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Two LMB Scientists' archives added to the Wellcome Library - MRC…
https://www2.mrc-lmb.cam.ac.uk/two-lmb-scientists-archives-added-to-the-wellcome-library/28 Jul 2014: The archive papers of two former LMB scientists, John Sulston and Alan Coulson, have been added to the Wellcome Library.
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John Kendrick-Jones and David Komander elected to EMBO membership -…
https://www2.mrc-lmb.cam.ac.uk/john-kendrick-jones-and-david-komander-elected-to-embo-membership/7 May 2014: EMBO elects new members annually on the basis of scientific excellence and outstanding research contributions, and EMBO membership is a lifetime honour. ... More recently, Jake identified a number of new classes of multifunctional myosins that are
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Imaging the Unimaginable: Electron microscopy in the limelight - MRC…
https://www2.mrc-lmb.cam.ac.uk/imaging-the-unimaginable-electron-microscopy-in-the-limelight/25 Jun 2014: The latest advances in electron microscopy at the LMB are featured in MRC’s Network magazine, showing how collaboration and complementary expertise have
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SELPEPCON - an exciting technology platform developed by the LMB’s…
https://www2.mrc-lmb.cam.ac.uk/selpepcon-exciting-technology-platform-developed-lmbs-mike-gait/2 Dec 2014: A technology platform to deliver cargoes using arrays of cell penetrating peptides was developed by the LMB’s Mike Gait, to help treat muscular
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Coupling of transcription termination and mRNA processing - MRC…
https://www2.mrc-lmb.cam.ac.uk/coupling-of-transcription-termination-and-mrna-processing/13 Jan 2014: Work carried out by Lori Passmore’s group in the LMB’s Structural Studies Division, in collaboration with Patrick Cramer’s group in Munich, has revealed
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2013 Francis Crick Lecture to be given by Stanley B. Prusiner - MRC…
https://www2.mrc-lmb.cam.ac.uk/2014-francis-crick-lecture-to-be-given-by-stanley-b-prusiner/4 Apr 2014: Stanley received the Nobel Prize for Physiology or Medicine in 1997, “for his discovery of Prions – a new biological principle of infection”.
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How cells adapt proteasome assembly under stress conditions - MRC…
https://www2.mrc-lmb.cam.ac.uk/how-cells-adapt-proteasome-assembly-under-stress-conditions/4 Aug 2014: Research carried out by Anne Bertolotti’s group in the LMB’s Neurobiology Division has identified a novel protein, named Adc17, that acts as an inducible
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LMB's Melina Schuh interviewed in the Journal of Cell Biology -…
https://www2.mrc-lmb.cam.ac.uk/lmbs-melina-schuh-interviewed-in-the-journal-of-cell-biology/2 Apr 2014: Melina Schuh from the LMB's Cell Biology division discusses her work on oocytes in an interview for the Journal of Cell Biology. More...
