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Scientists discover genetic disease which causes recurrent…
https://www.cam.ac.uk/research/news/scientists-discover-genetic-disease-which-causes-recurrent-respiratory-infections18 Oct 2013: We called this newly identified disease Activated PI3K- δ Syndrome (APDS) after the enzyme in the immune system that is affected by the genetic mutation.”. ... Although the prevalence of the disease is not yet known, the scientists believe that it is -
CID Annual Symposium 2022 Programme: Flash Talks | Cambridge…
https://www.infectiousdisease.cam.ac.uk/cid-annual-symposium-2022-programme-flash-talks10 May 2024: Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis. Noémie Lefrancq, Department of Genetics. ... These novel insights into Bp dynamics and its interactions with vaccine-induced immunity are highly relevant to vaccination -
https://www.immunology.cam.ac.uk/taxonomy/term/64/feed
https://www.immunology.cam.ac.uk/taxonomy/term/64/feed23 Feb 2024: Vaccine 2010; 28: 6915-22.</p> <p>Baxendale HE, Keating SM, Johnson M, Southern J, Miller E, Goldblatt D. ... class="field-label">Research interests: </div><div class="field-items"><div class="field-item even"><p>B cell lineage and repertoire -
https://www.path.cam.ac.uk/taxonomy/term/15/feed
https://www.path.cam.ac.uk/taxonomy/term/15/feed10 May 2024: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies. Nature 593, 136–141 (2021).</p> <p>• Kemp, S. ... Diffuse White Matter Signal Abnormalities on Magnetic Resonance Imaging Are Associated With Human Immunodeficiency Virus Type 1 -
https://www.anthroencyclopedia.com/taxonomy/term/82/feed
https://www.anthroencyclopedia.com/taxonomy/term/82/feed10 May 2024: Open Encyclopedia of Anthropology - Environment https://www.anthroencyclopedia.com/entry-tags/environment en Infrastructure https://www.anthroencyclopedia.com/entry/infrastructure <div class="image"><img typeof="foaf:Image" -
https://www.anthroencyclopedia.com/taxonomy/term/221/feed
https://www.anthroencyclopedia.com/taxonomy/term/221/feed10 May 2024: Open Encyclopedia of Anthropology - Science & Technology https://www.anthroencyclopedia.com/entry-tags/science-technology en Race and racism https://www.anthroencyclopedia.com/entry/race-and-racism <div class="image"><img typeof="foaf:Image" -
https://www.infectiousdisease.cam.ac.uk/taxonomy/term/46/feed
https://www.infectiousdisease.cam.ac.uk/taxonomy/term/46/feed10 May 2024: Timing of initiation of antiretroviral therapy in human immunodeficiency virus (HIV)-associated tuberculous meningitis. -
https://www.anthroencyclopedia.com/taxonomy/term/172/feed
https://www.anthroencyclopedia.com/taxonomy/term/172/feed10 May 2024: Open Encyclopedia of Anthropology - Care https://www.anthroencyclopedia.com/entry-tags/care en Surveillance https://www.anthroencyclopedia.com/entry/surveillance <div class="image"><img typeof="foaf:Image" -
https://www.infectiousdisease.cam.ac.uk/taxonomy/term/89/feed
https://www.infectiousdisease.cam.ac.uk/taxonomy/term/89/feed10 May 2024: Cushing's</p> <p>syndrome and adrenal axis suppression in a patient treated with ritonavir and</p> <p>corticosteroid eye drops. ... span>. Vaccine preventable diseases in returned international</p> <p>travelers: results from the GeoSentinel Surveillance -
https://www.med.cam.ac.uk/nejentsev/wp-json/wp/v2/pages/6
https://www.med.cam.ac.uk/nejentsev/wp-json/wp/v2/pages/623 Feb 2024: {"id":6,"date":"2011-03-01T11:55:15","date_gmt":"2011-03-01T11:55:15","guid":{"rendered":"http://www.med.cam.ac.uk/infectious-diseases/?page_id=6"},"modified":"2015-02-24T14:33:58","modified_gmt":"2015-02-24T14:33:58","slug":"research","status":"publ -
