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LMB scientists creating fun and fascination at the Cambridge Science…
https://www2.mrc-lmb.cam.ac.uk/lmb-scientists-creating-fun-fascination-cambridge-science-festival/30 Mar 2017: Brad’s talk ‘Life through a Lens’ showed spectacular new 3D images, made possible due to his development of the Mesolens.
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Tau filaments from the Alzheimer's brain revealed - MRC…
https://www2.mrc-lmb.cam.ac.uk/tau-filaments-alzheimers-brain-revealed/17 Jul 2017: Tau filaments isolated from an Alzheimer’s brain are the latest, high-profile exploit of cryo-electron microscopy. Crafting a technique that has become
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Cell scientist to watch – Madeline Lancaster - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/cell-scientist-watch-madeline-lancaster/4 Jan 2017: Madeline Lancaster, group leader in the LMB’s Cell Biology Division, is interviewed by the Journal of Cell Science and describes her impetus to pursue a
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Manu Hegde receives Feldberg Foundation Prize - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/manu-hegde-receives-feldberg-foundation-prize/9 Jan 2017: This prompted his group to investigate how mis-localised proteins are recognised and degraded, leading to their discovery of new protein quality control pathways.
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Reprogramming gene expression with small molecules - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/reprogramming-gene-expression-small-molecules/31 Jul 2017: New work by Julian Sale’s group in the LMB’s PNAC Division, in collaboration with Shankar Balasubramanian’s group in the University of Cambridge Department of Chemistry, has shown that ... This work suggests a new approach for epigenetic therapy,
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Integral component of the Wnt enhancesome identified - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/integral-component-wnt-enhancesome-identified/16 Mar 2017: In order to probe the composition of the enhancesome, Moore (Laurens M.) van Tienen, from Mariann’s group, applied a relatively new technique called BioID proximity labelling, in order to define ... It could open up new avenues for therapeutic
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Fundamental rules for how the brain controls movements - MRC…
https://www2.mrc-lmb.cam.ac.uk/fundamental-rules-brain-controls-movements/24 Oct 2017: Using the nematode as one test system, scientists at CCNR have spent the past several years understanding how a network controls itself—for instance,
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LMB alumni return to share their career experiences - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/lmb-alumni-return-share-career-experiences/31 Jul 2017: When presented with several new opportunities, Elizabeth followed her heart and is now the Director of Talking Medicines, which enables her to bring together all the skills she has gained. ... Enjoy the challenge of new things, but also enjoy the plateau
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2017 Francis Crick Lecture to be given by Jack Szostak - MRC…
https://www2.mrc-lmb.cam.ac.uk/2017-francis-crick-lecture-given-jack-szostak/21 Aug 2017: In 1984 Jack moved his lab to the Department of Molecular Biology at the Massachusetts General Hospital where his work began to take on a new direction – the study of ribozymes. ... Mechanistic and structural studies have led to new chemical
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International young, budding scientists visit the LMB - MRC…
https://www2.mrc-lmb.cam.ac.uk/international-young-budding-scientists-visit-lmb/9 Aug 2017: The LMB recently hosted eighteen students from the London International Youth Science Forum (LIYSF) for a morning of activities, talks and tours. The
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2017 Milstein Lecture to be given by Thomas Südhof - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/2017-milstein-lecture-given-thomas-sudhof/30 Jan 2017: Professor Thomas Südhof will give the 2017 Milstein Lecture on Thursday 9th February 2017 at 4pm in the LMB’s Max Perutz Lecture Theatre. The lecture,
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LMB welcomes over 2000 visitors to a fun-packed Open Day - MRC…
https://www2.mrc-lmb.cam.ac.uk/lmb-welcomes-2000-visitors-fun-packed-open-day/28 Jun 2017: We were so pleased to be able to share our research into asthma and parasites, and explain to people how our exploration of the immune system can help to develop new ... their structure solved, and found out how this new technique is revolutionising
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Electron cryo-microscopy wins chemistry Nobel - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/cryo-electron-microscopy-wins-chemistry-nobel/6 Oct 2017: Jacques Dubochet, Joachim Frank and Richard Henderson were awarded the prize on 4 October for their work in developing electron cryo-microscopy (cryo-EM),
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Uncovering the action of a selective holophosphatase inhibitor - MRC…
https://www2.mrc-lmb.cam.ac.uk/uncovering-action-selective-holophosphatase-inhibitor/31 Jul 2017: When given to mice, Sephin1 prevents two protein misfolding diseases. New work by the group has now uncovered the mechanism underlying this inhibition, opening up the possibility to target other holophosphatases ... Finally, swapping the N- and
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Soul of a Molecular Machine: A Conversation with Venki Ramakrishnan - …
https://www2.mrc-lmb.cam.ac.uk/soul-molecular-machine-conversation-venki-ramakrishnan/4 May 2017: 4 May, 2017. Conversation with Venki Ramakrishnan: “We’re at the threshold of a new age of structural biology, where these things that everybody thought were too difficult and would take
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Richard Henderson wins 2017 Nobel Prize for Chemistry - MRC…
https://www2.mrc-lmb.cam.ac.uk/richard-henderson-wins-2017-nobel-prize-chemistry/4 Oct 2017: The new structures provide important insights into the biological function of the assemblies and, by catalysing the subsequent development of new diagnostic or therapeutic tools, should help to improve the health
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The UK’s dementia research landscape: LMB is a piece of the jigsaw -…
https://www2.mrc-lmb.cam.ac.uk/uks-dementia-research-landscape-lmb-piece-jigsaw/20 Sep 2017: A new picture, developed by the Medical Research Council (MRC) and National Institute for Health Research (NIHR), illustrates how the jigsaw pieces fit together. ... new insights into prevention.
