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  2. PPL number: | Granted: 29 Jan 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatment_strategies_for_myocardial_infarction_and_aortic_aneurysm_nts_expires2024_redacted.pdf
    13 Sep 2021: The work will identify exactly how aneurysms develop and new treatments to prevent this. ... culture. Some aspects of disease including assessment of new treatments still require animal studies.
  3. PPL number: | Granted: 04 Apr 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_study_of_epithelial_cancer_genes_nts_expires2022_redacted.pdf
    13 Sep 2021: We will also be studying lung cancer. Nearly 45,000 new cases of lung cancer are diagnosed annually and nearly 35,000 people die from the disease in the UK every ... Our study aims to: 1) Increase the understanding of how types of breast and lung cancers
  4. Placental epignetic programming

    https://www.ubs.admin.cam.ac.uk/system/files/public/placental_epigenetic_programming_non-technical_summary_redacted.pdf
    30 Apr 2024: Our findings will help both clinical and basic science research in reproductive biology and epigenetics to generate new research questions. ... Culture methods for human placental trophoblast cells are very new and still under development.
  5. Early human development and the germline (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/early_human_development_and_the_germline_non-technical_summary_redacted.pdf
    30 Apr 2024: Human embryos are highly inaccessible for research. We use animals to test new experimental approaches, and the knowledge gained can be used to investigate similar events in precious human fetuses and ... We have reduced significantly the number of mice
  6. Cartilage repair and replacement

    https://www.ubs.admin.cam.ac.uk/system/files/public/cartilage_repair_and_replacement_non-technical_summary_redacted.pdf
    29 Apr 2024: Animals will be brought in and allowed to acclimatise for a few weeks - this helps them to relax in their new surroundings, gets them used to the staff and human contact ... bones, which acts as a shock absorber), to which the new implant/therapy will be
  7. New treatments for renal and liver disease (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatments_for_renal_and_liver_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: In work under this licence we aim to identify new treatments for CKD, AKI and NAFLD. ... project? We hope to optimise new imaging efficacy endpoints that will allow assessment of animals over time.
  8. PPL number: | Granted: 05 Oct 17 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/regulation_of_embryonic_lineages_and_stem_cells_nts_expires2022_redacted.pdf
    13 Sep 2021: However, we sometimes need to breed mice carrying particular genetic modifications to provide early embryos for short-term experiments or to generate new stem cell lines. ... Page 4 of 4. means that we require fewer embryo recipient females for creating
  9. PPL number: | Granted: 03 Jul 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/regeneration_in_the_nervous_system_nts_expires2024_redacted.pdf
    13 Sep 2021: Although stem cells in the brain can make new oligodendrocytes that restore myelin, this regenerative process declines with age. ... Our discoveries may be harnessed to develop new regenerative therapies in the treatment of MS.
  10. In vivo compressive forces (non-technical summary)_Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/in_vivo_compressive_forces_non-technical_summary_redacted.pdf
    30 Apr 2024: For each stock a new generation will be grown every 18 months (3.3 generations per line in 5 years). ... For each we will breed a new generation every 18 months (2560x3.3=8448).
  11. PPL number: | Granted: 28 Oct 19 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_how_neutrophil_migration_behaviour_is_fine-tuned_during_inflammation_nts_redacted.pdf
    20 Aug 2021: Work from this licence is likely to unravel new ways to manipulate the behaviour of these cells and inflammatory responses therapeutically. ... The key aspect of our programme is to visualise neutrophil behaviours in situ by advanced microscopy techniques

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