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  2. AWERB 3Rs Minutes 7th February 2024

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_070224_redacted.pdf
    30 Apr 2024: further details could be included in section 3.7. 4. Project Licence Applications – New / Amendments.
  3. AWERB 3Rs Minutes 3rd January 2024

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_030124_redacted.pdf
    30 Apr 2024: 4. Retrospective Assessment. N/A. 5. Project Licence Applications – New / Amendments N/A.
  4. AOC Minutes 23rd February 2024

    https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_230224_redacted.pdf
    25 Apr 2024: 3. Establishment Licence Holder Report/Update. No report. Minutes. New NIO starting 8th April, , he is coming from. ... Replacing and roles are ongoing. Two new senior posts have been offered in and.
  5. AOC Minutes 19th January 2024

    https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_190124_redacted.pdf
    25 Apr 2024: There is a new form to use but the submission process remains the same. ... It was requested that when adds a new procedure on MCMS, the NTCOs are told so review frequency can be checked.
  6. AWERB Standing Minutes 24th January 2024

    https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_240124_redacted.pdf
    30 Apr 2024: 1. Project Licences (a) New licence - ( was also in attendance) The committee discussed the following:. • ... b) Amendment - The committee discussed the following:. • Inclusion of any benefits that will be gained from this amendment that will balance
  7. AOC Minutes 22nd March 2024

    https://www.ubs.admin.cam.ac.uk/system/files/public/aoc_minutes_220324_redacted.pdf
    25 Apr 2024: and have been removed as NACWOS from the Establishment Licence. Welcome in her new role as Licence Manager. ... The training programme is expected to take around 18 months. This will hopefully help bring in new recruits.
  8. AWERB Standing Minutes 28th February 2024_Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_280224_redacted.pdf
    30 Apr 2024: Project Licences (a) New licence: ( were also in attendance) The committee discussed the following:. • ... c) New Licence: The committee discussed the following:. • Further explanation required in regards to symbols used in the Aims section. •
  9. AWERB Standing Minutes 27th March 2024

    https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_270324_redacted.pdf
    30 Apr 2024: Project Licences (a) New licence: was also in attendance) The committee discussed the following:. • ... Page 2 of 4. (b) New Licence: was also in attendance) The committee discussed the following:. •
  10. Developing new mulivalent recombinant vaccines platforms against…

    https://www.ubs.admin.cam.ac.uk/system/files/public/developing_new_multivalent_recombinant_vaccines_platforms_against_infectious_diseases._non-technic_redacted.pdf
    29 Apr 2024: What's the aim of this project? The overall aim of the research is to develop new and improved vaccines. ... New vaccines need to be safe, well tolerated, effective and offer broad coverage against many pathogens.
  11. Axon degeneration and repair (non-technical summary)

    https://www.ubs.admin.cam.ac.uk/system/files/public/axon_degeneration_and_repair_non-technical_summary_redacted.pdf
    30 Apr 2024: Our plan is to publish research papers with new information on which human diseases involve programmed axon death and which specific people are most at risk. ... As we have shown, when a new 3Rs method becomes available (e.g., hiPSC-derived neurons), we
  12. Placental epignetic programming

    https://www.ubs.admin.cam.ac.uk/system/files/public/placental_epigenetic_programming_non-technical_summary_redacted.pdf
    30 Apr 2024: Our findings will help both clinical and basic science research in reproductive biology and epigenetics to generate new research questions. ... Culture methods for human placental trophoblast cells are very new and still under development.
  13. Early human development and the germline (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/early_human_development_and_the_germline_non-technical_summary_redacted.pdf
    30 Apr 2024: Human embryos are highly inaccessible for research. We use animals to test new experimental approaches, and the knowledge gained can be used to investigate similar events in precious human fetuses and ... We have reduced significantly the number of mice
  14. Cartilage repair and replacement

    https://www.ubs.admin.cam.ac.uk/system/files/public/cartilage_repair_and_replacement_non-technical_summary_redacted.pdf
    29 Apr 2024: Animals will be brought in and allowed to acclimatise for a few weeks - this helps them to relax in their new surroundings, gets them used to the staff and human contact ... bones, which acts as a shock absorber), to which the new implant/therapy will be
  15. New treatments for renal and liver disease (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatments_for_renal_and_liver_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: In work under this licence we aim to identify new treatments for CKD, AKI and NAFLD. ... project? We hope to optimise new imaging efficacy endpoints that will allow assessment of animals over time.
  16. In vivo compressive forces (non-technical summary)_Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/in_vivo_compressive_forces_non-technical_summary_redacted.pdf
    30 Apr 2024: For each stock a new generation will be grown every 18 months (3.3 generations per line in 5 years). ... For each we will breed a new generation every 18 months (2560x3.3=8448).
  17. Models of mitochondrial diseases, pathogenesis and therapy

    https://www.ubs.admin.cam.ac.uk/system/files/public/models_of_mitochondrial_diseases_pathogenesis_and_therapy_non-technical_summary_redacted.pdf
    30 Apr 2024: 1. New mouse models of mitochondrial disease which carry mutations similar to those found in humans. ... The remaining 20% will be neonates (new born pups up to weaning - approx.
  18. Mechanisms controlling cell division and cell identity during…

    https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_controlling_cell_division_and_cell_identity_during_development_reprogramming_and_disease_redacted.pdf
    30 Apr 2024: For example, understanding how cell identity can contribute to diseases may help in the discovery of new treatments. ... I am currently on the European Xenopus Resource Steering Committee where new developments in frog husbandry are often discussed.
  19. Understanding Infection Pathogenesis to Guide Therapies…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_infection_pathogenesis_to_guide_therapies_non-technical_summary_redacted.pdf
    30 Apr 2024: 6.1 million deaths annually (https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death). ... This is confounded by the fact that there have been very few new antimicrobial products that have been developed over the last 15 years.
  20. Mechanisms of organ development and disease (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_of_organ_development_and_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: We will make a new generation for each line every year (5 generations per line). ... In addition, when generating new genetically modified lines, the F0 embryos need to be genotypically screened.
  21. Interaction between the immune system and tumours (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/interaction_between_the_immune_system_and_tumours_non-technical_summary_redacted.pdf
    30 Apr 2024: To the wider pharmaceutical industry and patients this could lead into the development of new anti-cancer therapies. ... Pilot studies are used to establish the correct dose of reagents/cells, timelines, and to generate baseline data for new experiments.

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