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20 May 2024: Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: The Y220X Paradigm. ... doi:A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.

20 May 2024: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... We discovered that about 30% of oncogenic mutants of p53 are just temperatures sensitive and can, in theory, be rescued by small molecules.

20 May 2024: D Klenerman. – eLife. Characterization of full-length p53 aggregates and their kinetics of formation.

20 May 2024: 130,. 194508. (doi: 10.1063/1.3131690). Computer Simulations of Peptides from the p53 DNA Binding Domain.

20 May 2024: Imaging aggregates of P53 and determining the role of these aggregates in the development and spreading of cancer.

20 May 2024: Nature neuroscience. (2022). 25,. 1582. (doi: 10.1038/s41593-022-01206-2). Characterization of full-length p53 aggregates and their kinetics of formation.

20 May 2024: 1474. (doi: 10.1016/j.bpj.2020.09.007). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation.

20 May 2024: His work is now focussed on how mutation affects proteins in the cell cycle, particularly the tumour suppressor p53 – the so-called “Guardian of the Genome” – in order to design novel

31 Oct 2013: We discov-ered that normal p53 in a cell melts at44C, only just above body tempera-ture. ... p53 inactive simply make it less stable,and start melting at body temperatureor below.’.

4 Jan 2016: N. N. Br. BrN. EtO. OMe. O N. OH. Figure 4 left: crystal structure of MDM2-p53 (1YCR), middle: crystal structure of MDM2-Nutlin-2 (1RV1), right: Nutlin-2!