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https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/21839
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/21839{"id":21839,"date":"2021-12-03T12:01:37","date_gmt":"2021-12-03T12:01:37","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=21839"},"modified":"2021-12-03T12:01:39","modified_gmt":"2021-12-03T12:01:39","slug":"professional-registration-and-awards -
Imagining The Brain 2011
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/ImaginingTheBrain/2011/history.phpYvonne comes to the Sixth Form annually and gives talks structured around the requirement of the Theory of Knowledge component of the International Baccalaureate. ... See the gallery of 2011 entries and the Artist in Residence work. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/2798
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/2798{"id":2798,"date":"2012-09-12T10:49:57","date_gmt":"2012-09-12T09:49:19","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/wordpress/?page_id=2798"},"modified":"2024-01-19T12:41:59","modified_gmt":"2024-01-19T12:41:59","slug":"funding","status":"publ -
ProSHADE: ProSHADE Documentation
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/proshade/doxygen/index.html1 Nov 2018: Due to the requirement for the second stucture movement and rotation, it is worth noting that the structure may need to be re-sampled and/or moved to the same viewing ... std::vector<double> rotFunDists = run->getRotFunctionDists ( );. The vector -
Imagining The Brain 2012
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/ImaginingTheBrain/2012/criteria.phpYvonne comes to the Sixth Form annually and gives talks structured around the requirement of the Theory of Knowledge component of the International Baccalaureate. ... You will be asked to attend a prize giving ceremony at the MRC and we will retain the -
How To Apply - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/students/international-phd-programme/how-to-apply/6 Sep 2023: Step one entrance requirements. Please see the detailed entrance requirements to check you have the qualifications we require from our graduate entrants. ... Postgraduate Office,. MRC Laboratory of Molecular Biology,. Francis Crick Avenue,. Cambridge
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Imagining The Brain 2011
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/ImaginingTheBrain/2011/criteria.phpYou will be asked to attend a prize giving ceremony at the MRC and we will retain the artwork of the winning entries. ... If your art is also part of the requirements for your GCSE, AS, A level or IB course, you will have it returned to your school or -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/227
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/227{"id":227,"date":"2012-06-25T12:46:57","date_gmt":"2012-06-25T11:46:29","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/wordpress/?page_id=227"},"modified":"2024-04-04T16:31:10","modified_gmt":"2024-04-04T15:31:10","slug":"student-placement-scheme" -
Public Engagement - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/news-events/public-engagement/feed/28 Jun 2024: Our goal was to understand the mechanisms of viral entry, fusion, and structural maturation./p pWhy did you change focus to work on COVID-linked research?/p p style="padding-left: -
Protein-driven membrane stresses in fusion and fission
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Kozlov%20Trends%20Biochem%20Sci%202010.pdf20 Nov 2010: Proteins as energy generators for membraneremodelingMembrane remodeling, either by fusion or fission, canoccur if two physical requirements are fulfilled. ... Thereare two important requirements for this mechanism ofmembrane fusion. First, the -
N402_18f 313..320
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/10580505.pdf11 Nov 1999: protein kinase Lck30 (PDB entry 3lck). c, Stereo diagram of PI3Kg active site with bound. ... Different structural requirements within the switch II region of the Ras protein for. -
Target Selection during Protein Quality Control
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/96_Shao_S_TIBS_2016.pdf18 Feb 2016: In yeast, Sgt2 clients can be trans-ferred to the TRC40 homolog Get3 (guided entry of tail-anchored proteins 3) via the Get4–Get5bridging complex, with Get5 recruiting Sgt2 and Get4 ... This dual requirement wouldsharpen client discrimination by -
FtsA forms actin-like protofilaments
