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Cryo‐EM structure of the full‐length Lon protease from Thermus…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Lon%20Coscia%202021%20FEBS.pdf14 Nov 2021: The new model containing a coiled-coil. a-helix describes map 2 well. ... Hagen WJH, Lindahl E and Scheres SHW (2018) New. tools for automated high-resolution cryo-EM structure. -
BIO CHEM ISTR Y Structure of the SARS-CoV-2 RNA-dependent ...
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/SARS%20polym%202021%20e2021946118.full.pdf29 Aug 2021: High-resolution structure deter-mination may aid in these directions as new compounds are developed andtested as treatments for COVID-19. ... 9, 2. 021. 20. J. Zivanov et al., New tools for automated high-resolution cryo-EM structuredetermination in -
Coot Scripting Interface: File Members
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/globals_0x64.html24 Aug 2021: default_new_atoms_b_factor() : c-interface.h. -
Francis Crick (1916 - 2004) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/francis-crick-1916-2004/30 Mar 2021: the centre of the new field of molecular biology.
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Mark Bretscher - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/mark-bretscher/30 Mar 2021: Mark S. Bretscher Mark Bretscher studied Chemistry at the University of Cambridge, before joining the MRC Laboratory of Molecular biology as a research
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Heart cell clocks help coordinate daily cardiac function - MRC…
https://www2.mrc-lmb.cam.ac.uk/heart-cell-clocks-help-coordinate-daily-cardiac-function/21 Oct 2021: Cell Biology Group Leader, John O’Neill, discusses his group’s recent paper. Their work highlights how heart cells regulate daily function through
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Francis Crick Lecture to be given by Michel C. Nussenzweig - MRC…
https://www2.mrc-lmb.cam.ac.uk/francis-crick-lecture-to-be-given-by-michel-c-nussenzweig/8 Nov 2021: Michel received a B.C. summa cum laude from New York University in 1976, a PhD degree with Ralph Steinman from Rockefeller University in 1981 and an M.D. ... degree from New York University Medical School in 1982. Following this he completed a medical
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Michel Goedert awarded the 2021 Hartwig Piepenbrock-DZNE Prize - MRC…
https://www2.mrc-lmb.cam.ac.uk/michel-goedert-awarded-the-2021-hartwig-piepenbrock-dzne-prize/15 Oct 2021: Hopefully, the new knowledge will lead to the development of safe and effective mechanism-based therapies for common neurodegenerative diseases.”.
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Wasi Faruqi awarded MBE in Queen’s Birthday Honours - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/wasi-faruqi-awarded-mbe-in-queens-birthday-honours/14 Jun 2021: Wasi (Abdul Raffey) Faruqi, from the LMB’s Structural Studies Division, has been made a MBE in the Queen’s 2021 Birthday Honours List
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John Finch Collection - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/archive/scientific-models/john-finch-collection/31 Mar 2021: He came to the new LMB in 1962 with the Birkbeck group, which was now led by Aaron Klug after Rosalind’s death in 1958.
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Max Perutz (1914 - 2002) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/max-perutz-1914-2002/30 Mar 2021: This move would lead to him becoming a pioneer in the new field of molecular biology, co-founding a world-class research laboratory and developing a technique to unlock the structures
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César Milstein Lecture to be given by Hans Clevers - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/cesar-milstein-lecture-to-be-given-by-hans-clevers/23 Nov 2021: Hans Clevers from the Hubrecht Institute will deliver the 2021 César Milstein Lecture on how organoids can be used to model human diseases.
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Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/COVID%20vaccine%202021%201873-3468.14171.pdf29 Aug 2021: Q5 High-Fidelity 2X Master Mix (New England Biolabs,. Ipswich, MA, USA) as per manufacturer’s instructions. -
Coot Scripting Interface: File Members
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/globals_func_0x75.html24 Aug 2021: update_go_to_atom_window_on_new_mol() : c-interface.h. -
A colourful welcome back for the LMB Arts and Crafts Show - MRC…
https://www2.mrc-lmb.cam.ac.uk/a-colourful-welcome-back-for-the-lmb-arts-and-crafts-show/5 Aug 2021: The LMB Arts and Crafts Show: showcasing the creative talents of the LMB
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Madeline Lancaster on serendipity and adventure in science - MRC…
https://www2.mrc-lmb.cam.ac.uk/madeline-lancaster-on-serendipity-and-adventure-in-science/22 Sep 2021: Cell Biology Group Leader Madeline Lancaster discusses how her ‘failed’ attempt to grow neural stem cells led to the development of brain organoids –
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Dr. George Pieczenik - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/dr-george-pieczenik/30 Mar 2021: Dr. George Pieczenik Dr. George Pieczenik worked in the MRC Laboratory of Molecular Biology at intervals during the years 1972-1987. He was an early
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Bretscher Archive - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/archive/manuscripts-correspondence/bretscher-archive/28 Sep 2021: Search this website. Bretscher Archive. The MRC Unit moved out of the Cavendish Laboratory to the new LMB site in early 1962.