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Sharp focus on Alzheimer's may help target drugs - MRC Laboratory …
https://www2.mrc-lmb.cam.ac.uk/sharp-focus-alzheimers-may-help-target-drugs/7 Jul 2017: Abnormal deposits that build up in the brain during Alzheimer's have been pictured in unprecedented detail in research led by Sjors Scheres and Michel
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Distinct human mutations can alter the effect of medicine - MRC…
https://www2.mrc-lmb.cam.ac.uk/distinct-human-mutations-can-alter-effect-medicine/19 Dec 2017: An estimated 3 percent of the population have receptors of this type that are so genetically different that they are predisposed to altered, ineffective or adverse responses to medicine, a new
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Genome pioneer John Sulston enters elite club - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/genome-pioneer-john-sulston-enters-elite-club/19 Jun 2017: British genome pioneer Sir John Sulston has been elevated to the Companion of Honour in the Queen’s birthday list. Only 65 people, including the
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Three LMB scientists elected Fellows of the Royal Society - MRC…
https://www2.mrc-lmb.cam.ac.uk/three-lmb-scientists-elected-fellows-royal-society/5 May 2017: It seeks to promote excellence in science, electing up to 52 new Fellows and up to 10 new Foreign Members each year who have made substantial contributions to the improvement of ... This work has led to the discovery of a new immune cell, called a nuocyte
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Exploring the incredible transport system inside our cells - MRC…
https://www2.mrc-lmb.cam.ac.uk/exploring-incredible-transport-system-inside-cells/13 Jul 2017: Simon Bullock discusses his research into intracellular trafficking of RNA, and talks about the importance of science outreach in inspiring the next
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The missing link between golgins and endosomal vesicles discovered -…
https://www2.mrc-lmb.cam.ac.uk/missing-link-golgins-endosomal-vesicles-discovered/30 Oct 2017: New work by Sean’s group has now revealed the missing link that connects endosome-to-Golgi transport vesicles to the golgin tethers.
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LMB bake sale raises funds for ACT Breast Cancer Appeal - MRC…
https://www2.mrc-lmb.cam.ac.uk/lmb-bake-sale-raises-funds-act-breast-cancer-appeal/14 Dec 2017: Since it began in 2004, funds raised by the ACT Breast Cancer Appeal have been used to provide new specialist technologies to aid and expedite diagnosis and treatment in the Cambridge
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Julian Gough discusses the wonders of the SUPERFAMILY database - MRC…
https://www2.mrc-lmb.cam.ac.uk/julian-gough-discusses-wonders-superfamily-database/13 Mar 2017: Julian Gough is interviewed by the Huffington Post and discusses SUPERFAMILY, his database of structural and functional annotations for proteins and
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LMB alumnus, Jonathan Hodgkin, wins Novitski Prize - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/lmb-alumnus-jonathan-hodgkin-wins-novitski-prize/28 Mar 2017: Professor Jonathan Hodgkin has been awarded the prestigious Edward Novitski prize for 2017 by the Genetics Society of America, in recognition of his
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Ashok Venkitaraman Winner of 2017 Basser Global Prize - MRC…
https://www2.mrc-lmb.cam.ac.uk/ashok-venkitaraman-winner-2017-basser-global-prize/30 Nov 2017: The Basser Center for BRCA at Penn’s Abramson Cancer Centre has announced that Ashok Venkitaraman is the recipient of its fifth annual Basser Global Prize
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Building better brains: A bioengineered upgrade for organoids - MRC…
https://www2.mrc-lmb.cam.ac.uk/building-better-brains-bioengineered-upgrade-organoids/1 Jun 2017: Study by Madeline Lancaster and collaborators at IMBA is one of the first attempts to combine organoids with bioengineering. More...
