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  2. LMB and AstraZeneca announce plan to launch joint research fund - MRC …

    https://www2.mrc-lmb.cam.ac.uk/lmb-and-astrazeneca-announce-plan-to-launch-joint-research-fund/
    Thumbnail for LMB and AstraZeneca announce plan to launch joint research fund - MRC Laboratory of Molecular Biology 15 May 2014: The MRC Laboratory of Molecular Biology and AstraZeneca are today announcing a plan for a research fund to facilitate collaboration between LMB and
  3. mRNA on the move – localisation can affect cell signalling and…

    https://www2.mrc-lmb.cam.ac.uk/mrna-on-the-move-localisation-can-affect-cell-signalling-and-regulation/
    Thumbnail for mRNA on the move – localisation can affect cell signalling and regulation - MRC Laboratory of Molecular Biology 26 Aug 2014: Published on. 26 August, 2014. New research from Madan Babu’s group in the LMB’s Structural Studies Division, in collaboration with Toby Gibson from the European Molecular Biology Laboratory in ... However in some cases, the mRNA molecules that code
  4. Madan Babu awarded the Protein Society’s 2014 Protein Science Young…

    https://www2.mrc-lmb.cam.ac.uk/madan-babu-awarded-the-protein-societys-2014-protein-science-young-investigator-award/
    Thumbnail for Madan Babu awarded the Protein Society’s 2014 Protein Science Young Investigator Award - MRC Laboratory of Molecular Biology 20 Feb 2014: Madan Babu, from the LMB’s Structural Studies Division, has been announced as the recipient of the Protein Society’s 2014 Protein Science Young
  5. Jason Chin discusses synthetic biology on Guardian Science Weekly…

    https://www2.mrc-lmb.cam.ac.uk/jason-chin-discusses-synthetic-biology-on-guardian-science-weekly-podcast/
    Thumbnail for Jason Chin discusses synthetic biology on Guardian Science Weekly Podcast - MRC Laboratory of Molecular Biology 14 May 2014: Jason explains his own work in the field and why synthetic forms of DNA are crucial both for furthering our understanding of fundamental biology and for creating a new generation of
  6. Speaking at the LMB, George Osborne backs science funding for…

    https://www2.mrc-lmb.cam.ac.uk/speaking-at-the-lmb-george-osborne-backs-science-funding-for-cambridge/
    Thumbnail for Speaking at the LMB, George Osborne backs science funding for Cambridge - MRC Laboratory of Molecular Biology 29 Apr 2014: This article is no longer available from the source website: Cambridge News 25 April 2014.
  7. Scientists map one of most important proteins in life and cancer -…

    https://www2.mrc-lmb.cam.ac.uk/scientists-map-one-of-most-important-proteins-in-life-and-cancer/
    Thumbnail for Scientists map one of most important proteins in life and cancer - MRC Laboratory of Molecular Biology 24 Jul 2014: David Barford and his group, at the LMB and at the Institute of Cancer Research in London, have used cryo-EM to reveal the secondary structure of a vital
  8. refmac 5.8 series

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/refmac/bug_fixes.html
    6 Aug 2014: R.Nicholls. Map sharpeining. It is more like new feature than a bug.
  9. Over 50 LMB scientists showcase research at the Cambridge Science…

    https://www2.mrc-lmb.cam.ac.uk/over-50-lmb-scientists-showcase-research-at-the-cambridge-science-festival/
    Thumbnail for Over 50 LMB scientists showcase research at the Cambridge Science Festival - MRC Laboratory of Molecular Biology 27 Mar 2014: On Saturday 15 and Sunday 16 March over 50 LMB scientists helped to showcase LMB research during the Cambridge Science Festival. The LMB had three
  10. Graphene: stronger than steel and now suitable for biological…

    https://www2.mrc-lmb.cam.ac.uk/graphene-stronger-than-steel-and-now-suitable-for-biological-electron-microscopy/
    Thumbnail for Graphene: stronger than steel and now suitable for biological electron microscopy - MRC Laboratory of Molecular Biology 22 Apr 2014: Chris and Lori made large sheets of graphene using a new custom-made instrument, designed and built here at the LMB. ... They then invented a new way to change the properties of graphene using a hydrogen plasma so they could control how proteins stick to
  11. Insights into how the Fanconi Anaemia core complex activates DNA…