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Publications
https://www2.mrc-lmb.cam.ac.uk/groups/rh15/Publications.html14 Apr 2021: Henderson, R. IUCrJ 3, 3-7 (2016). CryoEM at IUCrJ: a new era. ... Caspar, D.L.D. Nature, News & Views 345, 666-667 (1990). Bacteriorhodopsin - at last! -
16262551036386 1..32
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/cohesin%20folding%202021%20elife-67268-v1.pdf14 Jul 2021: For correspondence:. jyl@mrc-lmb.cam.ac.uk (JL);. ashley.nasmyth@bioch.ox.ac.uk. (KAN). †These authors contributed. equally to this work. Competing interests: The. authors declare that no. competing interests exist. Funding: See page 28. Received: -
A unified evolutionary origin for the ubiquitous protein transporters …
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2023/08/BMC_Biology_2021.pdf15 Dec 2021: s hydrophilic groove and its capping hydrophobicresidue are homologous to key residues in SecY’s hydro-philic funnels and its pore ring, respectively.In light of this new correspondence, we -
The mechanisms of integral membrane protein biogenesis
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2023/08/NRMCB_2021.pdf22 Sep 2021: These areas have recently seen the discovery of new machinery, mechanis-tic insights from structural and bioinformatics analysis, and the emergence of new concepts. ... Here we consider comparatively recent new insights into the basis of SRP substrate -
Science Journals — AAAS
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2023/08/Science_2021.pdf26 Aug 2021: The PSMC5 construct for in vitro translation in the PURE system was similar to that in pSP64, but in the T7-based PURExpress plasmid from New England Biolabs. ... The resin was then. 6. washed 5 times in PSB, and transferred to a new tube. -
Coot Scripting Interface: File Members
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/globals_func_0x64.html24 Aug 2021: default_new_atoms_b_factor() : c-interface.h. -
Madeline Lancaster awarded the 2021 ISSCR Dr Susan Lim Award - MRC…
https://www2.mrc-lmb.cam.ac.uk/madeline-lancaster-awarded-the-2021-isscr-dr-susan-lim-award/26 Jan 2021: They found that ChP cells express ACE2, the receptor needed for SARS-CoV-2 entry, on their surface and that the virus was able to infect and produce new virus inside ... The development of cerebral organoids has significant implications not only for
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Hans Boye - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/lmb-alumni-hans-boye/30 Mar 2021: Hans Boye Hans Boye was a research student with Francis Crick from October 1961-1964, and was Crick's second and last student. His area of research was on
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Bernard Jacrot - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/bernard-jacrot/30 Mar 2021: With Maier-Leibnitz, they recruited the young German and French scientists and engineers who designed and built a new generation of instruments (some of which were politely considered to be ‘odd’ ... He established a group in structural virology that
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Chris Tate and Sjors Scheres elected Fellows of Royal Society - MRC…
https://www2.mrc-lmb.cam.ac.uk/chris-tate-and-sjors-scheres-elected-fellows-of-royal-society/6 May 2021: Each year the Fellows of the Royal Society elect up to 52 new Fellows, and up to 10 new Foreign Members. ... Our new Fellows and Foreign Members are all at the forefronts of their fields from molecular genetics and cancer research to tropical open
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Herbert ‘Freddie’ Gutfreund - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/herbert-freddie-gutfreund/18 Nov 2021: Herbert ‘Freddie’ Gutfreund Freddie Gutfreund was born in Vienna on 21st October 1921. In 1938, aged 17, he arrived in England as a refugee, initially to
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Furin protease is not essential for SARS-CoV-2 infection - MRC…
https://www2.mrc-lmb.cam.ac.uk/furin-protease-is-not-essential-for-sars-cov-2-infection/29 Jan 2021: This process might play a role in virus spread between cells even in the absence of production of new virus particles. ... The emergence of new SARS-CoV-2 variants is a real concern as they can threaten the effectiveness of the approved SARS-CoV-2
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Coot Scripting Interface: get-monomer.hh Source File
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/get-monomer_8hh_source.html24 Aug 2021: 43 // return a new molecule number. -
Behind the Scenes with... Steve Scotcher - MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/share-your-memories/steve-scotcher/31 Mar 2021: Original hand-drawn design from the 1980s. Before a new piece of equipment or machinery can be made, we first need to nail down the design. ... More recently, I’ve worked with Richard Henderson and Greg McMullan on various high vacuum test rigs for the
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Graeme Mitchison (1944 - 2018) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/graeme-mitchison-1944-2018/30 Mar 2021: Graeme continued to keep in touch with colleagues and friends at LMB, including celebrating the opening of the new LMB building at the LMB Alumni Symposium in 2014. ... Richard Durbin and the LMB News Team. Primary Sidebar. Search. Search this website.
