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Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of …
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/CircGen_2019.pdf1 Dec 2019: Circ Genom Precis Med. 2019;12:e002507. DOI: 10.1161/CIRCGEN.119.002507 September 2019 397. BACKGROUND: Pediatric cardiomyopathies are a clinically and genetically heterogeneous group of heart muscle disorders associated with high morbidity and -
Membrane fusion is the process whereby two separate lipid ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/MartensMcMahon2008.pdf16 May 2008: derived from a retrovirus. Syncytins function in cell–cell fusion during trophoblast formation. Immunoglobulin (Ig)-like -
doi:10.1016/j.cell.2006.01.047
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16615893.pdf18 Apr 2006: levels, is that overexpression of exogenous Tsg101 se-. questers endogenous Tsg101 binding partners (Vps28. ... Tal, a Tsg101-spe-. cific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus. Results that match 1 of 2 words
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2022 John Kendrew Lecture to be given by Alice Ting - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/2022-john-kendrew-lecture-to-be-given-by-alice-ting/5 May 2022: Enzyme-catalyzed proximity labeling (PL) has emerged as a powerful and generalizable method to map the locations and interactions of endogenous proteins in the context of living cells, applicable to even -
A fundamental protection mechanism against formalin in mammals is…
https://www2.mrc-lmb.cam.ac.uk/a-fundamental-protection-mechanism-against-formalin-in-mammals-is-revealed/25 Sep 2015: This was because endogenous formaldehyde destroyed the blood stem cells residing in the bone marrow. ... In these patients reducing or counteracting endogenous formaldehyde production may be of therapeutic value. -
Books - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/archive/books/21 Jul 2023: Paperback, 135pp. Includes: Technology Transfer in Britain: The case of Monoclonal Antibodies, Self and Non-self: A history of Autoimmunity, Endogenous Opiates, The Committee on Safety of Drugs. -
Genetic code expansion in model organisms
https://www2.mrc-lmb.cam.ac.uk/ccsb/research/genetic-code-expansion-in-animals/The pyrrolysyl-tRNA synthetase tRNA. CUA. pair is orthogonal with respect to the endogenous synthetases and tRNAs in E. -
Photochemical genetics
https://www2.mrc-lmb.cam.ac.uk/ccsb/research/photochemical-genetics/Comparison of the kinetics of ERK2–GFP nuclear accumulation following MEK photoactivation or endogenous receptor stimulation provided some interesting insights. -
Protein labeling and imaging
https://www2.mrc-lmb.cam.ac.uk/ccsb/research/protein-labeling/Note that despite endogenous amber codons we see minimal background labeling of non-target proteins, either on the cell surface or intracellularly. -
Reprogramming translation
https://www2.mrc-lmb.cam.ac.uk/ccsb/research/reprogramming-translation/In the first step we created an orthogonal ribosome that is selectively directed to a new orthogonal message that is not read by endogenous ribosomes. ... We first selected, on 5FU, for sequences upstream of the cat-upp fusion that do not allow the gene
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