    https://www2.mrc-lmb.cam.ac.uk/insights-into-how-the-fanconi-anaemia-core-complex-activates-dna-repair/
    Thumbnail for Insights into how the Fanconi Anaemia core complex activates DNA repair - MRC Laboratory of Molecular Biology 6 Jun 2014: Eeson developed a new method of purifying the complex from chicken cells by fusing a tag to one of the FA proteins and using this to ‘fish’ out the entire complex.
  12. Major synthetic life breakthrough as LMB scientists make the first…

    https://www2.mrc-lmb.cam.ac.uk/major-synthetic-life-breakthrough-lmb-scientists-make-first-artificial-enzymes/
    Thumbnail for Major synthetic life breakthrough as LMB scientists make the first artificial enzymes - MRC Laboratory of Molecular Biology 2 Dec 2014: laboratory. This milestone from Philipp Holliger’s group at the LMB could soon lead to new ways of developing drugs and medical treatments,Primary Sidebar.
  13. The Chancellor, George Osborne, visits the LMB in his support for…

    https://www2.mrc-lmb.cam.ac.uk/the-chancellor-george-osborne-visits-the-lmb-in-his-support-for-science/
    Thumbnail for The Chancellor, George Osborne, visits the LMB in his support for science - MRC Laboratory of Molecular Biology 25 Apr 2014: He confirmed, “we will deliver, over the next 5 years, the biggest sustained programme of investment in new science capital ever”.
  14. Unexpected role of Histone H3.3 in replication of damaged DNA - MRC…

    https://www2.mrc-lmb.cam.ac.uk/unexpected-role-of-histone-h3-3-in-replication-of-damaged-dna/
    Thumbnail for Unexpected role of Histone H3.3 in replication of damaged DNA - MRC Laboratory of Molecular Biology 16 Sep 2014: This new research suggests that DNA is packaged differently after it has been damaged and that using H3.3 in this way may help cells flag regions of the genome harbouring
  15. Heptares Therapeutics granted key patents for GPCR-Focused Drug…

    https://www2.mrc-lmb.cam.ac.uk/heptares-therapeutics-granted-key-patents-gpcr-focused-drug-discovery-platform/
    Thumbnail for Heptares Therapeutics granted key patents for GPCR-Focused Drug Discovery Platform - MRC Laboratory of Molecular Biology 17 Dec 2014: the National Institute of Medical Research (NIMR) to find new medicines targeting GPCRs.
  16. Paul Elliott awarded a Biochemical Society 2015 Early Career Research …

    https://www2.mrc-lmb.cam.ac.uk/paul-elliott-awarded-a-biochemical-society-2015-early-career-research-award/
    Thumbnail for Paul Elliott awarded a Biochemical Society 2015 Early Career Research Award - MRC Laboratory of Molecular Biology 8 Apr 2014: Paul Elliott, from the LMB’s Protein and Nucleic Acid Chemistry (PNAC) Division, has won the prestigious Biochemical Society Early Career Research Award
  17. Breakthrough in structural biology reveals mitochondrial ribosome…

    https://www2.mrc-lmb.cam.ac.uk/breakthrough-in-structural-biology-reveals-mitochondrial-ribosome-structure/
    Thumbnail for Breakthrough in structural biology reveals mitochondrial ribosome structure - MRC Laboratory of Molecular Biology 28 Mar 2014: new proteins into the EM maps and optimise their fit.
  18. What next after Academia? Three ways to forge a career away from the…

    https://www2.mrc-lmb.cam.ac.uk/what-next-after-academia-three-ways-to-forge-a-career-away-from-the-bench/
    Thumbnail for What next after Academia? Three ways to forge a career away from the bench - MRC Laboratory of Molecular Biology 20 Jun 2014: the new Grants Department at the Babraham Institute.
  19. Protein Synthesis Technology developed at the LMB licenced for use in …

