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20 Aug 2021: Given how little innovation there is in veterinary medicine (compared to human medicine), this new class of drugs could have an even bigger impact on pet health than it did on ... In summary: Short-term benefit – New veterinary medicines based on what

13 Sep 2021: The plan is to generate approximately 10 new models over the course of the licence. ... In this licence we will use lung tumour models to investigate new potential drugs for the treatment of lung cancer.

30 Apr 2024: For example, understanding how cell identity can contribute to diseases may help in the discovery of new treatments. ... I am currently on the European Xenopus Resource Steering Committee where new developments in frog husbandry are often discussed.

19 Aug 2021: These estimates will be updated and recalculated throughout the project as we generate new data.

30 Apr 2024: 1. New mouse models of mitochondrial disease which carry mutations similar to those found in humans. ... The remaining 20% will be neonates (new born pups up to weaning - approx.

8 Jan 2015: The funding bodies encourage researchers to look for opportunities for developing new 3Rs techniques as part of larger programmes of work. ... 21. Communication of advances in the 3RsResearchers should ensure that any new procedures or improvements in

13 Sep 2021: To develop new drugs, it is first necessary to better understand how the nervous system works and what goes wrong in disease: enhanced understanding of how neurones work in health and ... With enhanced knowledge, our work will aid the development of new

13 Sep 2021: For colorectal endoscopic courses, procedures may include a range of new surgical bowel procedures. ... For upper GI endoscopic courses procedures may include tonsillectomy, oesophageal, stomach, duodenal or pancreatic surgery, or other new appropriate

20 Aug 2021: Importantly, we will study the relationship between the hippocampus (the area of the brain which acts as an internal GPS system and is crucial for remembering new events and navigating) and

19 Aug 2021: The treatments that come out of the project may be new intellectual property. ... Altogether, these will generate a blueprint for clinical studies, which will bring successful new treatments to patients.

30 Apr 2024: 6.1 million deaths annually (https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death). ... This is confounded by the fact that there have been very few new antimicrobial products that have been developed over the last 15 years.

30 Apr 2024: We will make a new generation for each line every year (5 generations per line). ... In addition, when generating new genetically modified lines, the F0 embryos need to be genotypically screened.

30 Apr 2024: To the wider pharmaceutical industry and patients this could lead into the development of new anti-cancer therapies. ... Pilot studies are used to establish the correct dose of reagents/cells, timelines, and to generate baseline data for new experiments.

19 Aug 2021: With all this information, new clinical trials can be designed that eventually may change clinical practice. ... They are also required by regulatory authorities before any trials of new drugs can be tested in humans.

29 Apr 2024: This could lead to development of new therapies that are more effective and cause fewer side effects to patients. ... More specifically, we expect to generate at least one new therapy and advance it to a stage that it can be investigated further in large

19 Aug 2021: for pilot studies (https://www.nc3rs.org.uk/conducting-pilot-study);. ARRIVE guidelines, https://www.nc3rs.org.uk/arrive-guidelines;. IMPROVE guidelines for stroke models: ... I receive regular updates via the Biological Service of the University of

30 Apr 2024: To enable us to decide what doses of new treatments we need to use in our respiratory and immunology disease models. ... There are multiple stages of non-animal screening of new molecules that are in place before testing in rodent.

29 Apr 2024: goal by enabling us to test new therapeutic hypothesis in vivo relevant to new treatments for immune mediate diseases. ... This de-risks again the potential for using new therapeutic agents which are unlikely to achieve active concentrations at the

20 Aug 2021: To avoid breeding new mouse strains we will investigate specific immune cells that are labelled.

20 Aug 2021: Page 1 of 8. NON-TECHNICAL SUMMARY. Evaluation of new devices to be used in humansurgery. ... Also, getting new, effective devices/compounds into clinical use as quickly and safely as possible will maximise patient benefits and healthcare savings.