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1 - 7 of 7 search results for p53 |u:www.bioc.cam.ac.uk

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  2. p53 impairs CRISPR/Cas9 in healthy cells | Department of Biochemistry

    https://www.bioc.cam.ac.uk/news/archive/2018/p53-impairs-crispr-cas9-in-healthy-cells
    13 Jun 2024: RPE-1) cell line activate p53, causing cell growth arrest and DNA repair via the NHEJ pathway. ... A delicate balance is required, however, as p53 inhibition can leave cells vulnerable to tumorigenic mutations.

  3. Gerard Evan | Department of Biochemistry

    https://www.bioc.cam.ac.uk/research/evan
    13 Jun 2024: I. (2013). Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy. ... 2011). Validation of MdmX as a therapeutic target for reactivating p53 in tumors.

  4. Publications | Department of Biochemistry

    https://www.bioc.cam.ac.uk/mottowen/publications
    13 Jun 2024: Owen. 1996. R.J.A. Grand, D. Owen, S.M. Rookes & P.H. Gallimore (1996) "Control of p53 expression by Adenovirus-12 early region 1A and early region 1B 54K proteins" ... Levine & Gallimore, P.H. (1995) "The high levels of p53 present in Adenovirus early

  5. Aims and Objectives | Department of Biochemistry

    https://www.bioc.cam.ac.uk/teaching/fourth-year/biochemistry/guidance
    13 Jun 2024: Cancer studies. Including cell cycle and cancer, use of mouse models, genome-wide sequencing and genome-wide disease association, leukaemia, p53, cancer therapeutics, recombinant antibody generation, commercial drug design and development,

  6. Svetlana Khoronenkova | Department of Biochemistry

    https://www.bioc.cam.ac.uk/research/khoronenkova
    13 Jun 2024: ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.

  7. MIMS 07 Lecture Timetable

    https://www.bioc.cam.ac.uk/sites/www.bioc.cam.ac.uk/files/mims_course_overview_2022-23.pdf
    24 Oct 2022: Transcription factors and cancer – cFos/c-Jun, p53. Lecture 3: Pre-mRNA processing – from pre-RNA to mature mRNA.

  8. Jussi Taipale | Department of Biochemistry

    https://www.bioc.cam.ac.uk/research/taipale
    13 Jun 2024: CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response. Nat. Med., 24(7):927-930.

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