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Ken Harvey (1926 – 2021) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/ken-harvey-1926-2021/22 Jul 2021: Ken Harvey (1926 – 2021) Ken Harvey joined the LMB on 21st June 1965, as the LMB’s first photographer. He went on to become Head of the Photography
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John Abelson - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/lmb-alumni-john-abelson/30 Mar 2021: John Abelson John Abelson was a postdoc in the Structural Studies Division at LMB from 1965 to 1968, working with Sydney Brenner and Francis Crick on
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Coot Scripting Interface: cc-interface.hh File Reference
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/cc-interface_8hh.html24 Aug 2021: Returns. the molecule number of the new map. Return -1 if unable to make a variance map. ... the function passed to lbg, so that it calls it when a new SBase comp_id is required. -
Sjors Scheres awarded the Leeuwenhoek Medal from the Royal Society -…
https://www2.mrc-lmb.cam.ac.uk/sjors-scheres-awarded-the-leeuwenhoek-medal-from-the-royal-society/24 Aug 2021: For his ground-breaking methodological developments in image processing and analysis in cryo-EM, Sjors Scheres has been awarded the Royal Society’s Leeuwenhoek Medal.
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Uli Arndt (1924 - 2006) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/lmb-alumni-uli-arndt-1924-2006/30 Mar 2021: Uli Arndt (1924 - 2006) His many friends and colleagues around the world will be very sad to learn that Uli died on 24th March, aged 81, from cancer which
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How DNA damage induces appetite suppression and weight loss - MRC…
https://www2.mrc-lmb.cam.ac.uk/how-dna-damage-induces-appetite-suppression-and-weight-loss/24 Nov 2021: DNA damage caused by formaldehyde is repaired involving CSA and CSB genes. KJ Patel’s lab have shown how, when this pathway is mutated such as in people with Cockayne syndrome, the appetite suppression hormone GDF15 is released leading to severe
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M. Madan Babu elected Fellow of the Academy of Medical Sciences - MRC …
https://www2.mrc-lmb.cam.ac.uk/m-madan-babu-elected-fellow-of-the-academy-of-medical-sciences/12 May 2021: M. Madan Babu, former group leader in the LMB’s Structural Studies Division, has been elected into the Fellowship of the Academy of Medical Sciences.
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John Kendrew (1917 - 1997) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/john-kendrew-1917-1997/30 Mar 2021: John Kendrew (1917 - 1997) In 1945, John Kendrew joined Max Perutz at the Cavendish Laboratory in Cambridge. Together they would share three great
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Richard Perham (1937 - 2015) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/richard-perham-1937-2015/30 Mar 2021: Richard Perham (1937 - 2015) Richard Perham died on Saturday 14 February 2015, after a short illness, at the age of 77. Richard began as a PhD student in
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LMB honoured in Cambridge Independent Science and Technology Awards - …
https://www2.mrc-lmb.cam.ac.uk/lmb-honoured-in-cambridge-independent-science-and-technology-awards/20 Apr 2021: The LMB has received a Special Commendation in the category of Covid-19 Response Award, in the Cambridge Independent Science and Technology Awards. Also
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Gerry Rubin: Looking Back - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/share-your-memories/gerry-rubin/31 Mar 2021: Gerry Rubin: Looking Back Gerry Rubin was a PhD student in the Cell Biology Division from 1971-1974. For the December 2019 LMB Alumni Newsletter, he
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KENDREW LECTURE(Part 1) Demis HassabisFounder & CEO DeepMind,…
https://www2.mrc-lmb.cam.ac.uk/?wpdmdl=2135527 Sep 2021: Using AI to accelerate scientific discoveryWednesday 13th October @ 2.30 pmDetails on the LMB website https://www2.mrc-lmb.cam.ac.uk/news-and-events/scientific-seminars/. -
KENDREW LECTURE(Part 2) Wednesday 13th October @ 4.00 pmDetails ...
https://www2.mrc-lmb.cam.ac.uk/?wpdmdl=2135627 Sep 2021: KENDREW LECTURE(Part 2). Wednesday 13th October @ 4.00 pmDetails on the LMB website https://www2.mrc-lmb.cam.ac.uk/news-and-events/scientific-seminars/. -
Coot Scripting Interface: probe-clash-score.hh Source File
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/docs/html/probe-clash-score_8hh_source.html24 Aug 2021: 100 }. 101 }. 102 if (! found) {. 103 one_way_probe_contact_t new_contact(from_atom);. ... 104 new_contact.add(to_atom);. -
Getting close to nature: results of the 2020 Science Image Award… -…
https://www2.mrc-lmb.cam.ac.uk/getting-close-to-nature-results-of-the-2020-science-image-award/5 May 2021: Fourteen primary schools participated in the 2020 Science Image Award competition, with the winning image taken by a child at Barnham Primary School near Thetford.
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Setting the stage: development of sample holders for electron ...
https://www2.mrc-lmb.cam.ac.uk/?wpdmdl=2129521 Jun 2021: Also, parts can move during specimen translation, making a new contact with small temperature differences between the contacting parts. ... 1996 Bob Morrison of Gatan Inc., designed a holder for a new Phillips prototype to be used with liquid helium. -
Maria Leptin has been appointed President of the European Research…
https://www2.mrc-lmb.cam.ac.uk/maria-leptin-has-been-appointed-president-of-the-european-research-council/2 Jul 2021: Published on. 2 July, 2021. Maria Leptin is the new President of the European Research Council starting from 1 October 2021.
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