Dr Rachael Bashford-Rogers | Cambridge Immunology Network
https://www.immunology.cam.ac.uk/Networkdirectory/rachaelbf23 Feb 2024: Defects in the ability to mount effective B cell or T cell responses have been implicated in infectious susceptibility, impaired surveillance of cancer and immunodeficiencies, whereas a breakdown of immunological tolerance ... Transmission and evolution -
https://www.path.cam.ac.uk/taxonomy/term/9/feed
https://www.path.cam.ac.uk/taxonomy/term/9/feed10 May 2024: Contrasting effects of linezolid on healthy and dysfunctional human neutrophils: reducing C5a-induced injury. ... Monocytes control second-phase neutrophil emigration in established LPS-induced murine lung injury. -
The Academy of Medical Sciences announces election of new Fellows…
https://www.cam.ac.uk/research/news/the-academy-of-medical-sciences-announces-election-of-new-fellows-202112 May 2021: the process by which new variants likely arise, and also reporting the first data on Pfizer BioNTech vaccine-induced antibody responses against the B.1.1.7 ‘Kent UK’ variant. ... His research investigates the basis for pathological immune activation -
Julia Kenyon
https://www.homerton.cam.ac.uk/people/julia-kenyonShe leads and collaborates in research on HIV, FIV (feline immunodeficiency virus), dengue virus and influenza virus. ... Viruses 3(11) 2192-2213. Kenyon JC, Lever AML (2011) XMRV, Prostate Cancer and Chronic Fatigue Syndrome. -
https://www.infectiousdisease.cam.ac.uk/taxonomy/term/181/feed
https://www.infectiousdisease.cam.ac.uk/taxonomy/term/181/feed10 May 2024: In recent years, he has contributed to the description of a new primary immunodeficiency syndrome caused by activated PI3Kδ mutations (APDS) and his group demonstrated that deletion of PI3Kδ in regulatory -
Professor Willem H Ouwehand - Department of Haematology
https://www.haem.cam.ac.uk/staff/senior-staff/professor-willem-h-ouwehand/23 Feb 2024: Large genome-wide association study identifies three novel risk variants for restless legs syndrome. ... Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature. 2020 Jul;583(7814):90-95. -
https://www.infectiousdisease.cam.ac.uk/taxonomy/term/187/feed
https://www.infectiousdisease.cam.ac.uk/taxonomy/term/187/feed10 May 2024: Epstein-Barr Virus Induced One-Carbon Metabolism Drives B-Cell Transformation. 2019. Cell Metabolism. ... Temporal proteomic analysis of BK polyomavirus infection reveals virus-induced G2 arrest and highly effective evasion of innate immune sensing. -
https://www.infectiousdisease.cam.ac.uk/taxonomy/term/100/feed
https://www.infectiousdisease.cam.ac.uk/taxonomy/term/100/feed10 May 2024: CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages. ... 2009). Multiple redundant stress resistance mechanisms are induced i<i>n Salmonella enterica </i>serovar Typhimurium<i> </i>in response to modulation -
Dr Sara Lear | Cambridge Immunology Network
https://www.immunology.cam.ac.uk/Networkdirectory/sara.lear%40nhs.net23 Feb 2024: The department has an interest in innate immunity, B cell lineage and repertoire development; natural and vaccine induced immunity to streptococcus pneumonia in health and chronic disease. ... Anti-tumour necrosis factor-alpha therapy for severe -
https://www.path.cam.ac.uk/taxonomy/term/7/feed
https://www.path.cam.ac.uk/taxonomy/term/7/feed10 May 2024: 29875319.pdf" target="_blank">[PDF]</a></p> <p><a href="http://www.ncbi.nlm.nih.gov/pubmed/29540581" target="_blank"><b>Bach2 Promotes B Cell Receptor-Induced Proliferation of B Lymphocytes ... ncbi.nlm.nih.gov/pubmed/28530713" target="_blank"><b>BACH2 -
