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  2. CURRICULUM VITAE

    https://www2.mrc-lmb.cam.ac.uk/groups/bienz/wp-content/uploads/sites/23/BienzCV_March2024.pdf
    11 Apr 2024: signalling. EMBO J 18, 1630-1641. 60. Yu X, Waltzer L & Bienz M (1999) A new Drosophila APC homologue associated with. ... Science 316, 1619-1622. 93. Tran H, Hamada F, Schwarz-Romond T & Bienz M (2008) Trabid, a new positive regulator of.
  3. 3919Commentary Introduction Kinesin motors use energy supplied by ATP …

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/JCScommentary.pdf
    31 Oct 2007: 1) The tethered, ADP-bound lead head is free to find a new binding site. ... N., Muller,J. and Mandelkow, E. (2000). A new look at the microtubule binding patterns ofdimeric kinesins.
  4. doi:10.1016/j.cell.2008.11.004

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/55_Kang_SW_Cell_2008.pdf
    21 Nov 2008: redox perturbations), thereby providing a new tool for exploring the ER. ... This new molecular tool can now be combined with the vast collections of yeast strains (deletion, hypomorphic, overexpression, and other mutations) to reveal previously
  5. LETTERS A bacterial dynamin-like proteinHarry H. Low1 & Jan ...

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/nature%20BDLP%202006.pdf
    28 Nov 2006: S. & Vallee, R. B.Molecular cloning of the microtubule-associated mechanochemical enzymedynamin reveals homology with a new family of GTP-binding proteins.
  6. nature structural biology . volume 5 number 6 . june 1998

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/nsb1998.pdf
    14 Jan 2002: Lloyd, C.W. Microtubules (Wiley-Liss, New York, 1993). 2. 3m. 4C. ... Hol, W.G. Crystal structure of glycosomal glyceraldehyde-3-. phosphate dehydrogenase from Leishmania mexicana: implications for structure-based drug design and new position for the
  7. 7400749.qxd

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/41_Ashok_A_EMBORep_2006.pdf
    19 Jun 2006: Intriguing new studiesindicate a potentially key role for MVB pathways in prion transmis-sion and metabolism, reinforcing the central importance of proteintransport pathways as the molecular basis of various diseases. ... Validation of thisprovocative
  8. 73687_Trans

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/emboj201099s2.pdf
    28 Apr 2010: There are still questions about how the structure recognizes the very slight curvature of the polar membrane, but the new structural information greatly advances the discussion.
  9. Jason William Chin Page 1 of 18 MRC Laboratory ...

    https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-content/uploads/2024/01/Chin-cv-26012024.pdf
    29 Jan 2024: 2008. 4: 232-234. [Featured in Nature 2008. 45: 868, Chemistry & Engineering News (ACS). ... 2006. 2: 254-258. [News & Views, Nature Chem. Biol. 2006. 2: 231-232].
  10. Crystal Screen Lite™ is a complete reagent kit designed ...

    https://www2.mrc-lmb.cam.ac.uk/screens2/pdf/LMB06b.pdf
    26 Jun 2015: Discard the pipet tip, add a new pipet tip and pipet 1 ml of Crystal Screen Lite reagent 2 into reservoir A2.
  11. MinCD cell division proteins form alternating copolymeric cytomotive…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/ncomms6341.pdf
    6 Dec 2014: analyses, we show that MinD activates MinC by forming a new class of alternating. ... We combined our new crystalstructure with the EcMinD dimer structure, revealing twointeresting features (Fig.
  12. rq5005

    https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/iucrjS20.pdf
    28 Jul 2020: L. D. & Kirshner, D. A. (1971). Nature New Biol. 231,.
  13. The current approach to initial crystallization screening of proteins …

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Gorrec_undersamplid_2013.pdf
    14 May 2013: structure determination and explains why the development of more. efficient crystallization screens is still challenging (McPherson &. Cudney, 2006). We are constantly testing new conditions and will. eventually integrate them into our
  14. M410_8e 231..235

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Dynamin.pdf
    6 Mar 2001: single site that denes a new SH3 binding consensus sequence. J. ... Medicine, Oxford University, Roosevelt Drive, Oxford OX3 7BN, UK. The Oxford Centre for Molecular Sciences, New Chemistry, South Parks Road,Oxford OX1 3QT, UK These authors contributed
  15. pnas201313978 4601..4610

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/pnas2013duman.pdf
    23 Dec 2013: The G109K substitution has a dramatic ef-fect, because in the new crystals the protein filaments are absent,but dimers are still present (Fig. ... Construction of Plasmids for Protein Purification. pMal-C2X (New EnglandBiolabs) was used to clone and
  16. 1 Supplementary data to accompany paper: Mechanism of endophilin ...

