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Complete fly brain images at nanoscale resolution - MRC Laboratory of …
https://www2.mrc-lmb.cam.ac.uk/complete-fly-brain-images-at-nanoscale-resolution/30 Jul 2018: A neuroscience milestone: a high-resolution digital snapshot of the adult fruit fly brain. Researchers can now trace the path of any one neuron to any -
Regulation of DNA replication during early embryogenesis - MRC…
https://www2.mrc-lmb.cam.ac.uk/regulation-of-dna-replication-during-early-embryogenesis/9 Mar 2018: Published on. 9 March, 2018. Julian Sale from the LMB’s PNAC Division and collaborators from the Francis Crick Institute and the Department of Zoology have discovered and characterised a new -
Uncovering the structure of the serotonin receptor - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/uncovering-the-structure-of-the-serotonin-receptor/21 Jun 2018: Understanding the activation mechanism of the serotonin receptor and the mode of binding of a failed anti-migraine drug, donitripan, will hopefully aid the development of new and improved drugs. ... Comparing the new G. o. -receptor structure to other -
‘Mini-brains’: understanding brain growth and disease - MRC…
https://www2.mrc-lmb.cam.ac.uk/mini-brains-understanding-brain-growth-and-disease/30 Apr 2018: Philip Ball, science writer at The Guardian, has had a ‘mini-brain’ grown from a sample of skin from his arm. He talks to the LMB’s Madeline Lancaster, -
Decades of discovery set to revolutionise healthcare - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/decades-of-discovery-set-to-revolutionise-healthcare/1 Nov 2018: A summary of key milestones that show how discovery science has been translated into a novel technology set to revolutionise healthcare. The milestones -
Tau filament structures differ between neurodegenerative diseases -…
https://www2.mrc-lmb.cam.ac.uk/tau-filament-structures-differ-between-neurodegenerative-diseases/30 Aug 2018: These new structures show how tau folds in disease-specific ways, providing evidence for the hypothesis that different molecular structures of filamentous tau give rise to the diversity of symptoms between ... Comparison of the new structures of -
Melina Schuh writes about the turning point in her career: becoming a …
https://www2.mrc-lmb.cam.ac.uk/melina-schuh-writes-about-turning-point-in-career/31 Aug 2018: Melina Schuh, a former group leader in the LMB’s Cell Biology Division, has written about her experiences setting up her group at the LMB while also -
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/acedrg-link…
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/acedrg-link-usage-notes.txt14 Mar 2018: Evaluating the script in Coot will provide a new menu item "Acedrg" Clicking on "Make Link with Link Dictionary from Acedrg" will create a new small dialog The bond order can -
Richard Henderson is guest on BBC Radio 4, 'The Life…
https://www2.mrc-lmb.cam.ac.uk/richard-henderson-guest-bbc-radio-4-life-scientific/13 Feb 2018: Richard Henderson talks to Jim Al-Khalili about his childhood, studies and career, specifically his journey working on the development of cryo-electron -
Melina Schuh awarded Biochemical Society Colworth Medal - MRC…
https://www2.mrc-lmb.cam.ac.uk/melina-schuh-awarded-biochemical-society-colworth-medal/23 Apr 2018: Melina Schuh has been awarded the Biochemical Society 2019 Colworth medal. Melina investigates how chromosome segregation errors arise during the meiotic -
Rebecca Taylor discusses aging on BBC Radio Cambridgeshire - MRC…
https://www2.mrc-lmb.cam.ac.uk/rebecca-taylor-discusses-aging-bbc-radio-cambridgeshire/22 Feb 2018: As part of a programme about aging, Rebecca Taylor from the LMB’s Neurobiology Division, talks to presenter Chris Mann about the science behind why we -
Magdalena Skipper appointed editor-in-chief at Nature - MRC…
https://www2.mrc-lmb.cam.ac.uk/magdalena-skipper-appointed-editor-in-chief-at-nature/3 May 2018: Magdalena Skipper has been appointed editor-in-chief at Nature, becoming the first woman to hold the role in its almost 150-year history. More... -
How the earliest life on Earth may have replicated itself - MRC…