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Innate Immunity, Autophagy and Ubiquitin
https://www2.mrc-lmb.cam.ac.uk/groups/randow/Innate_Immunity,_Autophagy_and_Ubiquitin.html23 Apr 2014: More recently we identified a ubiquitin-independent function of NDP52. In this new pathway NDP52 binds to Galectin 8, a cytosolic lectin that detects host glycans on vesicles damaged by Salmonella -
2014 Francis Crick Lecture to be given by Stephen J. Elledge - MRC…
https://www2.mrc-lmb.cam.ac.uk/2014-francis-crick-lecture-to-be-given-by-stephen-j-elledge/12 Sep 2014: Stephen J. Elledge, Gregor Mendel Professor of Genetics, Department of Genetics, Harvard Medical School will give the 2014 Francis Crick Lecture on Friday
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LMB and AstraZeneca announce plan to launch joint research fund - MRC …
https://www2.mrc-lmb.cam.ac.uk/lmb-and-astrazeneca-announce-plan-to-launch-joint-research-fund/15 May 2014: The MRC Laboratory of Molecular Biology and AstraZeneca are today announcing a plan for a research fund to facilitate collaboration between LMB and
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mRNA on the move – localisation can affect cell signalling and…
https://www2.mrc-lmb.cam.ac.uk/mrna-on-the-move-localisation-can-affect-cell-signalling-and-regulation/26 Aug 2014: Published on. 26 August, 2014. New research from Madan Babu’s group in the LMB’s Structural Studies Division, in collaboration with Toby Gibson from the European Molecular Biology Laboratory in ... However in some cases, the mRNA molecules that code
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Madan Babu awarded the Protein Society’s 2014 Protein Science Young…
https://www2.mrc-lmb.cam.ac.uk/madan-babu-awarded-the-protein-societys-2014-protein-science-young-investigator-award/20 Feb 2014: Madan Babu, from the LMB’s Structural Studies Division, has been announced as the recipient of the Protein Society’s 2014 Protein Science Young
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Jason Chin discusses synthetic biology on Guardian Science Weekly…
https://www2.mrc-lmb.cam.ac.uk/jason-chin-discusses-synthetic-biology-on-guardian-science-weekly-podcast/14 May 2014: Jason explains his own work in the field and why synthetic forms of DNA are crucial both for furthering our understanding of fundamental biology and for creating a new generation of
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Speaking at the LMB, George Osborne backs science funding for…
https://www2.mrc-lmb.cam.ac.uk/speaking-at-the-lmb-george-osborne-backs-science-funding-for-cambridge/29 Apr 2014: This article is no longer available from the source website: Cambridge News 25 April 2014.
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Scientists map one of most important proteins in life and cancer -…
https://www2.mrc-lmb.cam.ac.uk/scientists-map-one-of-most-important-proteins-in-life-and-cancer/24 Jul 2014: David Barford and his group, at the LMB and at the Institute of Cancer Research in London, have used cryo-EM to reveal the secondary structure of a vital
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refmac 5.8 series
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/refmac/bug_fixes.html6 Aug 2014: R.Nicholls. Map sharpeining. It is more like new feature than a bug. -
Over 50 LMB scientists showcase research at the Cambridge Science…
https://www2.mrc-lmb.cam.ac.uk/over-50-lmb-scientists-showcase-research-at-the-cambridge-science-festival/27 Mar 2014: On Saturday 15 and Sunday 16 March over 50 LMB scientists helped to showcase LMB research during the Cambridge Science Festival. The LMB had three
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Graphene: stronger than steel and now suitable for biological…
https://www2.mrc-lmb.cam.ac.uk/graphene-stronger-than-steel-and-now-suitable-for-biological-electron-microscopy/22 Apr 2014: Chris and Lori made large sheets of graphene using a new custom-made instrument, designed and built here at the LMB. ... They then invented a new way to change the properties of graphene using a hydrogen plasma so they could control how proteins stick to
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Insights into how the Fanconi Anaemia core complex activates DNA…
https://www2.mrc-lmb.cam.ac.uk/insights-into-how-the-fanconi-anaemia-core-complex-activates-dna-repair/6 Jun 2014: Eeson developed a new method of purifying the complex from chicken cells by fusing a tag to one of the FA proteins and using this to ‘fish’ out the entire complex.
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Major synthetic life breakthrough as LMB scientists make the first…
https://www2.mrc-lmb.cam.ac.uk/major-synthetic-life-breakthrough-lmb-scientists-make-first-artificial-enzymes/2 Dec 2014: laboratory. This milestone from Philipp Holliger’s group at the LMB could soon lead to new ways of developing drugs and medical treatments,Primary Sidebar.
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The Chancellor, George Osborne, visits the LMB in his support for…
https://www2.mrc-lmb.cam.ac.uk/the-chancellor-george-osborne-visits-the-lmb-in-his-support-for-science/25 Apr 2014: He confirmed, “we will deliver, over the next 5 years, the biggest sustained programme of investment in new science capital ever”.
