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Alan Fersht - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/alan-fersht/21 Jul 2023: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.. -
Protein and Nucleic Acid Chemistry - MRC Laboratory of Molecular…
https://www2.mrc-lmb.cam.ac.uk/research/protein-and-nucleic-acid-chemistry/20 May 2024: Alan Fersht - Tumour suppressor p53 structure and drug discovery. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/21808
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/21808{"id":21808,"date":"2021-11-24T16:17:22","date_gmt":"2021-11-24T16:17:22","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=21808"},"modified":"2024-04-12T12:09:08","modified_gmt":"2024-04-12T11:09:08","slug":"how-dna-damage-induces-appetite-supp -
Emeritus - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/21 Jul 2023: Tumour suppressor p53 structure and drug discovery. LMB Division - Protein and Nucleic Acid Chemistry. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/61
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/61{"id":61,"date":"2012-06-25T10:03:42","date_gmt":"2012-06-25T10:03:42","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/wordpress/?page_id=61"},"modified":"2024-05-20T14:39:16","modified_gmt":"2024-05-20T13:39:16","slug":"protein-and-nucleic-acid-ch -
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https://www2.mrc-lmb.cam.ac.uk/groups/fersht/26 Jan 2021: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... Tumour Suppressor p53. Structural Biology and Drug Discovery. Alan Fersht. MRC Laboratory of Molecular Biology. -
Scheres lab
https://www2.mrc-lmb.cam.ac.uk/groups/scheres/publications.html23 Jul 2024: Valle (2011) "Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA". -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/117
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/117n. Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... We discovered that about 30% of oncogenic mutants of p53 are just temperatures sensitive and can, in theory, be rescued by small molecules. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/11414
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/11414{"id":11414,"date":"2018-01-04T09:33:03","date_gmt":"2018-01-04T09:33:03","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/?p=11414"},"modified":"2020-11-19T16:55:54","modified_gmt":"2020-11-19T16:55:54","slug":"uncovering-alcohol-derived-metabolite -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/3320
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/3320n. Professor Sir Alan Fersht, FRS, from the PNAC Division of LMB, has been awarded an Advanced ERC Grant of u20ac1.5m for his project u201cTumour suppressor p53: structure, stability and ... 70% of human cancers have p53 directly inactivated by mutation.
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