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Richard Henderson shares 2017 Nobel Prize in Chemistry - MRC…
https://www2.mrc-lmb.cam.ac.uk/richard-henderson-shares-2017-nobel-prize-chemistry/6 Oct 2017: The Nobel prize in chemistry has been awarded to three scientists, Jacques Dubochet, Joachim Frank and the LMB's Richard Henderson, for developing a
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Potassium is critical to circadian rhythms in human red blood cells - …
https://www2.mrc-lmb.cam.ac.uk/potassium-critical-circadian-rhythms-human-red-blood-cells/14 Dec 2017: Published on. 14 December, 2017. An innovative new study from the University of Surrey and John O’Neill’s group from the LMB’s Cell Biology Division has uncovered the secrets
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Anne Bertolotti elected Fellow of the UK Academy of Medical Sciences…
https://www2.mrc-lmb.cam.ac.uk/anne-bertolotti-elected-fellow-uk-academy-medical-sciences/8 May 2017: Anne has made outstanding contributions to our understanding of the molecular mechanisms underpinning neurodegenerative diseases and discovered a new drug candidate (Sephin1) that brings hope for the treatment of some
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Alison Woollard is guest on BBC Radio 4, ‘The Life Scientific’ - MRC…
https://www2.mrc-lmb.cam.ac.uk/alison-woollard-guest-bbc-radio-4-life-scientific/2 Mar 2017: Alison Woollard, LMB 1996-2000, Postdoctoral Fellow, Cell Biology Professor Alison Woollard, from the Department of Biochemistry at the University of
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Dynamic structure of human DNA repair enzyme, ATM, revealed - MRC…
https://www2.mrc-lmb.cam.ac.uk/dynamic-structure-human-dna-repair-enzyme-atm-revealed/11 May 2017: LMB News:Primary Sidebar. Search. Search this website. 2024 MRC Laboratory of Molecular Biology,.
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Creating a genomic map of the immune response – Sarah Teichmann - MRC …
https://www2.mrc-lmb.cam.ac.uk/creating-genomic-map-immune-response-sarah-teichmann/13 Jan 2017: Sarah Teichmann, LMB 1996-1999 & 2001-2013, PhD student & programme leader, Structural Studies Division Dr Sarah Teichmann, Head of Cellular
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IL-17, a regulator of the immune system, impacts behaviour - MRC…
https://www2.mrc-lmb.cam.ac.uk/il-17-regulator-immune-system-impacts-behaviour/19 Jan 2017: The state of the immune system has effects on brain function, but despite suggestions that immunoregulators can affect people’s mood and behaviour, we are
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Anne Bertolotti receives GlaxoSmithKline Award from the Biochemical…
https://www2.mrc-lmb.cam.ac.uk/anne-bertolotti-receives-glaxosmithkline-award-biochemical-society/11 Apr 2017: The GlaxoSmithKline Award is given in recognition of research leading to new advances in medical science and is made in respect of research carried out in the UK or the Republic ... Anne has made outstanding contributions to our understanding of the
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First atomic structures of Tau filaments from Alzheimer’s disease…
https://www2.mrc-lmb.cam.ac.uk/first-atomic-structures-tau-filaments-alzheimers-disease-brain/6 Jul 2017: The development of new software by Shaoda He and Sjors was crucial for calculating the structures of the filaments to sufficient detail to deduce the arrangement of the atoms inside them. ... This opens up new possibilities to study a range of other
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Richard Henderson shares Wiley Prize in Biomedical Sciences - MRC…
https://www2.mrc-lmb.cam.ac.uk/richard-henderson-shares-wiley-prize-biomedical-sciences/23 Feb 2017: The 16th annual Wiley Prize in Biomedical Sciences will be awarded to Joachim Frank, Richard Henderson, and Marin van Heel for pioneering developments in
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Christopher Russo awarded the Microscopy Society of America Burton…
https://www2.mrc-lmb.cam.ac.uk/christopher-russo-awarded-microscopy-society-america-burton-medal/12 Apr 2017: Following this, he held a post-doctoral position in the Physics Department of Harvard, where he developed a new technique to create nanopores in graphene with atomic precision. ... so as to enable the development of new devices, instruments and methods
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Amino acid homorepeats influence the function and evolution of…
https://www2.mrc-lmb.cam.ac.uk/amino-acid-homorepeats-influence-function-evolution-proteins/15 Aug 2017: New work spearheaded by Sreenivas Chavali in Madan Babu’s group in the LMB’s Structural Studies Division has shown that homorepeat-containing proteins (HRPs) are not always bad, and can ... It opens new horizons for answering questions about how
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Melina Schuh - exploring why older women find it harder to fall…
https://www2.mrc-lmb.cam.ac.uk/melina-schuh-exploring-older-women-find-harder-fall-pregnant/28 Nov 2017: Published on. 28 November, 2017. Dr Melina Schuh’s new laboratory at Bourn Hall Clinic is carrying out ground-breaking research into human eggs.
