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30 Apr 2024: There is an urgent need for new drugs and therapies to slow, delay and prevent proteinopathy diseases. ... Overall, we hope to identify new genes and compounds that allow us to better understand and manipulate neurodegeneration.

30 Apr 2024: Finally, full training will be provided to new technicians who are unfamiliar with these procedures. ... This will ensure that we maintain compliance should any new updates be posted.

30 Apr 2024: As new molecular targets involved in diseases are discovered, the imaging agents that are required for imaging them need to be developed and evaluated in a manner similar to the drug ... When new drugs for removing these proteins are being developed it

29 Apr 2024: On rare occasions, a new drug being tested can have unexpected adverse effects. ... Pilot studies will be employed when first attempting growth of a new source of human immune cells.

30 Apr 2024: Knowledge generated from this work will open new avenues to eradicate whipworm and hookworm infections and control immune-mediated diseases. ... By the end of this project, we will have new information on the host-whipworm relationship, including (1) how

29 Apr 2024: New knowledge will be disseminated in. PPL number: | Granted: 17 Feb 23 | Amended: 23 Aug 23 | Expires: 17 Feb 28. ... The majority of our vaccine studies can be considered "pilot studies" as we are measuring immune responses to new vaccines.

30 Apr 2024: Therefore, the proposed work in this new project licence may hasten translation to relatively simple but novel human clinical interventions to not only treat the mother, but also her progeny. ... Therefore, the project licence holder will have regular

30 Apr 2024: We will generate new insight into the major biological processes underlying inflammatory diseases. ... This enables the development of new therapeutics, exploiting our discoveries. Species and numbers of animals expected to be used.

30 Apr 2024: This project will provide important information that aids the progression of new drugs against bleeding disorders through the drug discovery and development process. ... for our studies and to identify any new and better methods that could be utilised.

30 Apr 2024: We will incorporate new recommendations on animal rearing and welfare as we have done up to now. ... We stay up-to-date with new information and new resources as they become available.

30 Apr 2024: This project will generate important data in the preclinical development of potential new drugs for metabolic and cardiovascular disease. ... This will include investigation of any potential unwanted side effects that could be caused by the new drugs.

30 Apr 2024: Results will open avenues to developing new therapies to treat pain and neurodegeneration. ... Have regular discussions with the Named Persons and animal technicians within the facility to review current approaches and whether there are any new 3Rs

30 Apr 2024: Ultimately, this project will contribute to the successful development of new drugs, which will benefit patients with the diseases being treated. ... make use of any new knowledge or better methods of performing animal studies.

30 Apr 2024: By disseminating our observations from early stages, for example via conferences, we create new collaborations with experts in research fields beyond our own. ... We will carry out pilot studies when new substances, radiation doses, or genetically

30 Apr 2024: least 5-10 new anti-cancer drugs using these models, or currently available models. ... Mice are the most common type of animal used for developing new cancer treatments.

30 Apr 2024: We are following this research field closely and will replace animal research where we can as new technologies develop and are tested and established. ... We also discuss with other groups doing similar research and have an open policy whereby new

30 Apr 2024: Furthermore, we have an extensive tissue bank of samples that can be utilised prior to generating new animal cohorts. ... Our group will attend termly facility user committee meetings where new information is disseminated.

29 Apr 2024: activities including publications in magazines, news articles, blogs, and via twitter / social media feeds. ... We will perform pilot experiments, for e.g. to check the effectiveness of new therapies.

30 Apr 2024: However, the underlying reasons (which could offer new therapies) are only partially understood. ... might be doing regarding animal research and ensure our methods stay updated within the new refinements implemented by others.

30 Apr 2024: The outputs of this licence will likely result in a new information and publications of the following:. ... With this knowledge gained we can identify new testable pathways for augmenting regeneration.

30 Apr 2024: Monoclonal antibodies are expected to become a new standard of care in veterinary medicine. ... In order to predict protein structures and design new proteins, large language models (LLMs) are used.

29 Apr 2024: Similarly, it would not be possible to develop new treatments for brain disorders without testing them in animal models first. ... Any new procedure, or combination of procedures, used under this project licence will systematically be previously

30 Apr 2024: We have chosen to work with a new world monkey, the common marmoset. ... When we embark on a new study we tend to start off with 2 lead animals in which we test out our hypothesis.

30 Apr 2024: memory symptoms, guiding new treatment strategies as well as providing insight into the mechanisms by which current therapies have their efficacious actions. ... When I embark on a new study, I start off with 2 lead animals in.