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  2. MobiDB 3.0: more annotations for intrinsic disorder, conformational…

    www-vendruscolo.ch.cam.ac.uk/piovesan2018nar.pdf
    22 Apr 2018: New curated data. MobiDB 3.0 includes different sources of manually curateddisorder annotations (Table 1). ... 2016) ELM 2016–data update and new functionality of theeukaryotic linear motif resource.
  3. OP-CBIO180177 2944..2950

    www-vendruscolo.ch.cam.ac.uk/liberis2018b.pdf
    23 Sep 2018: tors b are parameters learned by the network. • The new cell state Ct and ht, as well as the output yt is given by:. ... IEEE, Athens, Greece. Xia,X. and Xie,Z. (2002) Protein structure, neighbor effect, and a new index.
  4. Systematic mapping of free energy landscapes of a growing filamin…

    www-vendruscolo.ch.cam.ac.uk/waudby2018pnas.pdf
    27 Sep 2018: On addition of this enzyme,folding of 6 was no longer observed in real-time NMR exper-iments, but instead, new exchange cross-peaks were observedbetween N and U states in
  5. 22 Apr 2018: The secondary nucleation process involves existing fibrils catalysing the nucleation of new aggregates from monomeric pep-tide. ... parameters are related to the rate of formation of new aggregates through primary pathways λ = k k m2 (0)n.
  6. SAR by kinetics for drug discovery in protein misfolding diseases

    www-vendruscolo.ch.cam.ac.uk/chia2018pnas.pdf
    26 Sep 2018: V. contributed new reagents/analytic tools; S.C., J.H., T.C.T.M., S.I.A.C., S.L., C.M.D.,T.P.J.K., and M.V.
  7. 23 Sep 2018: findings provide new insights into the potential. applications of NbSyn87 in diagnostic and therapeu-. ... DG, de Yebenes JG (2004) The new mutation,E46K, of alpha-synuclein causes Parkinson and Lewybody dementia.
  8. 18 Dec 2018: 2Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA. ... 7Division of Integrative Neuroscience, New York State Psychiatric Institute, New York, NY, USA.
  9. Cholesterol catalyses Aβ42 aggregation through a heterogeneous…

    www-vendruscolo.ch.cam.ac.uk/habchi2018nc.pdf
    26 May 2018: In either type of primary nucleation, once a critical number of fibrils is formed, secondary nucleation becomes the major source for generating new oligomers. ... These two combinations define the intrinsic timescales associated with the proliferation of
  10. Third generation antibody discovery methods: in silico rational design

    www-vendruscolo.ch.cam.ac.uk/sormanni2018csr.pdf
    18 Dec 2018: is a need to develop fundamen-tally new approaches to enable the simultaneous optimisationof all these traits. ... Recently, new and more quantitative methods based onautomated immune-detection,51 split beta-galactosidase, and splitGFP,52 have been
  11. Reversible inhibition of the ClpP protease via an N-terminal…

    www-vendruscolo.ch.cam.ac.uk/vahidi2018pnas.pdf
    23 Sep 2018: contributed new reagents/analytic tools; S.V., Z.A.R.,M.B., T.Y., and L.E.K. analyzed data; S.V., Z.A.R., J.L.R., and ... design of new small-molecule modulators have led to efforts to understand the relation-ship among ClpP structure, dynamics, and

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