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MobiDB 3.0: more annotations for intrinsic disorder, conformational…
www-vendruscolo.ch.cam.ac.uk/piovesan2018nar.pdf22 Apr 2018: New curated data. MobiDB 3.0 includes different sources of manually curateddisorder annotations (Table 1). ... 2016) ELM 2016–data update and new functionality of theeukaryotic linear motif resource. -
OP-CBIO180177 2944..2950
www-vendruscolo.ch.cam.ac.uk/liberis2018b.pdf23 Sep 2018: tors b are parameters learned by the network. • The new cell state Ct and ht, as well as the output yt is given by:. ... IEEE, Athens, Greece. Xia,X. and Xie,Z. (2002) Protein structure, neighbor effect, and a new index. -
Systematic mapping of free energy landscapes of a growing filamin…
www-vendruscolo.ch.cam.ac.uk/waudby2018pnas.pdf27 Sep 2018: On addition of this enzyme,folding of 6 was no longer observed in real-time NMR exper-iments, but instead, new exchange cross-peaks were observedbetween N and U states in -
Distinct thermodynamic signatures of oligomer generation in the…
www-vendruscolo.ch.cam.ac.uk/cohen2018nc.pdf22 Apr 2018: The secondary nucleation process involves existing fibrils catalysing the nucleation of new aggregates from monomeric pep-tide. ... parameters are related to the rate of formation of new aggregates through primary pathways λ = k k m2 (0)n. -
SAR by kinetics for drug discovery in protein misfolding diseases
www-vendruscolo.ch.cam.ac.uk/chia2018pnas.pdf26 Sep 2018: V. contributed new reagents/analytic tools; S.C., J.H., T.C.T.M., S.I.A.C., S.L., C.M.D.,T.P.J.K., and M.V. -
Exploring the role of post‐translational modifications in regulating…
www-vendruscolo.ch.cam.ac.uk/elturk2018ps.pdf23 Sep 2018: findings provide new insights into the potential. applications of NbSyn87 in diagnostic and therapeu-. ... DG, de Yebenes JG (2004) The new mutation,E46K, of alpha-synuclein causes Parkinson and Lewybody dementia. -
A tau homeostasis signature is linked with the cellular and regional…
www-vendruscolo.ch.cam.ac.uk/fu2019nn.pdf18 Dec 2018: 2Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA. ... 7Division of Integrative Neuroscience, New York State Psychiatric Institute, New York, NY, USA. -
Cholesterol catalyses Aβ42 aggregation through a heterogeneous…
www-vendruscolo.ch.cam.ac.uk/habchi2018nc.pdf26 May 2018: In either type of primary nucleation, once a critical number of fibrils is formed, secondary nucleation becomes the major source for generating new oligomers. ... These two combinations define the intrinsic timescales associated with the proliferation of -
Third generation antibody discovery methods: in silico rational design
www-vendruscolo.ch.cam.ac.uk/sormanni2018csr.pdf18 Dec 2018: is a need to develop fundamen-tally new approaches to enable the simultaneous optimisationof all these traits. ... Recently, new and more quantitative methods based onautomated immune-detection,51 split beta-galactosidase, and splitGFP,52 have been -
Reversible inhibition of the ClpP protease via an N-terminal…
www-vendruscolo.ch.cam.ac.uk/vahidi2018pnas.pdf23 Sep 2018: contributed new reagents/analytic tools; S.V., Z.A.R.,M.B., T.Y., and L.E.K. analyzed data; S.V., Z.A.R., J.L.R., and ... design of new small-molecule modulators have led to efforts to understand the relation-ship among ClpP structure, dynamics, and
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