Discovery of the genetic basis of a rare immune disease - MRC…
https://www2.mrc-lmb.cam.ac.uk/discovery-of-the-genetic-basis-of-a-rare-immune-disease/22 Oct 2013: The researchers first examined genetic information from individuals who suffer from immunodeficiency and are predisposed to infections. ... The newly identified disease has been called Activated PI3K-δ Syndrome (APDS) after the enzyme that is affected -
Dr Edward Banham-Hall | Cambridge Immunology Network
https://www.immunology.cam.ac.uk/Networkdirectory/banham-hall23 Feb 2024: During his research he took a leading role in the discovery of a novel cause of Primary Immunodeficiency called Activated PI3kinase Delta Syndrome, or APDS. -
Member: Anna Jane Dreyer - Cambridge Neuroscience
https://neuroscience.cam.ac.uk/member/annajanedreyer1/My current project involves investigating the role of socioeconomic inequalities in the dementia syndromes associated with frontotemporal lobar degeneration and Parkinson's disease. ... Moving on From HAND: Why We Need New Criteria for Cognitive -
Professor Gillian M Griffiths FMedSci, FRS | Cambridge Immunology…
https://www.immunology.cam.ac.uk/Networkdirectory/gg305%40cam.ac.uk23 Feb 2024: Mutations in AP3D1 associated with immunodeficiency and seizures define a new type of Hermansky-Pudlak syndrome. -
https://www.immunology.cam.ac.uk/taxonomy/term/921/feed
https://www.immunology.cam.ac.uk/taxonomy/term/921/feed23 Feb 2024: IRF8 mutations and human dendritic-cell immunodeficiency. N Engl J Med. 2011 Jul 14;365(2):127-38.</p> <p>Bigley V, Haniffa M, Doulatov S, Wang XN, Dickinson R, McGovern ... The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency. -
Publications - Genetic and functional mechanisms of susceptibility to …
tb.med.cam.ac.uk/publications-2/Durandy A. #. (. #. corresponding authors):Occurrence of B-cell lymphomas in patients with activated phosphoinositide 3-kinase δ syndrome. ... A, Doffinger R, Gilmour KC, Henriquez F, Thrasher AJ, Gaspar HB, Nejentsev S:Immunodeficiency and disseminated -
https://www.psychiatry.cam.ac.uk/blog/tag/research-2/feed/
https://www.psychiatry.cam.ac.uk/blog/tag/research-2/feed/16 Feb 2024: An investigation of RF networks and RF mean levels/p pApril Le: Neurophysiological biomarkers of dementia in Down Syndrome/p pSharon Neufeld: Does mental health treatment promote family functioning to mitigate ... of change/p pLucie Aman: Markers of risk -
tb.med.cam.ac.uk/feed/
tb.med.cam.ac.uk/feed/25 Jun 2015: protecting from infection./p pstrongGenetic analyses of patients with Primary Immunodeficiencies/strong/p pPrimary Immunodeficiencies (PIDs) comprise a heterogeneous group of genetic disorders that affect functioning of the immune system and -
Scientists discover genetic disease which causes recurrent…
https://www.med.cam.ac.uk/blog/scientists-discover-genetic-disease-which-causes-recurrent-respiratory-infections/23 Feb 2024: We called this newly identified disease Activated PI3K- δ Syndrome (APDS) after the enzyme in the immune system that is affected by the genetic mutation.”. ... Although the prevalence of the disease is not yet known, the scientists believe that it is -
Cambridge University Reporter Special
https://www.reporter.admin.cam.ac.uk/reporter/2006-07/weekly/6051/13.html28 Jan 2022: The appearance of Human Immunodeficiency Virus (HIV), Severe Acute Respiratory Syndrome (SARS) virus, and new variants of Avian Influenza are well-documented examples. -