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/EMBO2012FtsAPiotr/emboj201276a.pdf27 Mar 2012: the requirement for ZipA, which is another Z-ring membrane. anchor in E. -
coot-user-manual.dvi
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/docs/coot-user-manual.pdf28 Sep 2012: 11.2 What is Coot? 11.3 What Coot is Not. 11.4 Hardware Requirements. ... 1.4 Hardware Requirements. The code is designed to be portable to any Unix-like operating system. -
Membrane transport between compartments in eukary-otic cells requires …
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Dynaminreview2004.pdf2 Feb 2004: Membrane transport between compartments in eukary-otic cells requires proteins that allow the budding andSCISSION of nascent cargo vesicles from one compartmentand their targeting and fusion with another. Just asSNARES are proposed to be essential -
doi:10.1016/j.molcel.2004.08.004
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/15350214.pdf24 Sep 2004: The observedsubstrate inhibition by Ins(1,4,5)P3 and non-linear kinetics with ATP(data not shown) may be caused by a requirement for ATP to bindbefore -
Biochem. J. (2011) 440, 185–193 (Printed in Great Britain) ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/ChernomordikBJ2011.pdf15 Nov 2011: and gp64-mediated fusion processes are triggered bytreating HA- or gp64-expressing cells with a low pH mediumthat mimics conditions in acidified endosomes during viral entry.In these fusion processes, the -
Tail-anchored membrane protein insertion into the endoplasmic…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/77_Hegde_RS_NRMCB_2011.pdf16 Nov 2011: insertion into the ER43. Although this and subsequent studies showed that insertion was protein and ATPdependent43–46, the molecular basis of this energy requirement and the factors involved in insertion remained ... The high level of conservation -
JFCregg_OGS_finaledit
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/Cregg_thesis.pdf14 Dec 2010: Caenorhabditis Elegans. A dissertation submitted in partial satisfaction of the. requirements for the degree Doctor of Philosophy. ... entry’ to the UK for five months. Dr. Arnivan Ghosh for his ability as a committee. -
nrm2162.indd
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17450176.pdf14 Jun 2007: Many plasma-membrane proteins are in a constant flux throughout the internal trafficking pathways of the cell. Some receptors, such as that for transferrin, are continuously internalized into recycling endosomes and returned to the cell surface. -
Cell, Vol. 85, 217–228, April 19, 1996, Copyright 1996 ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/5_Hegde_RS_Cell_1996.pdf25 Apr 1997: Furthermore, because the epi-and its entry into the translocation channel, whereas a. ... Although the length of time that the nents, demonstrated the requirement for a surprisinglychain is exposed to the cytosol is brief, it is significant. -
16262551036386 1..32
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/cohesin%20folding%202021%20elife-67268-v1.pdf14 Jul 2021: Shi et al., 2020; Higashi et al., 2020) and does so in the absence of Scc3 without entry inside the. ... chore protein Ctf19, a requirement that is apparently not bypassed by smc1D588Y. -
Cellular/Molecular Endophilin Drives the Fast Mode of Vesicle…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Llobet%20J%20Neurosci2011.pdf23 Sep 2011: All data are expressed as mean SEM Entries in bold are significantly different from the other conditions using a one-way ANOVA followed by Dunnett’s multiple-comparisons test (p ... J Neurosci Methods76:1–5. Sato K, Ernstrom GG, Watanabe S, Weimer RM, -
Substrate-driven assembly of a translocon for multipass membrane…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2023/08/Nature_2022b.pdf19 Aug 2023: The ER also contains members of the Oxa1 superfamily of TMD insertases9, including the guided entry of tail anchored protein (GET) complex10, the ER membrane protein complex (EMC)11 and TMCO1 ... 2f and Extended Data Fig. 4b). This is consistent with the -
The Function, Structure, and Origins of the ER Membrane Protein…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2023/08/Annual_Rev_Biochem_2022.pdf11 Apr 2022: investigation of tail-anchored (TA)membrane protein insertion by the GET (guided entry of TA protein) pathway provided anunexpected insight that ultimately led to the discovery of a key EMC function. ... Although GET3and EMC2 are unrelated proteins, they -