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/GallopEndophilinEMBO/EndoSupMethods.pdf
    8 Jun 2006: oxyl-2,2,5,5-tetramethylpyrroline-3-methyl]-methanethiosulfonate) to generate the new side. chain R1 using a previously described protocol (Jao et al., 2004).
  17. se060101051p

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/ford01.pdf
    3 Dec 2004: 17,4943 (1998). 35. A. G. W. Leslie, in Joint CCP4 and ESF-EACMB News-letter on Protein Crystallography No.
  18. se289900215p

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/strucrev.pdf
    6 Jul 1999: icle membrane or cellular responses to envi-ronmental stimuli. The developments seenover the past couple of years will continue;new insights and structures will be publishedsoon. ... The challenge for the new century willbe to understand how these
  19. 53091 361..366

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/McMahon01020.pdf
    3 Dec 2004: Theformation of a new vesicle is thought to be driven by both thepolymerization of the coat protein clathrin into a cage-like structureand the selection/modification of membrane lipids5,6. ... solved in the absence of a lipid head group14 (Fig. 2a,
  20. Cryo-EM reconstruction of AlfA from Bacillus subtilis reveals the…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/AlfA2018.pdf
    20 Mar 2018: The antiparallel orientation of the. filaments is necessary to ensure that when new protomers areadded to the spindle, it grows in opposite directions and pushes theplasmid copies apart (23). ... FASEB J 9:167–174.36. Krissinel E, Henrick K (2004)
  21. PII: S0166-2236(03)00131-0

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/25_Hegde_RS_TINS_2003.pdf
    30 Jun 2003: Clearly, establishingany relationship between PrPSc and cyPrP represents aformidable challenge and will necessitate the developmentof new tools to readily detect and modulate cyPrPformation in precise and selective ways.
  22. 2077 741..748

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/21_Lingappa_VR_BioEssays_2002.pdf
    5 Jul 2002: Furthermore, new. Table 1. Organizing principles for the levels of complexity in protein folding. ... A new varia-. tion on the translocation of proteins occurs during the early biogenesis of.
  23. The life of proteins: the good, the mostly good and the ugly

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/68_Morimoto_RI_NSMB_2011.pdf
    7 Jan 2011: Several new concepts and methods are bringing nascent-chain biology to the forefront of the field. ... Nascency and nascent-chain biologyReplenishment and renewal of the ‘protein community’ of cellular proteins requires new proteins to be synthesized.
  24. Cover MRC Case Studies FAW09

    https://www2.mrc-lmb.cam.ac.uk/archive/articles/Reviewing_translation_at_the_MRC.pdf
    15 Apr 2015: MRC science needs to be effectively translated into powerful new therapies, diagnostics, devices, and research tools. ... then for investigating other potential protein modifications. The technology will help produce new protein reagents that.
  25. mk069902063p

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Fitting.MBC.pdf
    26 May 1999: We present a new map showing dimeric kinesin bound to microtubules in the presenceof ADP that was obtained by electron cryomicroscopy and image reconstruction. ... Interactions with TubulinMonomeric kinesin is represented in Figure 9 as aspace-filling
  26. st7a11.qxd

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/MukB%20Structure%201999.pdf
    10 Sep 1999: Yale University Press, New Haven, CT. 31. Engh, R.A. & Huber, R. ... Columbia University, New York. Research Article MukB crystal structure van den Ent et al.
  27. The Jour nal o f Cel l Bio logy ...

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/epsinR.pdf
    9 Jan 2003: synergin and useto predict that an uncharacterized EF-hand–containingprotein will be a new gamma binding partner. ... We have proposed that on binding to membranes,this new helix buries itself between the lipid headgroups,pushing the lipids apart and
  28. Changes in Postural Syntax Characterize Sensory Modulation and…

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-5.pdf
    14 Aug 2015: New imaging technology has made it possible to record neural activity from the majority ofC. ... 2. Lehner PN. Handbook of ethological methods. 2nd ed. Cambridge ; New York: Cambridge UniversityPress; 1996.
  29. DOI: 10.1126/science.1184429 , 1638 (2010); 327Science et al.Simon…

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/20339072.pdf
    2 Aug 2010: The title. CopyrightAmerican Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. ... This can becrucial in the design of new generations of Vps34inhibitors with improved specificity, solubility,and cellular
  30. Activation of Xer-recombination at dif: structural basis of the…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/srep33357.pdf
    30 Sep 2016: New Biol 3, 799–811 (1991). 7. Carnoy, C. & Roten, C. ... J. & Donachie, W. D. A new Escherichia coli cell division gene, ftsK.
  31. No Job Name

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/MreC%20MM%202006.pdf
    7 Dec 2006: 2005) A high-throughput structuralbiology/proteomics beamline at the SRS on a new multi-pole wiggler. ... New York, NY:Academic Press, pp. 472–494. Defeu Soufo, H.J., and Graumann, P.L.
  32. Model-Building with Coot Paul EmsleyUniversity of Oxford June 2011 ...