https://www2.mrc-lmb.cam.ac.uk/how-the-earliest-life-on-earth-may-have-replicated-itself/16 May 2018: He then engineered the best version to be able to copy pieces of itself, and assemble them together into new full synthetic copies. ... This new synthetic biology of triplet based RNA replication might also have biotechnological applications, such as -
2018 Francis Crick Lecture to be given by Gero Miesenböck - MRC…
https://www2.mrc-lmb.cam.ac.uk/2018-francis-crick-lecture-to-be-given-by-gero-miesenbock/17 Oct 2018: In 2002, Gero established the principles of optogenetic control and thereby defined a new, now widely used, approach for probing the function of the nervous system. ... Gero studied medicine at the University of Innsbruck in his native Austria and did -
John Kendrew Lecture to be given by Jacques Dubochet - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/john-kendrew-lecture-to-be-given-by-jacques-dubochet/19 Apr 2018: Jacques Dubochet will give the 2018 John Kendrew Lecture on Thursday 26th April at 4.00pm in the LMB’s Max Perutz Lecture Theatre. The title of the -
Understanding how TRIM21 is regulated during viral infection - MRC…
https://www2.mrc-lmb.cam.ac.uk/understanding-how-trim21-is-regulated-during-viral-infection/19 Apr 2018: New work from Leo James’ group in the LMB’s PNAC Division has now revealed how TRIM21 is regulated so that it is only switched on at the right time. ... In addition, Leo’s lab has recently developed a new technique, ‘TrimAway’, which uses -
The legacy of Fred Sanger - 100 years on from 1918 - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/the-legacy-of-fred-sanger-100-years-on-from-1918/31 May 2018: This August marks the centenary of the birth of Fred Sanger, LMB alumnus and one of the most influential scientists of the twentieth century. By devising -
Science Weekly podcast: Growing mini-brains in the lab - MRC…
https://www2.mrc-lmb.cam.ac.uk/science-weekly-podcast-growing-mini-brains-in-the-lab/14 May 2018: In this week’s science podcast from The Guardian, Madeline Lancaster is interviewed to find out about the mini human brains that she and her group are -
Uncovering how alcohol-derived metabolites damage the genome of stem…
https://www2.mrc-lmb.cam.ac.uk/uncovering-alcohol-derived-metabolites-damage-genome-stem-cells/4 Jan 2018: This new research has several implications for human health. It provides a simple explanation for how alcohol, which is a source of acetaldehyde, causes genetic damage and therefore acts as a ... In addition, the new insight into the function of p53 in -
Daniel McGillivray Brown. 3 February 1923-24 April 2012 - MRC…
https://www2.mrc-lmb.cam.ac.uk/daniel-mcgillivray-brown-3-february-1923-24-april-2012/21 Nov 2018: Dan Brown was a nucleic acids chemist of the highest order, beginning with pioneering work under Lord Alexander Todd in the 1950s at University of -
John Kendrew Lecture to be given by Xiaowei Zhuang - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/john-kendrew-lecture-to-be-given-by-xiaowei-zhuang/5 Jan 2018: Xiaowei Zhuang will give the 2017 John Kendrew Lecture on Monday 15th January 2018 at 4.00pm in the LMB’s Max Perutz Lecture Theatre. The title of the -
Minutes of the CCP4 Ligands Meeting March 2018
https://www2.mrc-lmb.cam.ac.uk/coot/ligands/minutes-ccp4-ligands-meeting-march-2018.html23 Mar 2018: Briefly mentioned Coot's new N-linked carbohydrate builder. Note: we are using latest CCP4 expert version. ... But new users will be confused. AP: PE to investigate making some videos. -
Cambridge LIFE LAB project wins place in Europe’s largest public…
https://www2.mrc-lmb.cam.ac.uk/cambridge-life-lab-project-wins-place-in-europes-largest-public-science-event/11 Jun 2018: LIFE LAB events are for everyone – we hope to meet and connect with many new people.”. -
Luca Jovine and Leonid Sazanov elected to EMBO membership - MRC…
https://www2.mrc-lmb.cam.ac.uk/luca-jovine-and-leonid-sazanov-elected-to-embo-membership/18 May 2018: LMB alumni Luca Jovine and Leonid Sazanov have been newly elected as members of the European Molecular Biology Organisation (EMBO), on the basis of their -
The legacy of Fred Sanger - 100 years on from 1918 - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/the-legacy-of-fred-sanger-100-years-on-from-1918-2/14 Aug 2018: August 2018 marks the centenary of the birth of Frederick (Fred) Sanger (1918–2013), one of the most influential scientists of the 20th century. Few -
Melina Schuh awarded a 2019 Gottfried Wilhelm Leibniz Prize - MRC…
https://www2.mrc-lmb.cam.ac.uk/melina-schuh-awarded-a-2019-gottfried-wilhelm-leibniz-prize/17 Dec 2018: The latest recipients of Germany’s most prestigious research prize, the Gottfried Wilhelm Leibniz Prize have been announced, and includes former LMB group -
Controlling actin polymerisation in clathrin mediated endocytosis -…
https://www2.mrc-lmb.cam.ac.uk/controlling-actin-polymerisation-in-clathrin-mediated-endocytosis/7 Jun 2018: The molecular details elucidated by this new research may open avenues to develop drugs to fight infections and to design complementary therapeutic strategies for some types of cancers. -
Reversing a decline in cellular transport in ageing nerve cells - MRC …
https://www2.mrc-lmb.cam.ac.uk/reversing-a-decline-in-cellular-transport-in-ageing-nerve-cells/29 Mar 2018: This work opens new avenues for attempting to manipulate transport in a therapeutic setting. -
How cells selectively enhance gene expression in response to stress - …
https://www2.mrc-lmb.cam.ac.uk/how-cells-selectively-enhance-gene-expression-in-response-to-stress/5 Sep 2018: In order to make new proteins, genes are first transcribed to produce messenger RNA (mRNA) molecules, that are then translated into proteins. ... This means that this new role for tRNAs in the control of gene expression could have a role in human disease. -
Bill Schafer elected Fellow of the Academy of Medical Sciences - MRC…
https://www2.mrc-lmb.cam.ac.uk/bill-schafer-elected-fellow-of-the-academy-of-medical-sciences/10 May 2018: Bill Schafer, group leader in the LMB’s Neurobiology Division, has been elected into the Fellowship of the Academy of Medical Sciences. The Academy -
Michel Goedert: on our best hope for tackling Alzheimer's disease …
https://www2.mrc-lmb.cam.ac.uk/michel-goedert-our-best-hope-for-tackling-alzheimers-disease/26 Mar 2018: Michel Goedert, winner of Brain Prize 2018, believes our best hope of fighting Alzheimer's disease lies in learning to predict who will get it and -
LMB student and postdoc prizes awarded to exceptional scientists -…
https://www2.mrc-lmb.cam.ac.uk/lmb-student-and-postdoc-prizes-awarded-to-exceptional-scientists/17 Oct 2018: After being involved in the discovery of phospho-ubiquitin and its new conformational switch, Christina deciphered the molecular mechanism of parkin activation by phospho-ubiquitin, that parkin phosphorylation is important and -
The epic hunt for the place on Earth where life started - MRC…
https://www2.mrc-lmb.cam.ac.uk/the-epic-hunt-for-the-place-on-earth-where-life-started/21 Jun 2018: Working out how and where life began is one of the greatest puzzles to solve. The LMB’s Philipp Holliger and John Sutherland, and others, discuss their -
Wanda Kukulski awarded the Royal Microscopical Society’s Alan Agar…
https://www2.mrc-lmb.cam.ac.uk/wanda-kukulski-awarded-the-royal-microscopical-societys-alan-agar-medal/31 Aug 2018: Wanda Kukulski, group leader in the LMB’s Cell Biology Division, has been awarded the Royal Microscopical Society’s Alan Agar Medal for Electron -
CootCryoEMPractical-v2.md
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/CootCryoEMPractical-v2.md.html15 Aug 2018: Chain-refine (Shift E). We still have the wrong sequence, let’s apply the new one:. -
Sarah Teichmann awarded the Genetics Society's 2018 Mary Lyon…
https://www2.mrc-lmb.cam.ac.uk/sarah-teichmann-awarded-genetics-societys-2018-mary-lyon-medal/31 Jan 2018: Sarah Teichamnn has received the Genetics Society’s prestigious Mary Lyon Medal 2018 for “outstanding research” in understanding how the immune system -
Dr Varodom Charoensawan wins the 2018 FAOBMB Young Scientist Award -…
https://www2.mrc-lmb.cam.ac.uk/dr-varodom-charoensawan-wins-2018-faobmb-young-scientist-award/2 Feb 2018: Dr Varodom Charoensawan, former PhD student in the LMB’s Structural Studies Division, has been awarded the FAOBMB Young Scientist Award for his work on -
Three-dimensional representation of motor space in the brain - MRC…
https://www2.mrc-lmb.cam.ac.uk/three-dimensional-representation-of-motor-space-in-the-brain/17 May 2018: These results provide the first evidence of a three-dimensional representation of motor space in the superior colliculus and give new insights into the mechanisms underlying the control of spatially-targeted -
