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Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of …
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/CircGen_2019.pdf1 Dec 2019: Circ Genom Precis Med. 2019;12:e002507. DOI: 10.1161/CIRCGEN.119.002507 September 2019 397. BACKGROUND: Pediatric cardiomyopathies are a clinically and genetically heterogeneous group of heart muscle disorders associated with high morbidity and -
Membrane fusion is the process whereby two separate lipid ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/MartensMcMahon2008.pdf16 May 2008: derived from a retrovirus. Syncytins function in cell–cell fusion during trophoblast formation. Immunoglobulin (Ig)-like -
doi:10.1016/j.cell.2006.01.047
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16615893.pdf18 Apr 2006: levels, is that overexpression of exogenous Tsg101 se-. questers endogenous Tsg101 binding partners (Vps28. ... Tal, a Tsg101-spe-. cific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus. Results that match 1 of 2 words
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Link between shape shifting protein and HIV resistance - MRC…
https://www2.mrc-lmb.cam.ac.uk/link-between-shape-shifting-protein-and-hiv-resistance/12 Mar 2012: The research team included collaborators from the MRC Centre for Medical Molecular Virology and the Retrovirus Research Laboratory, MRC University of Glasgow Centre for Virus Research. -
Protein labeling and imaging
https://www2.mrc-lmb.cam.ac.uk/ccsb/research/protein-labeling/Note that despite endogenous amber codons we see minimal background labeling of non-target proteins, either on the cell surface or intracellularly. -
Effects of Epsin R overexpression
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/epsinR/epsinrD422R.html17 Oct 2007: EpsinR D342R D422R overexpression in COS cells. Mutation of these two residues affects the interaction of EpsinR with clathrin. The phenotype is less severe than the lipid binding mutant (D34G R67L). pointing again to the importance of the ENTH -
Discovering the origins of biological timekeeping - MRC Laboratory of …
https://www2.mrc-lmb.cam.ac.uk/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww2.mrc-lmb.cam.ac.uk%2Fdiscovering-the-origins-of-biological-timekeeping%2F&format=xmlexistence of an endogenous daily clock in humans is well known: it is what drives the 24-hour sleep/wake rhythm to match the daily cycle of night and. -
ppat.1000479 1..19
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/60_Ashok_A_PLoS_Path_2009.pdf20 Jun 2009: completely unrelated human cell line that expresses very low (but. detectable) levels of endogenous PrP. ... presence or absence of endogenous PrP in co-expression. experiments (e.g., as in Fig. -
doi:10.1016/j.str.2008.06.010
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/18786397.pdf3 Sep 2008: Similar endogenous fila-. ments (presumably of ESCRT-III components) were observed. when an ATP-locked mutant of Vps4 (VPS4BE235Q) was overex-. -
2022 John Kendrew Lecture to be given by Alice Ting - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/2022-john-kendrew-lecture-to-be-given-by-alice-ting/5 May 2022: Enzyme-catalyzed proximity labeling (PL) has emerged as a powerful and generalizable method to map the locations and interactions of endogenous proteins in the context of living cells, applicable to even
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