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Kim Nasmyth awarded 2018 Breakthrough Prize in Life Sciences - MRC…
https://www2.mrc-lmb.cam.ac.uk/kim-nasmyth-awarded-2018-breakthrough-prize-life-sciences/6 Dec 2017: Professor Kim Nasmyth has been awarded the 2018 Breakthrough Prize in Life Sciences, which recognises transformative advances towards understanding living
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Folate and formaldehyde: from vitamin to genotoxin to DNA building…
https://www2.mrc-lmb.cam.ac.uk/folate-and-formaldehyde-from-vitamin-to-genotoxin-to-dna-building-block/17 Aug 2017: This new research has several implications. Formaldehyde, which is apparently ubiquitous in our environment and lifestyles, is a well-known toxin to humans. ... bypass such approaches by using the new formaldehyde cycle discovered in this work.
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How astrocytes control circadian time-keeping in our principal body…
https://www2.mrc-lmb.cam.ac.uk/astrocytes-control-circadian-time-keeping-principal-body-clock/13 Mar 2017: Research lead by Marco Brancaccio, in Michael Hastings’s group in the LMB’s Neurobiology Division, has recently cast an entirely new light on the properties and activities of the astrocytes ... This study may provide new opportunities to control the
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Xiaochen Bai - first atomic structure from UTSW's Cryo-EM…
https://www2.mrc-lmb.cam.ac.uk/xiaochen-bai-first-atomic-structure-utsws-cryo-em-facility/13 Oct 2017: UT Southwestern Medical Center researchers have published a 3-D atomic structure of the ion channel found in mammals that is implicated in a rare,
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First complete 3D genome structure from individual mammalian cells -…
https://www2.mrc-lmb.cam.ac.uk/first-complete-3d-genome-structure-individual-mammalian-cells/13 Mar 2017: However, using a new chromosome conformation capture technique, Tim Stevens from the LMB’s Cell Biology Division, in collaboration with Ernest Laue’s group in the University of Cambridge Department of
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LMB scientist wins ‘Best Technology’ prize in the 2017 Biomaker…
https://www2.mrc-lmb.cam.ac.uk/lmb-scientist-wins-best-technology-prize-2017-biomaker-challenge/16 Nov 2017: The LMB’s Wolfgang Schmied, in collaboration with Stéphanie Polderdijk from the Cambridge Institute for Medical Research, won ‘Best Technology’ prize in
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Antibodies co-opt anti-microbial response to clear intraneuronal tau…
https://www2.mrc-lmb.cam.ac.uk/antibodies-co-opt-anti-microbial-response-clear-intraneuronal-tau/18 Jan 2017: Leo James and Michel Goedert, group leaders at the LMB, recently published work in PNAS providing an explanation for how therapeutic antibodies eliminate
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Cell lineage tracing – from pioneer John Sulston, to today’s…
https://www2.mrc-lmb.cam.ac.uk/cell-lineage-tracing-pioneer-john-sulston-todays-ground-breaking-research/6 Jul 2017: elegans. Using new cutting-edge technologies, researchers across the world are now aiming to trace cell lineages in a variety of other organisms.
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Brad Amos to talk at Cambridge Science Festival: Monday 20th March,…
https://www2.mrc-lmb.cam.ac.uk/brad-amos-talk-cambridge-science-festival-monday-20th-march-6-00pm/27 Feb 2017: In his talk entitled, ‘Life through a lens’, Brad will show spectacular new 3D images of mouse embryos, possible due to his development of the Mesolens that achieves unparalleled resolution throughout
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