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23 Feb 2024: Title: The apelin signalling system is composed of the G-protein coupled apelin receptor and its two endogenous peptide ligands, apelin and Elabela/Toddler (ELA). ... Structure and pharmacology of the apelin receptor with a recommendation that

23 Feb 2024: To harness the capacity of endogenous stem cell and progenitor cells for repair and regeneration.

23 Feb 2024: of metabolism in multiple species by endogenous enzymes.</a> Kirchmair J, Williamson MJ, Afzal AM, Tyzack JD, Choy AP, Howlett A, Rydberg P, <b>Glen RC</b>.<span class="jrnl"

23 Feb 2024: Background: The apelin receptor, a class A GPCR, binds two endogenous peptide ligands, apelin and ELA, to induce potent vasodilatation and increase cardiac output. ... Considering these limitations, we are developing a novel method for stimulating

23 Feb 2024: Pyr. 1. ]apelin-13. (1-12). is a biologically active ACE2 metabolite of the endogenous cardiovascular peptide [Pyr. ... Elabela/Toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration

23 Feb 2024: Bristol. Development of novel zebrafish models to analyse endogenous extracellular vesicle trafficking during the cardiac injury response and subsequent regeneration..

23 Feb 2024: In first in human, proof of principle studies, MM07 was a more efficacious dilator in human forearm and hand vein via the G-protein mediated pathway than the endogenous peptides. ... and Maguire, J,J. (2017) [Pyr. 1. ]Apelin-13. (1-12). is a biologically

23 Feb 2024: Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.

23 Feb 2024: Recently, our lab defined the direct overall contribution of endogenous antibodies to atherosclerosis in a fully immunocompetent model.

23 Feb 2024: We also show that loss of endogenous BMP9 leads to lung vascular leak in vivo, and have developed BMP9 variants that maintain endothelial protective function but lack the bone-forming activity.

23 Feb 2024: Endogenous signalling pathways and caged-IP. 3. evoke Ca. 2+. puffs at the same abundant immobile intracellular sites.

23 Feb 2024: FAst MEtabolizer (FAME): A rapid and accurate predictor of sites of metabolism in multiple species by endogenous enzymes.

23 Feb 2024: Pyr1]Apelin-13(1-12) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr1]Apelin-13.

23 Feb 2024: of metabolism in multiple species by endogenous enzymes.</a> Kirchmair J, Williamson MJ, Afzal AM, Tyzack JD, Choy AP, Howlett A, Rydberg P, <b>Glen RC</b>.<span class="jrnl"

23 Feb 2024: Structure and pharmacology of the apelin receptor with a recommendation that Elabela/Toddler is a second endogenous peptide ligand.

23 Feb 2024: Structure and pharmacology of the apelin receptor with a recommendation that Elabela/Toddler is a second endogenous peptide ligand. ... and its two endogenous peptide ligands, apelin and Elabela/Toddler (ELA).

12:30-13:30 Welcome lunch. 13:30-13:35 Welcome Symposium 1 - Endogenous Cardiac Repair and Regeneration.

23 Feb 2024: Structure and pharmacology of the apelin receptor with a recommendation that Elabela/Toddler is a second endogenous peptide ligand. ... and its two endogenous peptide ligands, apelin and Elabela/Toddler (ELA).

23 Feb 2024: Cambridge Cardiovascular - Department of Pharmacology https://www.cardiovascular.cam.ac.uk/institutions/dir-pharmacology en Dr Lay Ping Ong https://www.cardiovascular.cam.ac.uk/staff/dr-lay-ping-ong <div class="field field-name-field-sd-consultancy

23 Feb 2024: Cambridge Cardiovascular - Department of Biochemistry https://www.cardiovascular.cam.ac.uk/institutions/dir-biochemistry en Dr Aishwarya Jacob https://www.cardiovascular.cam.ac.uk/staff/dr-aishwarya-jacob <div class="field field-name-body

23 Feb 2024: a href="https://www.ncbi.nlm.nih.gov/pubmed/28293165" target="_self">[Pyr1]Apelin-13(1-12) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide