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Professor Sir Alan Fersht FRS | Yusuf Hamied Department of Chemistry
https://www.ch.cam.ac.uk/person/arf2518 Jul 2024: Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. ... doi:A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C. -
Alan Fersht | 03 - 05 Sept 2017 Cambridge, UK
https://www.ch.cam.ac.uk/pfei/alan-fersht18 Jul 2024: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... We discovered that about 30% of oncogenic mutants of p53 are just temperatures sensitive and can, in theory, be rescued by small molecules. -
Publications | Wales Group
https://www.ch.cam.ac.uk/group/wales/publications?page=1418 Jul 2024: Computer Simulations of Peptides from the p53 DNA Binding Domain. M Khalili, DJ Wales. – -
Publications | Centre for Experimental Biophysical Chemistry
https://www.ch.cam.ac.uk/biophyschem/publications?page=518 Jul 2024: Nature Neuroscience. (2022). 25,. 1582. (doi: 10.1038/s41593-022-01206-2). Characterization of full-length p53 aggregates and their kinetics of formation. -
Professor Sir David Klenerman FMedSci FRS | Yusuf Hamied Department…
https://www.ch.cam.ac.uk/person/dk1001218 Jul 2024: Imaging aggregates of P53 and determining the role of these aggregates in the development and spreading of cancer. -
Protein engineering pioneer awarded Royal Society Copley Medal |…
https://www.ch.cam.ac.uk/news/protein-engineering-pioneer-awarded-royal-society-copley-medal18 Jul 2024: His work is now focussed on how mutation affects proteins in the cell cycle, particularly the tumour suppressor p53 – the so-called “Guardian of the Genome” – in order to design novel -
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https://www.ch.cam.ac.uk/files/chematcam/CC33web.pdf31 Oct 2013: We discov-ered that normal p53 in a cell melts at44C, only just above body tempera-ture. ... p53 inactive simply make it less stable,and start melting at body temperatureor below.’. -
Part II Exam Questions Reports 2018/19 (incomplete) Paper 1 ...
https://www.ch.cam.ac.uk/teaching/files/Examiners%20Reports/Part%20II_ExamReports%20_2018-19.pdf9 Jul 2024: The best students got this correct. Many students also thought the protein, p53 had disulphide bridges. ... p53 was covered in the lectures as a nuclear protein that bound DNA so they should have been aware it is in a reducing environment. -
Publications | Clarke Group
https://www.ch.cam.ac.uk/group/sclarke/publications?page=218 Jul 2024: 1474. (doi: 10.1016/j.bpj.2020.09.007). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation. -
Publications | Centre for Atmospheric Science
https://www.ch.cam.ac.uk/group/atm/publications?page=1418 Jul 2024: Weather. (2020). 75,. 353. (doi: 10.1002/wea.3795). A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation.
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