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30 Apr 2024: If the pilot experiment raises unexpected new questions, a subsequent pilot experiment will be performed. ... We will routinely check the NC3R's resource library and keep abreast with, and implement where appropriate, any new advances in refinement,

18 Jun 2021: This network will be utilised to maximise the dissemination of the new knowledge gained through this project. ... 3) By generating large quantities of human cells, where appropriate, we can continue to perform new studies using the same human cells.

30 Apr 2024: Therefore there is a clear need to pioneer new medical treatments and technologies to address this increasing disease burden. ... This will inform specific drug projects that are aiming to produce new medicines for patients.

18 Jun 2021: The work will;. 1. Provide new insights into the mechanisms required for regeneration. ... Thus, animal experiments are essential to understand regulatory mechanisms and to design and test potential new therapies.

13 Sep 2021: The research will aid in the development of new bacterial therapies to treat cancer. ... We continuously consider their use and development in light of new experimental data.

29 Apr 2024: This project will develop and test the safety and effectiveness of new vaccines against EHV induced disease. ... Comprehensive details are provided for the new owner and advice given in any areas required.

13 Sep 2021: This second part will provide new hypotheses and research avenues for future research projects about mitochondrial and neurodegenerative diseases. ... Data generated from this project will form the basis for new funding applications, and may eventually

13 Sep 2021: In order to produce new mouse colonies a minority of germ-free mice will be given mammalian gut bacteria orally to produce gnotobiotic mice with a known gut flora (bacteria).

30 Apr 2024: We hope that this will help us develop new treatments for diseases that are caused by problems with myelin. ... Other enrichments like tunnels, climbing structures, and new objects can be added to encourage natural behavior.

30 Apr 2024: We will make a new generation for each line every year (5 generations per line). ... In addition, when generating new genetically modified lines, the F0 embryos need to be genotypically screened.

30 Apr 2024: relevant disease animal models to give us an extra layer of confidence in developing these new medications. ... In all new studies undertaken, the level of insult will be assessed before conducting further studies.

13 Sep 2021: The new insights gained could lead to new strategies for treating such disorders, including learning disabilities and Alzheimer's disease. ... Moreover, our institution's web pages provide regular updates on new developments in the 3Rs.

30 Apr 2024: Any new drug development can take up to 10-12 years before it can be used on human patients. ... We have developed a new method where we can screen antibody secreting B-cells directly for antigen binding.

18 Jun 2021: This project will likely result in new information and publications about the following:. ... In recent years scientists have developed a new way of growing (culturing) cells in 3 dimensions.

18 Jun 2021: tolerance, providing new information on how the genes under investigation impact human metabolism and health. ... or 'negative' in the same way that a trial of a new treatment would be.

29 Apr 2024: Supervisors teaching new PILs will do so following LASA guiding principles to ensure new users are properly trained to perform any procedures necessary. ... Supervisors teaching new licence holders will do so following LASA guiding principles to ensure

19 Aug 2021: The long-term goal of this research is to discover new mechanisms controlling the growth of nerve cells.

13 Sep 2021: Our investigations and the data generated are expected to lead to new collaborations with other researchers. ... We will incorporate new recommendations on animal welfare, as soon as possible after their publication.

18 Jun 2021: We aim to develop new approaches to treatment that target the pathways identified from human genetic studies. ... We will disseminate new knowledge and findings by publishing our results in internationally recognised scientific journals.

30 Apr 2024: In the long-term we hope that this work will lead to translational outputs in the form of clinical trials around new therapeutic agents. ... establishing a new colony of mice from frozen eggs and/or sperm) any further strains of mice we need for this