Dr Rainer Döffinger | Cambridge Immunology Network
https://www.immunology.cam.ac.uk/Networkdirectory/rainer.doffinger%40cam.ac.uk23 Feb 2024: IRF8 mutations and human dendritic-cell immunodeficiency. N Engl J Med. 2011 Jul 14;365(2):127-38. ... The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency. -
tb.med.cam.ac.uk/wp-json/wp/v2/posts/451
tb.med.cam.ac.uk/wp-json/wp/v2/posts/451{"id":451,"date":"2010-03-05T13:41:07","date_gmt":"2010-03-05T13:41:07","guid":{"rendered":"http://tb.med.cam.ac.uk/?p=451"},"modified":"2015-06-25T11:47:52","modified_gmt":"2015-06-25T10:47:52","slug":"welcome","status":"publish","type":"post","link -
B cells that exacerbate Streptococcal pneumoniae infection
https://www.medschl.cam.ac.uk/study-of-rare-monogenic-immunodeficiency-reveals-population-of-b-cells-that-exacerbate-streptococcal-pneumoniae-infection/23 Feb 2024: Site Search. Study of rare monogenic immunodeficiency reveals population of B cells that exacerbate Streptococcal pneumoniae infection. ... School of Clinical Medicine. Featured Articles. Study of rare monogenic immunodeficiency reveals population of B -
Unexpected matrix protein rearrangements seen in structures from…
https://www2.mrc-lmb.cam.ac.uk/unexpected-matrix-protein-rearrangements-seen-in-structures-from-intact-hiv-1-virus/6 Aug 2021: Human immunodeficiency virus type 1 (HIV-1) can cause persistent infections and result in acquired immunodeficiency syndrome (AIDS). ... Despite many years of intensive study, there is currently no vaccine against HIV-1 and it continues to be a major -
https://www.citiid.cam.ac.uk/wp-json/wp/v2/pages/7145
https://www.citiid.cam.ac.uk/wp-json/wp/v2/pages/7145The team is also characterising the virology of key spike protein mutations in new variants and their impact on natural and vaccine induced immunity./pnpRavi Gupta is a co-opted member ... strongAge-related immune response heterogeneity to SARS-CoV-2 -
Common Values - Funder | Research Operations Office
https://www.research-operations.admin.cam.ac.uk/costing-and-pricing-research-proposal/x5/common-values/funder10 May 2024: DOWCOUPE. DOWAGER COUNTESS ELEANOR PEEL TRUST. DOWNSYN. DOWN'S SYNDROME ASSOCIATION. 5671. ... EUSIMM. European Society of Immunodeficiencies. ESICM. EUROPEAN SOCIETY OF INTENSIVE CARE MEDICINE. -
First name(s)
https://www.oh.admin.cam.ac.uk/files/ohf18.pdf20 Sep 2023: Hepatitis B (HBV), hepatitis C (HCV) and the human immunodeficiency virus (HIV) are all bloodborne viruses (BBVs) that can be transmitted to patients from an untreated infected health care worker (HCW) ... HIV infection is a chronic condition which over -
https://www.immunology.cam.ac.uk/taxonomy/term/17/feed
https://www.immunology.cam.ac.uk/taxonomy/term/17/feed23 Feb 2024: www.ncbi.nlm.nih.gov/pubmed/29084722" rel="noopener noreferrer external" target="_blank">DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of ... Hapfelmeier, R.G. Jones, C. Hess. Memory CD8+ T Cells Require -
ohf18
https://www.oh.admin.cam.ac.uk/files/ohf18.docx22 Sep 2023: Hepatitis B (HBV), hepatitis C (HCV) and the human immunodeficiency virus (HIV) are all bloodborne viruses (BBVs) that can be transmitted to patients from an untreated infected health care worker (HCW) ... HIV infection is a chronic condition which over -
https://www.immunology.cam.ac.uk/taxonomy/term/43/feed
https://www.immunology.cam.ac.uk/taxonomy/term/43/feed23 Feb 2024: JA, Lehner PJ (2014) TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I. ... and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study.<span>Lancet</span>. -