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/aca-2012-low-resolution-scripting-ligands-and-bumps.pdf
    28 Jul 2012: Overview of Presentation: New algorithms and features Tips on Usage Focus on:. ... Hydrogen tunnelling. Alpha Helix Placement Scenario: Looking at a new map, not built with.
  33. se289900215p

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/research/strucrev.pdf
    6 Jul 1999: icle membrane or cellular responses to envi-ronmental stimuli. The developments seenover the past couple of years will continue;new insights and structures will be publishedsoon. ... The challenge for the new century willbe to understand how these
  34. S413_6a 39..44

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/MreB%20Nature.pdf
    30 Aug 2001: 35. BruÈ nger, A. T. et al. Crystallography & NMR system: a new software suite for macromolecular.
  35. se060101051p

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/epsin/EM/ford.pdf
    3 Dec 2004: 17,4943 (1998). 35. A. G. W. Leslie, in Joint CCP4 and ESF-EACMB News-letter on Protein Crystallography No.
  36. doi:10.1016/j.molcel.2006.07.020

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/HiroseMC2006.pdf
    8 Sep 2006: The new crystal structures are thought to resemblemyosin bound to an actin filament in the rigor state. ... domains binding to new sites on the MT. turn can affect the conformation of switch I and the nu-cleotide binding pocket near switch I.
  37. doi:10.1016/j.cub.2004.07.058

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/15296756.pdf
    6 Oct 2004: 2001). Rap1 signal-ling: adhering to new models. Nat. Rev. Mol. Cell Biol.
  38. Phil. Trans. Roy. Soc. Lond. B. 261, 95-104 (1971) ...

    https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/ptrs71.pdf
    26 Nov 2012: 1964 Fundamentals riftransmission electron microscopy. New York: Interscience. Heidenreich, R. D. &
  39. TBS may template.qxd

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/epsin/EM/mcmahon.pdf
    3 May 2002: J. Biol. Chem. 275, 38597–38604. 33 Darrouzet, E. et al. (2001) Large scale domainmovement in cytochrome bc1: a new device forelectron transfer in proteins.
  40. doi:10.1016/j.pbiomolbio.2004.07.009

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/stock2005robot.pdf
    19 Jan 2005: authors. Thesedevelopments along with advances in structure determination techniques (mainly the use ofsynchrotrons, area detectors and crystal freezing) led to an enormous increase in new proteinstructures: in 1990, about 500 structures
  41. mbar-v2

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/tutorial/model-building-and-refinement-v2.pdf
    31 Aug 2018: proceed. 2.2.3.The new waters have been added to chain D, and it is important to inspect them and make sure that they have all been added in appropriate
  42. Bb9e55.qxd

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Vallis_McMahon1999.pdf
    21 Mar 2003: of dynamin at a single site that defines a new SH3binding consensus sequence.
  43. Dynamin-dependent and dynamin-independentprocesses contribute to the…

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Graham02.pdf
    29 Apr 2002: a new mean half-width.
  44. DOI: 10.1126/science.1256917, 963 (2014);346 Science et al.Thomas G.…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Science-2014-Gligoris-963-7.pdf
    21 Nov 2014: The title. CopyrightAmerican Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. ... Cross-linking cohesin containing cysteinesat all three interfaces generated a new formform (Ci) whose electrophoretic mobility
  45. Calcium-mediated Evidence from the Changes in Gap Junction Low ...

    https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/jcb83.pdf
    1 Nov 2012: St. Louis, MO); sodium deoxycholate from Calbiochem-Behring Corp. (La Jolla, CA); and HLlabeled sodium deoxycholate (4 Ci/mmol) from New England Nuclear (Boston, MA).
  46. se060101047p

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Itoh%20et%20al.pdf
    23 Nov 2004: X-ray Crystallography and NMR (Yale Univ. Press,New Haven, CT, 1993). 24.
  47. pone.0107211 1..10

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/leoa2014.pdf
    3 Sep 2014: LeoA, B and C from Enterotoxigenic Escherichia coli(ETEC) Are Bacterial DynaminsKatharine A. Michie1.¤a, Anders Boysen2., Harry H. Low1.¤b, Jakob Møller-Jensen2, Jan Löwe1. 1 MRC Laboratory of Molecular Biology, Structural Studies Division,
  48. Biol. Chem., Vol. 381, pp. 993 – 999, September/October ...

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/BiolChem%20Helical%20Tubes.pdf
    13 Sep 2000: Biol. Chem., Vol. 381, pp. 993 – 999, September/October 2000 Copyright by Walter de Gruyter Berlin New York.
  49. Bacterial actin MreB assembles in complex with cell shape protein RodZ

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/embo2010RodZMreB.pdf
    17 Feb 2010: References. Adams PD, Grosse-Kunstleve RW, Hung LW, Ioerger TR, McCoy AJ,Moriarty NW, Read RJ, Sacchettini JC, Sauter NK, Terwilliger TC(2002) PHENIX: building new software for automated crystal-lographic ... Mol Microbiol 51:1321–1332. Gerdes K (2009)
  50. Contrasting Membrane Interaction Mechanisms of AP180N-terminal…

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Stahelin_cho2003.pdf
    16 Jul 2003: the Department ofMicrobiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, andthe Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of ... Karol Bruzik.Phospholipid
  51. PII: 0896-6273(89)90235-3

    https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/neuron89.pdf
    11 Sep 2003: New channel proteins are being discovered and characterized, Superfamilies of voltage- and ligand-gated channels are being identified and ex- tended. ... without the energetically unfavored pro- cesses of creating substantial new surfaces or invoking

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