A parliamentary lab meeting - Daniel Zeichner MP visits the LMB - MRC …
https://www2.mrc-lmb.cam.ac.uk/a-parliamentary-lab-meeting-daniel-zeichner-mp-visits-the-lmb/14 Jun 2018: Glenn Masson, postdoc in the LMB’s PNAC Division, took part in this year’s Royal Society Parliamentary Pairing Scheme. Read Glenn’s blog to find out more -
Susan Shao and Tanmay Bharat appointed as 2018 Vallee Scholars - MRC…
https://www2.mrc-lmb.cam.ac.uk/susan-shao-and-tanmay-bharat-appointed-as-2018-vallee-scholars/3 Oct 2018: LMB alumni Susan Shao and Tanmay Bharat are two of the five scientists to be awarded prestigious Vallee Scholarships in 2018. The Vallee Scholars program -
LMB’s Challenge Project with Cambridge Academy for Science and…
https://www2.mrc-lmb.cam.ac.uk/lmbs-challenge-project-with-cambridge-academy-for-science-and-technology/23 Mar 2018: Theo, one of the students who participated in the Challenge Project, said the project “opened up new career ideas and broadened my horizons”. -
Silent tuberculosis is less common than had been widely thought - MRC …
https://www2.mrc-lmb.cam.ac.uk/silent-tuberculosis-is-less-common-than-had-been-widely-thought/24 Sep 2018: A study by Lalita Ramakrishnan, from the University of Cambridge Molecular Immunity Unit based in the LMB, has found that most people who fall seriously -
The winner of the 2018 LMB’s schools Science Image Award is… - MRC…
https://www2.mrc-lmb.cam.ac.uk/the-winner-of-the-2018-lmbs-schools-science-image-award-is/13 Jul 2018: Thirteen primary schools from Cambridge and the surrounding area have participated in this year’s Science Image Award. The competition, part of the LMB’s -
Ana Casañal awarded Biochemical Society Early Career Research Award.…
https://www2.mrc-lmb.cam.ac.uk/ana-casanal-awarded-biochemical-society-early-career-research-award/4 Apr 2018: Ana Casañal from the LMB’s Structural Studies Division has been awarded the prestigious Biochemical Society Early Career Research Award 2019 for Genes. -
REFMAC5 Tutorial - Part 2
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/tutorials/refmac_tutorial/files/part_2.html23 Jun 2018: Show Me This. A new job will be created. The main inputs may already be populated with data from a previous job, in which case select "No" from the "Use data ... This will create a new job, pre-populated with the inputs from the previous job. -
LMB showcases the diversity of science at the Cambridge Science…
https://www2.mrc-lmb.cam.ac.uk/lmb-showcases-the-diversity-of-science-at-the-cambridge-science-festival/28 Mar 2018: New for the 2018 Guildhall event, members of the public could pop into the special science booth to chat to the scientists about their research. ... His talk looked at the exciting work in the field of structural biology, tracing the beginnings of the -
Johannes Kohl wins the 2018 Eppendorf & Science Prize for…
https://www2.mrc-lmb.cam.ac.uk/johannes-kohl-wins-the-2018-eppendorf-science-prize-for-neurobiology/17 Oct 2018: Johannes Kohl, a former PhD student from Greg Jefferis’ group in the LMB’s Neurobiology division, is the grand prize winner in The Eppendorf & Science -
From Backbench to Lab Bench: LMB welcomes visitors from Westminster - …
https://www2.mrc-lmb.cam.ac.uk/from-backbench-to-lab-bench-lmb-welcomes-visitors-from-westminster/17 Apr 2018: Daniel Zeichner MP for Cambridge, and Nancy Bailey and Rebecca Nohl from the Government Office for Science, swapped policy and debate for lab coats and -
Alcohol can cause irreversible genetic damage to stem cells, says…
https://www2.mrc-lmb.cam.ac.uk/alcohol-can-cause-irreversible-genetic-damage-stem-cells-says-study/5 Jan 2018: Link between drinking and cancer clarified by study - led by KJ Patel’s group in the LMB’s PNAC Division - which indicates alcohol causes cancer by -
Making the undruggable druggable: the first platform to discover…
https://www2.mrc-lmb.cam.ac.uk/making-the-undruggable-druggable-the-first-platform-to-discover-selective-phosphatase-inhibitors/26 Jul 2018: New method identifies a selective inhibitor of PPP1R15B, a potential target for Huntington’s disease. ... This novel approach may pave the way to a new therapeutic strategy for such diseases.
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