https://www.cardiovascular.cam.ac.uk/taxonomy/term/51/feed
https://www.cardiovascular.cam.ac.uk/taxonomy/term/51/feed23 Feb 2024: Cambridge Cardiovascular - Wellcome Sanger Institute https://www.cardiovascular.cam.ac.uk/institutions/dir-sanger en Jack Palmer https://www.cardiovascular.cam.ac.uk/staff/jack-palmer <div class="field field-name-body field-type-text-with-summary -
The Academy of Medical Sciences announces election of new Fellows…
https://www-neurosciences.medschl.cam.ac.uk/blog/the-academy-of-medical-sciences-announces-election-of-new-fellows-2021/23 Feb 2024: the process by which new variants likely arise, and also reporting the first data on Pfizer BioNTech vaccine-induced antibody responses against the B.1.1.7 ‘Kent UK’ variant. ... His research investigates the basis for pathological immune activation -
tb.med.cam.ac.uk/wp-json/wp/v2/pages/386
tb.med.cam.ac.uk/wp-json/wp/v2/pages/386S. #. , Durandy A. #. (. #. corresponding authors):Occurrence of B-cell lymphomas in patients with activated phosphoinositide 3-kinase u03b4 syndrome. ... Thrasher AJ, Gaspar HB, Nejentsev S:Immunodeficiency and disseminated mycobacterial infection -
https://www.immunology.cam.ac.uk/taxonomy/term/11/feed
https://www.immunology.cam.ac.uk/taxonomy/term/11/feed23 Feb 2024: Cambridge Immunology Network - Immunogenetics https://www.immunology.cam.ac.uk/Networkdirectory/research-themes/immunogenetics The complex effects of genotype on phenotype in immunology Every immunologist makes use of genetics at some level but the -
tb.med.cam.ac.uk/blog/category/home-page-message/feed/
tb.med.cam.ac.uk/blog/category/home-page-message/feed/25 Jun 2015: protecting from infection./p pstrongGenetic analyses of patients with Primary Immunodeficiencies/strong/p pPrimary Immunodeficiencies (PIDs) comprise a heterogeneous group of genetic disorders that affect functioning of the immune system and -
https://www.immunology.cam.ac.uk/taxonomy/term/40/feed
https://www.immunology.cam.ac.uk/taxonomy/term/40/feed23 Feb 2024: www.ncbi.nlm.nih.gov/pubmed/29084722" rel="noopener noreferrer external" target="_blank">DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of ... blank">Simian Immunodeficiency Virus envelope glycoprotein -
https://www.immunology.cam.ac.uk/taxonomy/term/25/feed
https://www.immunology.cam.ac.uk/taxonomy/term/25/feed23 Feb 2024: Hapfelmeier, R.G. Jones, C. Hess. Memory CD8+ T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function. ... Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. -
Cambridge-Africa Activity Map :: Cambridge-Africa
https://www.cambridge-africa.cam.ac.uk/initiatives/project-map/Functional studies of a potential blood stage malaria vaccine candidate. Dr Julian C. ... Contribution of strain diversity to rotavirus vaccine effectiveness in Ghana: Investigating human rotavirus reservoirs and strain diversity in farm animals. -
Version 8.0 19/11/2014 Study Title: NIHR BioResource - Rare ...
https://www.neurology.cam.ac.uk/wp-content/uploads/2015/03/NIHRBR_RD-Protocol_V8_19_11_14.docx16 Jan 2024: 2. Addition of addendum 14.0 to include a new NIHRBR-RD project, Paediatric bone marrow failure syndrome (SMD). -
Legend
https://www.mrc-mbu.cam.ac.uk/files/buddy-2021q4-20211001-dist_0.xlsx4 Oct 2021: in Mitochondria [PMID:28712724]; Lack of the mitochondrial protein acylglycerol kinase causes Sengers syndrome [PMID:22284826];. ... Secondary. Mitochondrial membranes. Dynamics; homeostatis; QC. Green. Perrault syndrome 3, 614129 (3), Autosomal recessive
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