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Dr Maria Christophorou | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/people/affiliates/christophorou23 Feb 2024: She did her PhD with Gerard Evan at UCSF, where she was able to dissect the relative contributions of different p53 activating signals towards tumour suppression using mouse models of conditional ... p53 perturbation. -
Dr Matthew Cheetham | Yusuf Hamied Department of Chemistry
https://www.ch.cam.ac.uk/person/mrc7926 Jul 2024: Lee. (2023). (doi: 10.1101/2023.02.07.527479). Characterization of full-length p53 aggregates and their kinetics of formation. -
Svetlana Khoronenkova | Department of Biochemistry
https://www.bioc.cam.ac.uk/research/khoronenkova27 Jul 2024: ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. -
Publications | Clarke Group
https://www.ch.cam.ac.uk/group/sclarke/publications?page=226 Jul 2024: 1474. (doi: 10.1016/j.bpj.2020.09.007). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation. -
Research News Archives - Page 12 of 29 - School of Clinical Medicine
https://www.medschl.cam.ac.uk/category/schoolnews/research-news/page/12/23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism -
Publications | Centre for Atmospheric Science
https://www.ch.cam.ac.uk/group/atm/publications?page=1426 Jul 2024: Weather. (2020). 75,. 353. (doi: 10.1002/wea.3795). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation. -
https://www.pdn.cam.ac.uk/taxonomy/term/58/feed
https://www.pdn.cam.ac.uk/taxonomy/term/58/feed27 Jul 2024: b>. Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis. -
Dr Florian Merkle | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/people/affiliates/merkle23 Feb 2024: For example, we recently showed that hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation -
Publications
https://www-neurosciences.medschl.cam.ac.uk/horvathlab/publications/23 Feb 2024: RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels. -
Florian T. Merkle - Institute of Metabolic Science-Metabolic Research …
https://www.mrl.ims.cam.ac.uk/research/principal-investigators/florian-t-merkle/23 Feb 2024: For example, hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation from transplanted cells (Merkle ... Human pluripotent stem cells -
Dr Suzanne Dawn Turner | Cambridge Immunology Network
https://www.immunology.cam.ac.uk/Networkdirectory/sdturner23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... Merkel, O., Morrigl, R.,Turner, S.D. and Kenner, L. (2017) When the -
Professor Brian Huntly | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/directory/brian-huntly23 Feb 2024: In association with an alteration of the DNA damage response mediated through suboptimal Crebbp acetylation of p53, DNA double strand breaks accumulate and accompanied by a relative decrease in apoptosis, lead -
Publications - Professor Marciniak's Group
https://www.med.cam.ac.uk/marciniak/publications/23 Feb 2024: p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress. -
Autophagy-mediated apoptosis eliminates chromosomally abnormal cells…
https://www.trophoblast.cam.ac.uk/news/autophagy-mediated-apoptosis-eliminates-chromosomally-abnormal-cells-from-the-mouse-epiblast26 Jul 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and -
Queens' Library General Collection
https://www.queens.cam.ac.uk/files/downloads/general_collection.html3 Jan 2024: p53 : the gene that cracked the cancer code. -
https://www.med.cam.ac.uk/rana/wp-json/wp/v2/pages/26
https://www.med.cam.ac.uk/rana/wp-json/wp/v2/pages/2623 Feb 2024: {"id":26,"date":"2011-03-01T14:00:13","date_gmt":"2011-03-01T14:00:13","guid":{"rendered":"http://www.med.cam.ac.uk/infectious-diseases/?page_id=26"},"modified":"2015-01-12T14:44:42","modified_gmt":"2015-01-12T14:44:42","slug":"publications","status" -
Protein and Nucleic Acid Chemistry - MRC Laboratory of Molecular…
https://www2.mrc-lmb.cam.ac.uk/research/protein-and-nucleic-acid-chemistry/20 May 2024: Alan Fersht - Tumour suppressor p53 structure and drug discovery.
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CDD-MRC Conference on “Genes vs Environment in Cancer” | MRC…
https://www.mrc-tox.cam.ac.uk/news/cdd-mrc-conference-genes-vs-environment-cancer27 Jul 2024: p53 in the response to environmental stressors. -
Professor Alan Warren | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/people/affiliates/warren23 Feb 2024: consequence of p53 stabilization in response to ribosomal stress. -
Part II Exam Questions Reports 2018/19 (incomplete) Paper 1 ...
https://www.ch.cam.ac.uk/teaching/files/Examiners%20Reports/Part%20II_ExamReports%20_2018-19.pdf9 Jul 2024: The best students got this correct. Many students also thought the protein, p53 had disulphide bridges. ... p53 was covered in the lectures as a nuclear protein that bound DNA so they should have been aware it is in a reducing environment.
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