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Publications
https://www2.mrc-lmb.cam.ac.uk/groups/jes/publications.html17 Sep 2020: 2020) A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation Stem Cell Reports 32888504. -
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-json/wp/v2/pages/52
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-json/wp/v2/pages/52a protein to control its function.u00a0 In additional experiments we were able to cage a key lysine in a nuclear localization signal in p53, and define the contribution of that -
LMB continues pioneering work started in CPE - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/lmb-continues-pioneering-work-started-in-cpe/24 Sep 2010: Alan will continue to lead his research on the p53 tumour suppressor protein at the LMB with an MRC programme grant for the next five years.
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Alan Fersht and Marta Zlatic win Royal Society Medals - MRC…
https://www2.mrc-lmb.cam.ac.uk/alan-fersht-and-marta-zlatic-win-royal-society-medals/4 Aug 2020: Alan’s most recent interest is in the tumour suppressor p53, with the aim to understand how mutations affect its function, so that novel anti-cancer drugs may be designed to
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Post-translational modifications
https://www2.mrc-lmb.cam.ac.uk/ccsb/research/post-translational-modifications/Chin, W. Fischle, S.M. Gasser. Acetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration. -
How DNA damage induces appetite suppression and weight loss - MRC…
https://www2.mrc-lmb.cam.ac.uk/how-dna-damage-induces-appetite-suppression-and-weight-loss/24 Nov 2021: Inset, model of the molecular mechanism by which ADH5 and CSB cooperate to protect cells from damage, which is sensed by the stalled transcription machinery and can trigger p53 dependent activation
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All publications
https://www2.mrc-lmb.cam.ac.uk/ccsb/publications/all-publications-2/Chin, W. Fischle, S.M. Gasser. (53) Acetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration. -
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-json/wp/v2/pages/46
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-json/wp/v2/pages/46Fischle, S.M. Gasserem. u00a0/em/pnpstrongAcetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration./strongbr /na -
Chin
https://www2.mrc-lmb.cam.ac.uk/ccsb/category/publications/feed/3 Apr 2024: Fischle, S.M. Gasserem. /em/p p(53)strongAcetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration./strongbr / a -
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-json/wp/v2/pages/312
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-json/wp/v2/pages/312Fischle, S.M. Gasserem. u00a0/em/pnp(53)u00a0strongAcetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration./strongbr /na
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