    https://www2.mrc-lmb.cam.ac.uk/protein-synthesis-technology-developed-at-the-lmb-licenced-for-use-in-drug-discovery/
    Thumbnail for Protein Synthesis Technology developed at the LMB licenced for use in drug discovery - MRC Laboratory of Molecular Biology 26 Aug 2014: organisms. GOPAL, which stands for Genetically encoded Orthogonal Protection and Activated Ligation, is a new technology that allows cells to produce proteins that can be linked together in a precise way. ... The technology will help produce new protein
  20. Hugh Pelham discusses research collaboration between LMB and…

    https://www2.mrc-lmb.cam.ac.uk/hugh-pelham-discusses-research-collaboration-between-lmb-and-astrazeneca-in-more-depth/
    Thumbnail for Hugh Pelham discusses research collaboration between LMB and AstraZeneca in more depth - MRC Laboratory of Molecular Biology 20 May 2014: Published on. 20 May, 2014. Mike Scialom talks to Sir Hugh Pelham about why pledge from the MRC LMB and AstraZeneca could mean good news for Cambridge. ... This article is no longer available from the source website: Cambridge News 20 May 2014.
  21. Shedding light on how mRNA molecules navigate to their destination…

    https://www2.mrc-lmb.cam.ac.uk/shedding-light-on-how-mrna-molecules-navigate-to-their-destination-within-the-cell/
    Thumbnail for Shedding light on how mRNA molecules navigate to their destination within the cell - MRC Laboratory of Molecular Biology 15 Apr 2014: Published on. 15 April, 2014. Harish Chandra Soundararajan and Simon Bullock from the LMB’s Cell Biology Division have created a new technique for studying how dynein motors move individual mRNA ... In the current study, unprecedented details of this
  22. 1 Clear StrategyTM Screen I MD1-14 A 6 × ...

    https://www2.mrc-lmb.cam.ac.uk/screens2/pdf/LMB10.pdf
    2 Oct 2014: A new set of conditions can easily be achieved by an increase in the salt or PEG concentration, a shift towards one of the two mixed PEGs or even a change ... Anomalous scattering centres The coupling of new crystallization screens with modern methods to
  23. ProSMART Tutorial - Part 2a

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/tutorials/prosmart_tutorial/files/part_2a.html
    14 Apr 2014: Firstly, follow these steps:. Start a new session - close PyMOL, then re-open it. ... Start a new ProSMART CCP4i job, and load 1ryx.pdb and 1ryx_prosmart_refine.pdb as the target and reference structures, respectively.
  24. Prizewinners Trip to the LMB for Stephen Perse Foundation Senior…

    https://www2.mrc-lmb.cam.ac.uk/prizewinners-trip-to-the-lmb-for-stephen-perse-foundation-senior-school-pupils/
    Thumbnail for Prizewinners Trip to the LMB for Stephen Perse Foundation Senior School pupils - MRC Laboratory of Molecular Biology 8 Jul 2014: An article from their school newsletter shows the pupils who grew crystals in their Chemistry lessons and won first prize in the Eastern Region Crystal
  25. The mother’s role in protecting the fetal genome from aldehyde damage …

    https://www2.mrc-lmb.cam.ac.uk/the-mothers-role-in-protecting-the-fetal-genome-from-aldehyde-damage-is-revealed/
    Thumbnail for The mother’s role in protecting the fetal genome from aldehyde damage is revealed. - MRC Laboratory of Molecular Biology 22 Aug 2014: The fact that the mother can protect the genomic integrity of the developing fetus is a new and significant finding.
  26. ProSMART Tutorial - Part 2b

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/tutorials/prosmart_tutorial/files/part_2b.html
    14 Apr 2014: Firstly, follow these steps:. Start a new session - close CCP4mg, then re-open it. ... Firstly follow these steps:. Start a new session - close CCP4mg, then re-open it.
  27. ProSMART Tutorial - Part 1

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/tutorials/prosmart_tutorial/files/part_1.html
    14 Apr 2014: For our next round of refinement:. Open a new REFMAC5 job in the CCP4i GUI. ... Provide the original 1ryx.mtz structure factor file in the "MTZ in" fields, and provide the new modified model in the "PDB in" field.
  28. JCSG+ Screen

    https://www2.mrc-lmb.cam.ac.uk/screens2/pdf/LMB11.pdf
    2 Oct 2014: A new set of conditions can easily be achieved by an increase in the salt or PEG concentration, a shift towards one of the two mixed PEGs or even a change ... Anomalous scattering centres The coupling of new crystallization screens with modern methods to
  29. PowerPoint Presentation

