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Robyn Macrae | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/directory/robyn-macrae23 Feb 2024: Title: The apelin signalling system is composed of the G-protein coupled apelin receptor and its two endogenous peptide ligands, apelin and Elabela/Toddler (ELA). ... Structure and pharmacology of the apelin receptor with a recommendation that -
Dr Janet Maguire | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/directory/jmaguire23 Feb 2024: Pyr. 1. ]apelin-13. (1-12). is a biologically active ACE2 metabolite of the endogenous cardiovascular peptide [Pyr. ... Elabela/Toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration -
Poster Abstracts | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/poster-abstracts23 Feb 2024: Background: The apelin receptor, a class A GPCR, binds two endogenous peptide ligands, apelin and ELA, to induce potent vasodilatation and increase cardiac output. ... Considering these limitations, we are developing a novel method for stimulating -
https://www.cardiovascular.cam.ac.uk/taxonomy/term/11/feed
https://www.cardiovascular.cam.ac.uk/taxonomy/term/11/feed23 Feb 2024: Structure and pharmacology of the apelin receptor with a recommendation that Elabela/Toddler is a second endogenous peptide ligand. ... and its two endogenous peptide ligands, apelin and Elabela/Toddler (ELA). -
Prof Anthony Davenport | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/directory/adavenport23 Feb 2024: In first in human, proof of principle studies, MM07 was a more efficacious dilator in human forearm and hand vein via the G-protein mediated pathway than the endogenous peptides. ... and Maguire, J,J. (2017) [Pyr. 1. ]Apelin-13. (1-12). is a biologically -
BHF Oxbridge CRM Pump-Priming Funding | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/research/oxbridgecrm/bhf-centre-of-regenerative-medicine-funding23 Feb 2024: Bristol. Development of novel zebrafish models to analyse endogenous extracellular vesicle trafficking during the cardiac injury response and subsequent regeneration.. -
Dr Wei Li | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/directory/wli23 Feb 2024: We also show that loss of endogenous BMP9 leads to lung vascular leak in vivo, and have developed BMP9 variants that maintain endothelial protective function but lack the bone-forming activity. -
https://www.cardiovascular.cam.ac.uk/taxonomy/term/30/feed
https://www.cardiovascular.cam.ac.uk/taxonomy/term/30/feed23 Feb 2024: of metabolism in multiple species by endogenous enzymes.</a> Kirchmair J, Williamson MJ, Afzal AM, Tyzack JD, Choy AP, Howlett A, Rydberg P, <b>Glen RC</b>.<span class="jrnl" -
https://www.cardiovascular.cam.ac.uk/taxonomy/term/7/feed
https://www.cardiovascular.cam.ac.uk/taxonomy/term/7/feed23 Feb 2024: Structure and pharmacology of the apelin receptor with a recommendation that Elabela/Toddler is a second endogenous peptide ligand. -
Dr Joseph Cheriyan | Cambridge Cardiovascular
https://www.cardiovascular.cam.ac.uk/directory/jcheriyan23 Feb 2024: Pyr1]Apelin-13(1-12) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr1]Apelin-13.
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