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17 Jan 2024: 11 people are currently waiting for schedule 1 training. have two new NACWO’s added to the PEL,. ... It was agreed this would be useful for new project licences and amendments.

28 Feb 2024: Project Licences (a) New licence: The committee discussed the following:. • Further consideration should be given to the lay person in regards to the Non-Technical Summary and this should also be

14 May 2024: The Home Office attended LASA and discussed the change program but there was nothing new to report. ... 9. Training and Competencies There is a new member of staff starting on January 30th replacing.

10 Oct 2023: Project Licences (a) New licence: The committee discussed the following:. • Several typographical errors that require amending. • ... The committee requested a report in 6 months’ time which includes how the new plan for.

10 Oct 2023: Further details around any new monitoring techniques in the Refinement sections. • ... affected how new licences have been written in Section 4.4. • The committee commended the thorough completion of the Retrospective Review and attention to.

14 May 2024: The Home Office has asked for a report after every new and amended PPL has gone through an AWERB meeting. ... The Guildhall has pulled out due to building work and the new location is yet to be confirmed.

17 Jan 2024: 2. Matters Arising. asked everyone to introduce themselves as there are new staff members in attendance. ... Thank you to everyone who is using the new template and RCA email address.

14 May 2024: The new ASPeL system is due to go live on 31st August however, some technical issues are still ongoing with the Project Licenses. ... Page 3 of 4. 7. Training Centre Manager’s Report. confirmed that the core DOPs assessments for new starters should be

10 Oct 2023: b) New Licence: The committee discussed the following:. • Re-wording required in regards to step 3 of Protocol 2. • ... c) New Licence: The committee discussed the following:. • Further explanation required in regards to ageing animals in the

30 Apr 2024: Project Licences (a) New licence: was also in attendance) The committee discussed the following:. • ... Page 2 of 4. (b) New Licence: was also in attendance) The committee discussed the following:. •

23 Jan 2024: Also welcome to the new UBS Admin Assistant who started 2 weeks ago. ... A new area has been created to accommodate this. Some comments around runting and animals being marked as small have now been split to allow small to refer to adults.

14 May 2024: The 3Rs Committee wish all the best for her new job in The Netherlands. •

14 May 2024: The committee were pleased to see refinements previously developed with collaborators being brought forward into this new licence. •

28 Nov 2023: Project Licences (a) New licence: were also in attendance) The committee discussed the following:. • ... The importance of communication the new Licence Holder must have with the animal facility staff on a day to day basis, that they will be

28 Nov 2023: Consideration given to whether the new objective 6 should apply to Protocols 5 and 6. •

5 Jul 2023: 1d) Apologies: Minutes: 1. Project Licences (a) New licence: was also in attendance) The committee discussed the following:. • ... c) New Licence: The committee discussed the following:. • The recommendation that the applicant reviews the

30 Apr 2024: Our plan is to publish research papers with new information on which human diseases involve programmed axon death and which specific people are most at risk. ... As we have shown, when a new 3Rs method becomes available (e.g., hiPSC-derived neurons), we

29 Apr 2024: What's the aim of this project? The overall aim of the research is to develop new and improved vaccines. ... New vaccines need to be safe, well tolerated, effective and offer broad coverage against many pathogens.

30 Apr 2024: Human embryos are highly inaccessible for research. We use animals to test new experimental approaches, and the knowledge gained can be used to investigate similar events in precious human fetuses and ... We have reduced significantly the number of mice

30 Apr 2024: Our findings will help both clinical and basic science research in reproductive biology and epigenetics to generate new research questions. ... Culture methods for human placental trophoblast cells are very new and still under development.

29 Apr 2024: Animals will be brought in and allowed to acclimatise for a few weeks - this helps them to relax in their new surroundings, gets them used to the staff and human contact ... bones, which acts as a shock absorber), to which the new implant/therapy will be

30 Apr 2024: In work under this licence we aim to identify new treatments for CKD, AKI and NAFLD. ... project? We hope to optimise new imaging efficacy endpoints that will allow assessment of animals over time.

30 Apr 2024: For each stock a new generation will be grown every 18 months (3.3 generations per line in 5 years). ... For each we will breed a new generation every 18 months (2560x3.3=8448).

30 Apr 2024: For example, understanding how cell identity can contribute to diseases may help in the discovery of new treatments. ... I am currently on the European Xenopus Resource Steering Committee where new developments in frog husbandry are often discussed.

30 Apr 2024: 1. New mouse models of mitochondrial disease which carry mutations similar to those found in humans. ... The remaining 20% will be neonates (new born pups up to weaning - approx.