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/Ligand-meeting-July-9.pptx
    9 Jul 2014: Second option, two candidates. 12. Building the new Dictionary Clustering the data from COD. ... 15. Generator of molecule geometries using the new Dictionary. A “greedy” global optimization scheme.
  30. refmac keywords

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/refmac/refmac_keywords.html
    6 Oct 2014: 2) Put zero inside the sphere centred at current atom with new radius. ... n4 - weighting options. New instructions (a little bit more flexible and useful for complex molecules):.
  31. 7 NOVEMBER 2014 • VOL 346 ISSUE 6210 7 ...

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/90_Shao_S_Science_2014.pdf
    8 Nov 2014: that benefit from bacteria. Validation of. this promising new cell culture model for. ... The power of quantitative proteomics may. well shift how new biological pathways are.
  32. Madeline A. Lancaster Culturing feeder-free human ES cells Modified…

    https://www2.mrc-lmb.cam.ac.uk/groups/lancaster/download/Culturing-feeder-free-human-ES-cells.docx
    21 Mar 2014: 2. Prepare new Matrigel plates as above or warm pre-prepared Matrigel coated dishes in the incubator. ... Add additional media needed. c. Generally minimize pipetting! 8. Transfer 0.5 ml cells per new well and place back in the incubator, being careful
  33. Onl_Er_embj_201488930_GA 1..3

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/86_Hegde_RS_EMBO_2014.pdf
    10 Jun 2014: The new studies focus on tail-anchored. (TA) membrane proteins, defined topologi-.
  34. PowerPoint Presentation

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/ImaginingTheBrain/2014/media/Food_For_Thought.pptx
    30 Apr 2014: Amino acids to make new proteins and neurotransmitters. Vitamins to carry out essential processes, especially B vitamins, and to act as antioxidants (E & C).
  35. MinCD cell division proteins form alternating copolymeric cytomotive…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/ncomms6341.pdf
    6 Dec 2014: analyses, we show that MinD activates MinC by forming a new class of alternating. ... We combined our new crystalstructure with the EcMinD dimer structure, revealing twointeresting features (Fig.
  36. Madeline A. Lancaster Culturing feeder-dependent human iPS/ES cells…

    https://www2.mrc-lmb.cam.ac.uk/groups/lancaster/download/Culturing-human-ES-and-iPS-cells.docx
    21 Mar 2014: Add 1 ml hES media to well. 10. Resuspend hiPSC pellet in 1 ml hES media per new well of 6-well plate and triturate gently with P1000 tip to get ... 7. Wash the old well with another 1 ml hES media and transfer to new well.
  37. Word macros that will translate a highlighted area of ...

    https://www2.mrc-lmb.cam.ac.uk/groups/cartera/download/resources/computer/word_macros/TranslateIncNucleotide2.docx
    4 Feb 2014: Selection.Font.Name = "Courier New". Selection.Font.Size = 8. Selection.TypeText (output).
  38. pone.0107211 1..10

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/leoa2014.pdf
    3 Sep 2014: LeoA, B and C from Enterotoxigenic Escherichia coli(ETEC) Are Bacterial DynaminsKatharine A. Michie1.¤a, Anders Boysen2., Harry H. Low1.¤b, Jakob Møller-Jensen2, Jan Löwe1. 1 MRC Laboratory of Molecular Biology, Structural Studies Division,
  39. DOI: 10.1126/science.1256917, 963 (2014);346 Science et al.Thomas G.…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Science-2014-Gligoris-963-7.pdf
    21 Nov 2014: The title. CopyrightAmerican Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. ... Cross-linking cohesin containing cysteinesat all three interfaces generated a new formform (Ci) whose electrophoretic mobility
  40. INVITED REVIEW Mechanosensory molecules and circuits in C. elegans ...

