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21 Jul 2023: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53..

20 May 2024: Alan Fersht - Tumour suppressor p53 structure and drug discovery.

21 Jul 2023: Tumour suppressor p53 structure and drug discovery. LMB Division - Protein and Nucleic Acid Chemistry.

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26 Jan 2021: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... Tumour Suppressor p53. Structural Biology and Drug Discovery. Alan Fersht. MRC Laboratory of Molecular Biology.

n. Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... We discovered that about 30% of oncogenic mutants of p53 are just temperatures sensitive and can, in theory, be rescued by small molecules.

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n. Professor Sir Alan Fersht, FRS, from the PNAC Division of LMB, has been awarded an Advanced ERC Grant of u20ac1.5m for his project u201cTumour suppressor p53: structure, stability and ... 70% of human cancers have p53 directly inactivated by mutation.

can bind to and deactivate an enzyme that controls the stability of the p53 tumour suppressor protein. ... This deactivation allows p53 to be turned on, putting the brakes on cancer growth.

20 Oct 2017: can bind to and deactivate an enzyme that controls the stability of the p53 tumour suppressor protein. ... This deactivation allows p53 to be turned on, putting the brakes on cancer growth.

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3 May 2024: Valle (2011) "Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA".

2 Jun 2011: Second row: p53 group members and Alan cutting cake.Third row: Ada Yonath, Hualiang Jiang, Jianpeng Ma and Sarah Perrett. ... Fourth row: Amnon Horovitz, Qinghua Wan and p53 group members; Bottom row: Qinghua Wang, Marilyn Fersht, Qinghua Wang, Jianpeng

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26 Nov 2010: Alan’s grant complements his MRC programme grant on the “Structural Biology of p53”, which started on 1 October 2010. ... 70% of human cancers have p53 directly inactivated by mutation. Alan’s group has found that some 30% of the inactivated

In additional experiments we were able to cage a key lysine in a nuclear localization signal in p53, and define the contribution of that signal to the kinetics of nuclear import.

4 Jan 2018: This result suggests that the critically important p53 stress response in stem cells fundamentally differ from the response seen in other cells. ... In addition, the new insight into the function of p53 in blood stem cells may explain why certain blood

11 May 2017: the damage, including arresting the cell cycle by phosphorylating the checkpoint kinase CHK2 and, under some conditions, inducing apoptosis by phosphorylating p53 and preventing its degradation. ... Using p53 produced by Tomas Kouba in Alan Fersht’s

17 Sep 2020: 2020) A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation Stem Cell Reports 32888504.

a protein to control its function.u00a0 In additional experiments we were able to cage a key lysine in a nuclear localization signal in p53, and define the contribution of that

24 Sep 2010: Alan will continue to lead his research on the p53 tumour suppressor protein at the LMB with an MRC programme grant for the next five years.

4 Aug 2020: Alan’s most recent interest is in the tumour suppressor p53, with the aim to understand how mutations affect its function, so that novel anti-cancer drugs may be designed to

Chin, W. Fischle, S.M. Gasser. Acetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration.

24 Nov 2021: Inset, model of the molecular mechanism by which ADH5 and CSB cooperate to protect cells from damage, which is sensed by the stalled transcription machinery and can trigger p53 dependent activation

3 Apr 2024: Fischle, S.M. Gasserem. /em/p p(53)strongAcetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration./strongbr / a

Chin, W. Fischle, S.M. Gasser. (53) Acetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration.

Fischle, S.M. Gasserem. u00a0/em/pnpstrongAcetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration./strongbr /na

Fischle, S.M. Gasserem. u00a0/em/pnp(53)u00a0strongAcetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration./strongbr /na

22 Oct 2002: Johnstone, R.W., Ruefli, A.A., and Lowe, S.W. (2002). Cell 108,roles of Rb and p53 and provides molecular clues as to 153–164.how these famous tumor suppressors ... 2000). Carcinogenesis 21, 485–495.regulatory pathway involving p53, Rb, BH3-only

12 Nov 2006: pro-survival molecule BclXL. Similar negative regulation of YAP (not. shown) leads to repression of the p53 related transcription factor p73. ... reciprocal changes in the classic NF-kB pro-survival pathway and the. pro-apoptotic p53 pathway.

11 Nov 1999: Barrett, J. C. Differential regulation of p21 by p53 and Rb in cellular. ... et al. Involvement of p85 in p53-dependent apoptotic response to oxidative stress.

19 Nov 2019: Krstic-Demonacos, N. B. La Thangue, A TPR motif cofactor contributes to p300 activity in the p53 response. ... Knapp, N. B. La Thangue, A. N. Bullock, The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.

12 Nov 2009: 2007) G10, G11 i. CRY P53 domain 6.5 27.0 CPE, Joel Kaar &Nicolas Basse.

29 Jan 2024: Chin, W. Fischle, S.M. Gasser. EMBO J. 2011. 30: 2610-2621. (53) Acetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration.

16 Oct 2009: early in DNA damage response and regulateRAP80 localization. Many cell cycle checkpoint proteins, includingATM, Chk2, BRCA1, and p53, play critical rolesin the maintenance of genomic stability.

19 Dec 2016: By default, the applet shows details of a test Delta screen (Delta screen p53) which contains PEG3350 as precipitant, glycerol as cryoprotectant, etc. ... In Delta screen p53, component 7 is a cryoprotectant (glycerol). The concentration of

1 Dec 2019: Circ Genom Precis Med. 2019;12:e002507. DOI: 10.1161/CIRCGEN.119.002507 September 2019 397. BACKGROUND: Pediatric cardiomyopathies are a clinically and genetically heterogeneous group of heart muscle disorders associated with high morbidity and

22 Jul 2007: with KRAS (G13D) and P53(S241F) mutations). These lines. were infected with retrovirus expressing iDab#6-memb, and.

21 Nov 2012: Cooperation between Pik3ca and p53 mutations in mousemammary tumor formation. Cancer Res 71: 2706–2717.

27 Apr 2009: Recent findings have shown that proteinsoriginally shown to be important regulators ofmore diverse cellular phenomena, e.g., apopto-sis (p53) (32), asymmetric cell division (numb)(26), or cell polarity (par proteins)