30 Apr 2024: 6.1 million deaths annually (https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death). ... This is confounded by the fact that there have been very few new antimicrobial products that have been developed over the last 15 years.

30 Apr 2024: We will make a new generation for each line every year (5 generations per line). ... In addition, when generating new genetically modified lines, the F0 embryos need to be genotypically screened.

30 Apr 2024: To the wider pharmaceutical industry and patients this could lead into the development of new anti-cancer therapies. ... Pilot studies are used to establish the correct dose of reagents/cells, timelines, and to generate baseline data for new experiments.

29 Apr 2024: This could lead to development of new therapies that are more effective and cause fewer side effects to patients. ... More specifically, we expect to generate at least one new therapy and advance it to a stage that it can be investigated further in large

30 Apr 2024: To enable us to decide what doses of new treatments we need to use in our respiratory and immunology disease models. ... There are multiple stages of non-animal screening of new molecules that are in place before testing in rodent.

29 Apr 2024: goal by enabling us to test new therapeutic hypothesis in vivo relevant to new treatments for immune mediate diseases. ... This de-risks again the potential for using new therapeutic agents which are unlikely to achieve active concentrations at the

30 Apr 2024: benefit people living with mental health disorders through the development of new treatments. ... We also expect, in the medium term, that our research will lead to the development of new behavioural treatments.

29 Apr 2024: Discoveries made on new bacterial species will be published and available to other researchers. ... We continuously consider their use and development in light of new experimental data.

30 Apr 2024: Some of these methods are aimed at providing information to develop new therapies for these diseases. ... We are developing new ways to image cancer and inflammation and find novel ways of treating these diseases.

30 Apr 2024: Our findings should guide these attempts and clarify the mechanisms of action these new therapies employ. ... When animals are exposed to new diets or environments they receive training sessions.

30 Apr 2024: There is no cure for neurodegenerative disorders and thus, finding a new common target is at utmost importance. ... We have created new mouse lines with specific mutations in genes that disrupt one of the stress response pathway that is called

30 Apr 2024: In the short term, the scientific community will gain new information on the pathways and genes that we will investigate. ... Numbers are being adjusted in Dec 2022 following the obtention of new research funding.

29 Apr 2024: For breeding design we use several online resources, especially when bringing in a new strain. ... care for our strains and to identify any new and better treatments that could be utilised.

29 Apr 2024: The new bedding material generated much less dust. What published best practice guidance will you follow to ensure experiments are conducted inthe most refined way? ... Therefore, the project licence holder will have regular discussions with the Named

30 Apr 2024: This means that others do not need to generate new mutants or samples, minimising animal numbers. ... For any new procedures we will review published protocols from experienced collaborators before conducting any experiments.

30 Apr 2024: In new systems pilot studies are utilised to ensure the system works as intended with a small group (e.g. ... Mice would also be habitualised to a new restraint before, e.g., BP measurement.

30 Apr 2024: until we require new offspring. ... I will also have regular discussions with the Named Persons and animal technicians to review current approaches and whether there are any new 3R opportunities.

30 Apr 2024: These new discoveries will be shared with others at local, national and international scientific meetings and in widely available publications. ... In more detail, it is our expectation that our research will produce one new.

30 Apr 2024: Also, these devices will help us learn more about these diseases and might help find even more new treatments. ... Subscribing to the NC3Rs newsletter (https://www.nc3rs.org.uk/news) to receive regular updates on new ideas and research related to the 3Rs.

30 Apr 2024: Both are important immunological processes and targets for the development of new drugs. ... There is a great unmet clinical need in this area and our experiments could inform the development of new therapeutics.

30 Apr 2024: The treatments that are validated in the project may include new intellectual property. ... Altogether, these will generate a blueprint for clinical studies, which will bring successful new treatments to patients.

30 Apr 2024: suffer from traumatic brain injuries and 14 million new incidents of stroke globally, each year. ... may require the generation of new transgenic animals, therefore reducing the number of animals needed to fulfil the objectives we set up in this license.

30 Apr 2024: Ultimately, the intention is that this research will lead to new treatments being developed for mood, anxiety and stress-related mental health disorders. ... benefit people living with mental health disorders through the development of new treatments.

30 Apr 2024: If the pilot experiment raises unexpected new questions, a subsequent pilot experiment will be performed. ... We will routinely check the NC3R's resource library and keep abreast with, and implement where appropriate, any new advances in refinement,

30 Apr 2024: relevant disease animal models to give us an extra layer of confidence in developing these new medications. ... In all new studies undertaken, the level of insult will be assessed before conducting further studies.