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Heptares Therapeutics granted key patents for GPCR-Focused Drug…
https://www2.mrc-lmb.cam.ac.uk/heptares-therapeutics-granted-key-patents-gpcr-focused-drug-discovery-platform/17 Dec 2014: the National Institute of Medical Research (NIMR) to find new medicines targeting GPCRs.
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Unexpected role of Histone H3.3 in replication of damaged DNA - MRC…
https://www2.mrc-lmb.cam.ac.uk/unexpected-role-of-histone-h3-3-in-replication-of-damaged-dna/16 Sep 2014: This new research suggests that DNA is packaged differently after it has been damaged and that using H3.3 in this way may help cells flag regions of the genome harbouring
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Paul Elliott awarded a Biochemical Society 2015 Early Career Research …
https://www2.mrc-lmb.cam.ac.uk/paul-elliott-awarded-a-biochemical-society-2015-early-career-research-award/8 Apr 2014: Paul Elliott, from the LMB’s Protein and Nucleic Acid Chemistry (PNAC) Division, has won the prestigious Biochemical Society Early Career Research Award
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What next after Academia? Three ways to forge a career away from the…
https://www2.mrc-lmb.cam.ac.uk/what-next-after-academia-three-ways-to-forge-a-career-away-from-the-bench/20 Jun 2014: the new Grants Department at the Babraham Institute.
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Breakthrough in structural biology reveals mitochondrial ribosome…
https://www2.mrc-lmb.cam.ac.uk/breakthrough-in-structural-biology-reveals-mitochondrial-ribosome-structure/28 Mar 2014: new proteins into the EM maps and optimise their fit.
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Protein Synthesis Technology developed at the LMB licenced for use in …
https://www2.mrc-lmb.cam.ac.uk/protein-synthesis-technology-developed-at-the-lmb-licenced-for-use-in-drug-discovery/26 Aug 2014: organisms. GOPAL, which stands for Genetically encoded Orthogonal Protection and Activated Ligation, is a new technology that allows cells to produce proteins that can be linked together in a precise way. ... The technology will help produce new protein
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Hugh Pelham discusses research collaboration between LMB and…
https://www2.mrc-lmb.cam.ac.uk/hugh-pelham-discusses-research-collaboration-between-lmb-and-astrazeneca-in-more-depth/20 May 2014: Published on. 20 May, 2014. Mike Scialom talks to Sir Hugh Pelham about why pledge from the MRC LMB and AstraZeneca could mean good news for Cambridge. ... This article is no longer available from the source website: Cambridge News 20 May 2014.
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Shedding light on how mRNA molecules navigate to their destination…
https://www2.mrc-lmb.cam.ac.uk/shedding-light-on-how-mrna-molecules-navigate-to-their-destination-within-the-cell/15 Apr 2014: Published on. 15 April, 2014. Harish Chandra Soundararajan and Simon Bullock from the LMB’s Cell Biology Division have created a new technique for studying how dynein motors move individual mRNA ... In the current study, unprecedented details of this
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1 Clear StrategyTM Screen I MD1-14 A 6 × ...
https://www2.mrc-lmb.cam.ac.uk/screens2/pdf/LMB10.pdf2 Oct 2014: A new set of conditions can easily be achieved by an increase in the salt or PEG concentration, a shift towards one of the two mixed PEGs or even a change ... Anomalous scattering centres The coupling of new crystallization screens with modern methods to -
Prizewinners Trip to the LMB for Stephen Perse Foundation Senior…
https://www2.mrc-lmb.cam.ac.uk/prizewinners-trip-to-the-lmb-for-stephen-perse-foundation-senior-school-pupils/8 Jul 2014: An article from their school newsletter shows the pupils who grew crystals in their Chemistry lessons and won first prize in the Eastern Region Crystal
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ProSMART Tutorial - Part 2a
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/tutorials/prosmart_tutorial/files/part_2a.html14 Apr 2014: Firstly, follow these steps:. Start a new session - close PyMOL, then re-open it. ... Start a new ProSMART CCP4i job, and load 1ryx.pdb and 1ryx_prosmart_refine.pdb as the target and reference structures, respectively. -
The mother’s role in protecting the fetal genome from aldehyde damage …
https://www2.mrc-lmb.cam.ac.uk/the-mothers-role-in-protecting-the-fetal-genome-from-aldehyde-damage-is-revealed/22 Aug 2014: The fact that the mother can protect the genomic integrity of the developing fetus is a new and significant finding.