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-2.pdf
    10 Dec 2014: INVITED REVIEW. Mechanosensory molecules and circuits in C. elegans. William R. Schafer. Received: 3 June 2014 /Revised: 30 June 2014 /Accepted: 2 July 2014 /Published online: 23 July 2014# The Author(s) 2014. This article is published with open
  41. Tutorial 4: Statistical Theory;Why is the Gaussian Distribution so ...

    https://www2.mrc-lmb.cam.ac.uk/download/tutorial-4-statistical-theory/?wpdmdl=18816&refresh=6688095ec58ab1720191326
    20 Mar 2014: 7. Use a ‘for loop’ to iteratively recreate a new random Bin(100, 0.4) sample of100 observations and overplot the corresponding empirical density functionsonto the plot of the Normal density
  42. elifesciences.org van den Ent et al. eLife 2014;3:e02634. DOI: ...

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/mrebdouble2014.pdf
    6 Jun 2014: The elongasome ensures that new glycan strands cross-linked by short peptides are inserted along the peptidoglycan scaffold during cell elongation (den Blaauwen et al., 2008; Goffin and Ghuysen, 1998; Matsuhashi
  43. elifesciences.org Szwedziak et al. eLife 2014;3:e04601. DOI:…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/FtsZ_Piotr_eLife_2014.pdf
    31 Dec 2014: eLife digest Cell division is the process by which new cells are made. ... In the long run, intricate knowledge of how a bacterial cell divides might enable the design of new classes of antibiotics targeting the molecular machinery involved.DOI:
  44. Use and misuse of statistics

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/courses/lmb_statistics_course_2014/lectures/Lecture1_Intro.pptx
    23 Feb 2014: 8. Knowledge. New system. Model. Experiment. Estimate. Verify. Predict. A simple diagram of scientific research: When you know the system. ... Then you use observations and build some sort of model and then check it against the (new) data.
  45. Tutorial 4: Statistical Theory;Why is the Gaussian Distribution so ...

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/courses/lmb_statistics_course_2014/tutorials/statistical_theory_why_is_the_gaussian_distribution_so_popular.pdf
    20 Mar 2014: 7. Use a ‘for loop’ to iteratively recreate a new random Bin(100, 0.4) sample of100 observations and overplot the corresponding empirical density functionsonto the plot of the Normal density
  46. Tutorial: Introduction to RRob Nicholls – nicholls@mrc-lmb.cam.ac.uk…

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/courses/lmb_statistics_course_2014/tutorials/introduction_to_r.pdf
    6 Mar 2014: 2. Use x, along with mathematical operators, to create a new vector y equivalentto: c(1,4,9). ... Similarly to how sub-vectors may be extracted from vectors, sub-vectors canalso be assigned new values.
  47. Tutorial 2: Descriptive Statisticsand Exploratory Data Analysis Rob…

    https://www2.mrc-lmb.cam.ac.uk/download/tutorial-2-descriptive-statistics/?wpdmdl=18814&refresh=6688095e149511720191326
    6 Mar 2014: hist(rnorm(1000)). would result in histograms being created using new vectors of artificially-generatedrandom Normal data. ... What is the dif-ference between the new and old Spearman correlation coefficients?
  48. Basic principles of probability theory

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/courses/lmb_statistics_course_2014/lectures/Lecture6_linear.ppt
    31 Mar 2014: If observations change (for example few outliers are removed or new observations become available) then AIC should be applied for all models again. ... We can expect that in future when we will have new observations this function will give smallest
  49. Basic principles of probability theory

    https://www2.mrc-lmb.cam.ac.uk/download/lecture-6-linear-regression/?wpdmdl=18812&refresh=6688095f3fce51720191327
    31 Mar 2014: If observations change (for example few outliers are removed or new observations become available) then AIC should be applied for all models again. ... We can expect that in future when we will have new observations this function will give smallest
  50. Tutorial 2: Descriptive Statisticsand Exploratory Data Analysis Rob…

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/courses/lmb_statistics_course_2014/tutorials/descriptive_statistics_and_exploratory_data_analysis.pdf
    6 Mar 2014: hist(rnorm(1000)). would result in histograms being created using new vectors of artificially-generatedrandom Normal data. ... What is the dif-ference between the new and old Spearman correlation coefficients?
  51. Tutorial 6: Linear RegressionRob Nicholls –…

    https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/courses/lmb_statistics_course_2014/tutorials/linear_regression.pdf
    31 Mar 2014: In order to do this, we need tocreate a new variable before attempting to regress y against x1 and x22, e.g.:.

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