectory/pl2%40sanger.ac.uk23 Feb 2024: By contrast, overactivity of Bcl11a is known to cause lymphomas. One member of the Bcl11a network is p53, known to be important in controlling cell division and, when mutated, important in ... If p53 also is inactivated in mice that lack Bcl11a, some -
George Eric Fairbairn, 2nd Lieutenant, 10th Durham Light Infantry |…
https://www.jesus.cam.ac.uk/george-eric-fairbairn-2nd-lieutenant-10th-durham-light-infantry26 Jul 2024: He hates collars, takes no milk in his tea through fear of dead flies, and is a confirmed Peripatetic after bump-suppers” (Chanticlere, Lent Term 1909, p53 and p37 respectively).
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