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29 Apr 2024: This could lead to development of new therapies that are more effective and cause fewer side effects to patients. ... More specifically, we expect to generate at least one new therapy and advance it to a stage that it can be investigated further in large

30 Apr 2024: To enable us to decide what doses of new treatments we need to use in our respiratory and immunology disease models. ... There are multiple stages of non-animal screening of new molecules that are in place before testing in rodent.

29 Apr 2024: goal by enabling us to test new therapeutic hypothesis in vivo relevant to new treatments for immune mediate diseases. ... This de-risks again the potential for using new therapeutic agents which are unlikely to achieve active concentrations at the

30 Apr 2024: benefit people living with mental health disorders through the development of new treatments. ... We also expect, in the medium term, that our research will lead to the development of new behavioural treatments.

30 Apr 2024: There is no cure for neurodegenerative disorders and thus, finding a new common target is at utmost importance. ... We have created new mouse lines with specific mutations in genes that disrupt one of the stress response pathway that is called

29 Apr 2024: Discoveries made on new bacterial species will be published and available to other researchers. ... We continuously consider their use and development in light of new experimental data.

30 Apr 2024: Some of these methods are aimed at providing information to develop new therapies for these diseases. ... We are developing new ways to image cancer and inflammation and find novel ways of treating these diseases.

29 Apr 2024: For breeding design we use several online resources, especially when bringing in a new strain. ... care for our strains and to identify any new and better treatments that could be utilised.

30 Apr 2024: Our findings should guide these attempts and clarify the mechanisms of action these new therapies employ. ... When animals are exposed to new diets or environments they receive training sessions.

30 Apr 2024: In the short term, the scientific community will gain new information on the pathways and genes that we will investigate. ... Numbers are being adjusted in Dec 2022 following the obtention of new research funding.

29 Apr 2024: The new bedding material generated much less dust. What published best practice guidance will you follow to ensure experiments are conducted inthe most refined way? ... Therefore, the project licence holder will have regular discussions with the Named

30 Apr 2024: until we require new offspring. ... I will also have regular discussions with the Named Persons and animal technicians to review current approaches and whether there are any new 3R opportunities.

30 Apr 2024: In new systems pilot studies are utilised to ensure the system works as intended with a small group (e.g. ... Mice would also be habitualised to a new restraint before, e.g., BP measurement.

30 Apr 2024: This means that others do not need to generate new mutants or samples, minimising animal numbers. ... For any new procedures we will review published protocols from experienced collaborators before conducting any experiments.

30 Apr 2024: These new discoveries will be shared with others at local, national and international scientific meetings and in widely available publications. ... In more detail, it is our expectation that our research will produce one new.

30 Apr 2024: Also, these devices will help us learn more about these diseases and might help find even more new treatments. ... Subscribing to the NC3Rs newsletter (https://www.nc3rs.org.uk/news) to receive regular updates on new ideas and research related to the 3Rs.

30 Apr 2024: Both are important immunological processes and targets for the development of new drugs. ... There is a great unmet clinical need in this area and our experiments could inform the development of new therapeutics.

30 Apr 2024: suffer from traumatic brain injuries and 14 million new incidents of stroke globally, each year. ... may require the generation of new transgenic animals, therefore reducing the number of animals needed to fulfil the objectives we set up in this license.

30 Apr 2024: The treatments that are validated in the project may include new intellectual property. ... Altogether, these will generate a blueprint for clinical studies, which will bring successful new treatments to patients.

30 Apr 2024: Ultimately, the intention is that this research will lead to new treatments being developed for mood, anxiety and stress-related mental health disorders. ... benefit people living with mental health disorders through the development of new treatments.