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1 - 10 of 12 search results for p53 |u:www.ch.cam.ac.uk

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  2. Professor Sir Alan Fersht FRS | Yusuf Hamied Department of Chemistry

    https://www.ch.cam.ac.uk/person/arf25
    17 Jun 2024: Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. ... 2019). 21,. 5. (doi:A Structure-Guided Molecular Chaperone Approach for Restoring the Transcriptional Activity of the p53 Cancer Mutant Y220C.

  3. Alan Fersht | 03 - 05 Sept 2017 Cambridge, UK

    https://www.ch.cam.ac.uk/pfei/alan-fersht
    17 Jun 2024: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... We discovered that about 30% of oncogenic mutants of p53 are just temperatures sensitive and can, in theory, be rescued by small molecules.

  4. Publications | Centre for Experimental Biophysical Chemistry

    https://www.ch.cam.ac.uk/biophyschem/publications?page=50
    17 Jun 2024: doi: 10.1016/0009-2614(86)80452-3). Characterization of full-length p53 aggregates and their kinetics of formation.

  5. Professor Sir David Klenerman FMedSci FRS | Yusuf Hamied Department…

    https://www.ch.cam.ac.uk/person/dk10012
    17 Jun 2024: Imaging aggregates of P53 and determining the role of these aggregates in the development and spreading of cancer.

  6. Publications | Centre for Experimental Biophysical Chemistry

    https://www.ch.cam.ac.uk/biophyschem/publications?page=4
    17 Jun 2024: Nature neuroscience. (2022). 25,. 1582. (doi: 10.1038/s41593-022-01206-2). Characterization of full-length p53 aggregates and their kinetics of formation.

  7. Publications | Wales Group

    https://www.ch.cam.ac.uk/group/wales/publications?page=14
    17 Jun 2024: 194508. (doi: 10.1063/1.3131690). Computer Simulations of Peptides from the p53 DNA Binding Domain.

  8. Publications | Clarke Group

    https://www.ch.cam.ac.uk/group/sclarke/publications?page=2
    17 Jun 2024: 1474. (doi: 10.1016/j.bpj.2020.09.007). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation.

  9. Publications | Centre for Atmospheric Science

    https://www.ch.cam.ac.uk/group/atm/publications?page=14
    17 Jun 2024: Weather. (2020). 75,. 353. (doi: 10.1002/wea.3795). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation.

  10. Protein engineering pioneer awarded Royal Society Copley Medal |…

    https://www.ch.cam.ac.uk/news/protein-engineering-pioneer-awarded-royal-society-copley-medal
    17 Jun 2024: His work is now focussed on how mutation affects proteins in the cell cycle, particularly the tumour suppressor p53 – the so-called “Guardian of the Genome” – in order to design novel

  11. Layout 1

    https://www.ch.cam.ac.uk/files/chematcam/CC33web.pdf
    31 Oct 2013: We discov-ered that normal p53 in a cell melts at44C, only just above body tempera-ture. ... p53 inactive simply make it less stable,and start melting at body temperatureor below.’.

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