Molecular Biology of the CellVol. 19, 3463–3476, August 2008 ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/51_Ashok_A_MBC_2008.pdf16 Jul 2008: Molecular Biology of the CellVol. 19, 3463–3476, August 2008. Retrotranslocation of Prion Proteins from the EndoplasmicReticulum by Preventing GPI Signal TransamidationAarthi Ashok and Ramanujan S. Hegde. Cell Biology and Metabolism Program, -
Membrane Protein Insertion at the Endoplasmic Reticulum
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/75_Shao_S_Ann_Rev_2011.pdf9 Nov 2011: This strongly disfavors its translocation into the lumen, a requirement for sampling the type Itopology. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/24
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/24{"id":24,"date":"2012-06-25T09:57:52","date_gmt":"2012-06-25T09:57:52","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/wordpress/?page_id=24"},"modified":"2023-07-21T12:49:26","modified_gmt":"2023-07-21T11:49:26","slug":"manuscripts-correspondence" -
Protein targeting and degradation are coupled for elimination of…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/73_Hessa_T_Nature_2011.pdf14 Jul 2011: 2e andSupplementary Fig. 13), correlating with the requirements for ubiqui-tination (Fig. ... 4f). Ribosomessynthesizing nascent membrane proteins can recruit both the SRPand Bag6 complex on entry of the first hydrophobic segment intothe ribosomal tunnel4 -
doi:10.1016/j.devcel.2005.09.001
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/37_Shaffer_KL_DevCell_2005.pdf7 Oct 2005: 2002), different requirements for ac-cessory translocon components such as TRAM (Voigtet al., 1996) or the TRAP complex (Fons et al., 2003),and the choice of translocation pathway taken by thesubstrate ... In fact, since the signal sequences of Crtnd -
JCB: Article The Rockefeller University Press $30.00J. Cell Biol. ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/J%20Cell%20Biol%202010%20Howes.pdf24 Aug 2011: 6 F). To test the requirement for CLIC endocytosis during mi-gration, this inactivation assay was applied to migrating fibro-blasts. -
Dbouk 1..13
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/vadas_science_signaling.pdf5 Dec 2012: The inhibitoryactivity of the myristoylated peptide required its entry into the cells be-cause both myristoylated and TAT-tagged peptides inhibited Gbg-dependentactivation of Akt, whereas unmodified peptide had no such ... With regard to the requirement -
, 130081, published 7 August 20133 2013 Open Biol. ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Open%20Biol.-2013-TakedaCombined.pdf25 Sep 2013: 130081, published 7 August 20133 2013 Open Biol. Harvey T. McMahon and David M. GloverTetsuya Takeda, Iain M. Robinson, Matthew M. Savoian, John R. Griffiths, Anthony D. Whetton, the plasma membrane and contractile ring in cytokinesis. F-BAR protein -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/20739
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/20739{"id":20739,"date":"2021-07-29T11:20:57","date_gmt":"2021-07-29T10:20:57","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=20739"},"modified":"2021-07-29T11:20:57","modified_gmt":"2021-07-29T10:20:57","slug":"testing-the-capacity-for-intracellul -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/12771
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/12771However we are mindful that the extent of research opportunities can vary a lot as do the length undergraduate courses, master requirements, and all these are put into context when evaluating ... nnnn. If you have heard of us, spread the word or enrol -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/19288
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/19288{"id":19288,"date":"2020-10-23T13:47:37","date_gmt":"2020-10-23T12:47:37","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=19288"},"modified":"2021-11-18T14:49:58","modified_gmt":"2021-11-18T14:49:58","slug":"opening-of-lmb-containment-level-3-l -
Manuscripts & Correspondence - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/archive/manuscripts-correspondence/21 Jul 2023: Gonville and Caius. July 1953. Bound photocopy. Miscellaneous collection of Crick material has been collected by Mark Bretscher – see entry under BRETSCHER, Mark. ... Dissertations submitted for the degree of Doctor of Philosophy in the University of
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Key Dates for Applicants - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/students/international-phd-programme/key-dates-for-applicants/6 Sep 2023: 22nd December 2023 – 3rd January 2024. LMB Postgraduate Office Christmas closure.
