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16 Jan 2011: Science 1991, 254:1598-1603. 2. Fersht AR: Structure and Mechanism in Protein Science:A Guide to Enzyme Catalysis and Protein Folding New York: W.H.Freeman; 1999. ... Nat Chem Biol 2009, 5:808-814. 47. O’Brien PJ, Herschlag D: Catalytic promiscuity and

7 Apr 2011: rate mtot k+ and the fragmentation ratek have to double for the overall rate of productionof new filaments to double. ... Polymerization of Protein (Academic Press, New York,1975). 21. M. Fändrich, J.

16 Jan 2011: Present address: Department of Biochemistry, Columbia University,New York, NY 10032. J.

4 Feb 2011: Inthese cases, new principles have to be established to. 1 Correspondence: MRC National Institute for MedicalResearch, The Ridgeway, Mill Hill, London NW7 1AA, U.K.E-mail: ... The high ten-dency of Josephin to aggregate even at room tempera-ture forced

16 Jan 2011: H. Freeman, New York, NY. 3. Moult, J., Fidelis, K., Kryshtafovych, A., Rost, B. ... H. Freeman & Co., New York, NY. 41. Meek, J. L.

16 Jan 2011: Lipman D. Gapped BLAST and PSI-BLAST: a new generation of. protein database search programs.

16 Jan 2011: Thus, the production and degradation of new proteins in the. unfolded state can be considered constant and is omitted from.

16 Jan 2011: and physicochemical properties of the various mutant Ab. peptides, and gain new insights into the specific determinants.

16 Jan 2011: 3 online). Wethen used the new ensembles to back-calculate F-values using FoldX.The use of reshuffled F-values generated putative structuresof TS1 and TS2 that differ markedly from those ... 13. Dennis, C.A. et al. A structural comparison of the colicin

16 Jan 2011: such an approach it is possible to provide new insights into the origin and. ... whichwell-established physical and chemical principles can provide new insights into theapparent complexity of biology.27.