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2024 | University Biomedical Services (UBS)
https://www.ubs.admin.cam.ac.uk/home-office-licensing/non-technical-summaries/202430 Apr 2024: Search site. University Biomedical Services (UBS). 2024. Non-Technical Summaries 2024. generation_and_screening_of_companion_animal_therapeutics._non-technical_summary_redacted.pdf (175.18 KB). -
AWERB 3Rs Minutes 7th February 2024
https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_070224_redacted.pdf30 Apr 2024: further details could be included in section 3.7. 4. Project Licence Applications – New / Amendments. -
2023 | University Biomedical Services (UBS)
https://www.ubs.admin.cam.ac.uk/home-office-licensing/non-technical-summaries/202330 Apr 2024: new_treatments_for_renal_and_liver_disease_non-technical_summary_redacted.pdf (150.22 KB). -
AWERB 3Rs Minutes 3rd January 2024
https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_030124_redacted.pdf30 Apr 2024: 4. Retrospective Assessment. N/A. 5. Project Licence Applications – New / Amendments N/A. -
AWERB Standing Minutes 24th January 2024
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_240124_redacted.pdf30 Apr 2024: 1. Project Licences (a) New licence - ( was also in attendance) The committee discussed the following:. • ... b) Amendment - The committee discussed the following:. • Inclusion of any benefits that will be gained from this amendment that will balance -
AWERB Standing Minutes 28th February 2024_Redacted
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_280224_redacted.pdf30 Apr 2024: Project Licences (a) New licence: ( were also in attendance) The committee discussed the following:. • ... c) New Licence: The committee discussed the following:. • Further explanation required in regards to symbols used in the Aims section. • -
AWERB Standing Minutes 27th March 2024
https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_270324_redacted.pdf30 Apr 2024: Project Licences (a) New licence: was also in attendance) The committee discussed the following:. • ... Page 2 of 4. (b) New Licence: was also in attendance) The committee discussed the following:. • -
Axon degeneration and repair (non-technical summary)
https://www.ubs.admin.cam.ac.uk/system/files/public/axon_degeneration_and_repair_non-technical_summary_redacted.pdf30 Apr 2024: Our plan is to publish research papers with new information on which human diseases involve programmed axon death and which specific people are most at risk. ... As we have shown, when a new 3Rs method becomes available (e.g., hiPSC-derived neurons), we -
Placental epignetic programming
https://www.ubs.admin.cam.ac.uk/system/files/public/placental_epigenetic_programming_non-technical_summary_redacted.pdf30 Apr 2024: Our findings will help both clinical and basic science research in reproductive biology and epigenetics to generate new research questions. ... Culture methods for human placental trophoblast cells are very new and still under development. -
Early human development and the germline (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/early_human_development_and_the_germline_non-technical_summary_redacted.pdf30 Apr 2024: Human embryos are highly inaccessible for research. We use animals to test new experimental approaches, and the knowledge gained can be used to investigate similar events in precious human fetuses and ... We have reduced significantly the number of mice -
New treatments for renal and liver disease (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatments_for_renal_and_liver_disease_non-technical_summary_redacted.pdf30 Apr 2024: In work under this licence we aim to identify new treatments for CKD, AKI and NAFLD. ... project? We hope to optimise new imaging efficacy endpoints that will allow assessment of animals over time. -
In vivo compressive forces (non-technical summary)_Redacted
https://www.ubs.admin.cam.ac.uk/system/files/public/in_vivo_compressive_forces_non-technical_summary_redacted.pdf30 Apr 2024: For each stock a new generation will be grown every 18 months (3.3 generations per line in 5 years). ... For each we will breed a new generation every 18 months (2560x3.3=8448). -
Models of mitochondrial diseases, pathogenesis and therapy
https://www.ubs.admin.cam.ac.uk/system/files/public/models_of_mitochondrial_diseases_pathogenesis_and_therapy_non-technical_summary_redacted.pdf30 Apr 2024: 1. New mouse models of mitochondrial disease which carry mutations similar to those found in humans. ... The remaining 20% will be neonates (new born pups up to weaning - approx. -
Mechanisms controlling cell division and cell identity during…
https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_controlling_cell_division_and_cell_identity_during_development_reprogramming_and_disease_redacted.pdf30 Apr 2024: For example, understanding how cell identity can contribute to diseases may help in the discovery of new treatments. ... I am currently on the European Xenopus Resource Steering Committee where new developments in frog husbandry are often discussed. -
Understanding Infection Pathogenesis to Guide Therapies…
https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_infection_pathogenesis_to_guide_therapies_non-technical_summary_redacted.pdf30 Apr 2024: 6.1 million deaths annually (https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death). ... This is confounded by the fact that there have been very few new antimicrobial products that have been developed over the last 15 years. -
Mechanisms of organ development and disease (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_of_organ_development_and_disease_non-technical_summary_redacted.pdf30 Apr 2024: We will make a new generation for each line every year (5 generations per line). ... In addition, when generating new genetically modified lines, the F0 embryos need to be genotypically screened. -
Interaction between the immune system and tumours (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/interaction_between_the_immune_system_and_tumours_non-technical_summary_redacted.pdf30 Apr 2024: To the wider pharmaceutical industry and patients this could lead into the development of new anti-cancer therapies. ... Pilot studies are used to establish the correct dose of reagents/cells, timelines, and to generate baseline data for new experiments. -
PK and PKPD studies to support Respiratory and Immunology research
https://www.ubs.admin.cam.ac.uk/system/files/public/pk_and_pkpd_studies_to_support_respiratory_and_immunology_research_non-technical_summary_redacted.pdf30 Apr 2024: To enable us to decide what doses of new treatments we need to use in our respiratory and immunology disease models. ... There are multiple stages of non-animal screening of new molecules that are in place before testing in rodent. -
Neurobehavioural Mechanisms Underlying Mood, Impulsive and Compulsive …
https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_underlying_mood_impulsive_and_compulsive_mental_health_disorders_non-t_redacted.pdf30 Apr 2024: benefit people living with mental health disorders through the development of new treatments. ... We also expect, in the medium term, that our research will lead to the development of new behavioural treatments. -
Proteotoxicity in development and ageing (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/proteotoxicity_in_development_and_ageing_non-technical_summary_redacted.pdf30 Apr 2024: There is no cure for neurodegenerative disorders and thus, finding a new common target is at utmost importance. ... We have created new mouse lines with specific mutations in genes that disrupt one of the stress response pathway that is called
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