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Overview of admissions - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/students/international-phd-programme/overview-of-admissions/12 Sep 2023: However we are mindful that the extent of research opportunities can vary a lot as do the length undergraduate courses, master requirements, and all these are put into context when evaluating ... If you have heard of us, spread the word or enrol for the
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Electron Cryo-microscopy - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/news-events/public-engagement/cryo-electron-microscopy/feed/28 Jun 2024: Our goal was to understand the mechanisms of viral entry, fusion, and structural maturation./p pWhy did you change focus to work on COVID-linked research?/p p style="padding-left: -
HARVEY T McMAHON CV
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/people/CV2008c.htm28 Jul 2008: I participate in lectures to postgraduate students both within our own institute and in other MRC institutes. ... 2+. entry. Neuron 6, 517-524 (1991). 11. McMahon, H.T. and Nicholls, D.G. -
The Coot User Manual
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/docs/coot.html1 Mar 2021: Hardware Requirements:. • Environment Variables:. • Command Line Arguments:. • Web Page:. • -
Professional registration and awards: Celebrating the Technician’s…
https://www2.mrc-lmb.cam.ac.uk/professional-registration-and-awards-celebrating-the-technicians-commitment-at-the-lmb/3 Dec 2021: Leading the way if you like. Since passing the competency report as part of the registered technician entry requirement, I have become a Member of the Institute of Science and Technology ... The hardest part was relating what I did in my current job role
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Contents:
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/balbes/documentation_fs/manual_115.html31 Jan 2012: We update and release the internal database of BALBES for homologous searching every month to include entries related to new structures released by Protein Data Bank(PDB). ... The requirements depend on what you want to do with BALBES. -
Testing the capacity for intracellular antibodies to neutralise…
https://www2.mrc-lmb.cam.ac.uk/testing-the-capacity-for-intracellular-antibodies-to-neutralise-sars-cov-2/29 Jul 2021: Standard assays for antibody neutralisation examine the ability of antibodies to directly block the entry of a virus into a cell. ... Although this assay is not suitable for population screening due to its requirement for CL3 lab space and use of live
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Molecular basis for membrane remodelling and organization
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/F-BAR_proteins/JMConference/speakerprofiles.html21 Nov 2010: Cell. 2008 Mar 7;132(5):807-17. A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. ... Traffic. 2007 Oct;8(10):1385-403. Entry mechanisms for toxins and viruses, and the role of membrane curvature. -
ProSHADE: ProSHADE_internal::ProSHADE_distances Class Reference
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/proshade/doxygen/d1/d6f/class_pro_s_h_a_d_e__internal_1_1_pro_s_h_a_d_e__distances.html1 Nov 2018: It returns a vector of vectors of energy level distances from the fragment to all passing database entries. ... It returns a vector of vectors of trace sigma distances from the fragment to all passing database entries. -
30 Apr 2004 18:9 AR AR214-BB33-09.tex AR214-BB33-09.sgm…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/annrev2004.pdf1 May 2004: have similar, almost exchangeable functions, asdemonstrated recently by a gain-of-function point mutation in FtsA that removesthe requirement for ZipA completely (45). ... maritima(Figure 10). The protein was found to polymerizeeasily under mild -
PII: S0014-5793(01)02216-5
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/MinD%20FEBS.pdf5 Mar 2001: 3. Results. Structurally MinD closely resembles other nucleotide bind-ing proteins such as nitrogenase iron proteins and GTPasessuch as Ffh (PBD entry 1NG1 [20]), part of the signal recog-nition particle ... The nucleotide binding surface of MinD is the -
Opening of LMB Containment Level 3 lab fast-tracked to help fight the …
https://www2.mrc-lmb.cam.ac.uk/opening-of-lmb-containment-level-3-lab-fast-tracked-to-help-fight-the-covid-19-pandemic/23 Oct 2020: sure the laboratory met all legal requirements. ... Leo: In the context of COVID-19, everyone is looking at the spike protein – which coats the outside of the virus particle and mediates cell entry – and how spike antibodies stop
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