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can bind to and deactivate an enzyme that controls the stability of the p53 tumour suppressor protein. ... This deactivation allows p53 to be turned on, putting the brakes on cancer growth.

20 Oct 2017: can bind to and deactivate an enzyme that controls the stability of the p53 tumour suppressor protein. ... This deactivation allows p53 to be turned on, putting the brakes on cancer growth.

3 May 2024: Valle (2011) "Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA".

2 Jun 2011: Second row: p53 group members and Alan cutting cake.Third row: Ada Yonath, Hualiang Jiang, Jianpeng Ma and Sarah Perrett. ... Fourth row: Amnon Horovitz, Qinghua Wan and p53 group members; Bottom row: Qinghua Wang, Marilyn Fersht, Qinghua Wang, Jianpeng

nAlan will continue to lead his research on the p53 tumour suppressor protein at the LMB with an MRC programme grant for the next five years.

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In additional experiments we were able to cage a key lysine in a nuclear localization signal in p53, and define the contribution of that signal to the kinetics of nuclear import.

26 Nov 2010: Alan’s grant complements his MRC programme grant on the “Structural Biology of p53”, which started on 1 October 2010. ... 70% of human cancers have p53 directly inactivated by mutation. Alan’s group has found that some 30% of the inactivated

4 Jan 2018: This result suggests that the critically important p53 stress response in stem cells fundamentally differ from the response seen in other cells. ... In addition, the new insight into the function of p53 in blood stem cells may explain why certain blood