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ProSMART Tutorial - Part 2b
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/tutorials/prosmart_tutorial/files/part_2b.html14 Apr 2014: Firstly, follow these steps:. Start a new session - close CCP4mg, then re-open it. ... Firstly follow these steps:. Start a new session - close CCP4mg, then re-open it. -
ProSMART Tutorial - Part 1
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/tutorials/prosmart_tutorial/files/part_1.html14 Apr 2014: For our next round of refinement:. Open a new REFMAC5 job in the CCP4i GUI. ... Provide the original 1ryx.mtz structure factor file in the "MTZ in" fields, and provide the new modified model in the "PDB in" field. -
JCSG+ Screen
https://www2.mrc-lmb.cam.ac.uk/screens2/pdf/LMB11.pdf2 Oct 2014: A new set of conditions can easily be achieved by an increase in the salt or PEG concentration, a shift towards one of the two mixed PEGs or even a change ... Anomalous scattering centres The coupling of new crystallization screens with modern methods to -
PowerPoint Presentation
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/Ligand-meeting-July-9.pptx9 Jul 2014: Second option, two candidates. 12. Building the new Dictionary Clustering the data from COD. ... 15. Generator of molecule geometries using the new Dictionary. A “greedy” global optimization scheme. -
refmac keywords
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/refmac/refmac_keywords.html6 Oct 2014: 2) Put zero inside the sphere centred at current atom with new radius. ... n4 - weighting options. New instructions (a little bit more flexible and useful for complex molecules):. -
7 NOVEMBER 2014 • VOL 346 ISSUE 6210 7 ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/90_Shao_S_Science_2014.pdf8 Nov 2014: that benefit from bacteria. Validation of. this promising new cell culture model for. ... The power of quantitative proteomics may. well shift how new biological pathways are. -
Madeline A. Lancaster Culturing feeder-free human ES cells Modified…
https://www2.mrc-lmb.cam.ac.uk/groups/lancaster/download/Culturing-feeder-free-human-ES-cells.docx21 Mar 2014: 2. Prepare new Matrigel plates as above or warm pre-prepared Matrigel coated dishes in the incubator. ... Add additional media needed. c. Generally minimize pipetting! 8. Transfer 0.5 ml cells per new well and place back in the incubator, being careful -
Onl_Er_embj_201488930_GA 1..3
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/86_Hegde_RS_EMBO_2014.pdf10 Jun 2014: The new studies focus on tail-anchored. (TA) membrane proteins, defined topologi-. -
PowerPoint Presentation
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/ImaginingTheBrain/2014/media/Food_For_Thought.pptx30 Apr 2014: Amino acids to make new proteins and neurotransmitters. Vitamins to carry out essential processes, especially B vitamins, and to act as antioxidants (E & C). -
MinCD cell division proteins form alternating copolymeric cytomotive…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/ncomms6341.pdf6 Dec 2014: analyses, we show that MinD activates MinC by forming a new class of alternating. ... We combined our new crystalstructure with the EcMinD dimer structure, revealing twointeresting features (Fig. -
Madeline A. Lancaster Culturing feeder-dependent human iPS/ES cells…
https://www2.mrc-lmb.cam.ac.uk/groups/lancaster/download/Culturing-human-ES-and-iPS-cells.docx21 Mar 2014: Add 1 ml hES media to well. 10. Resuspend hiPSC pellet in 1 ml hES media per new well of 6-well plate and triturate gently with P1000 tip to get ... 7. Wash the old well with another 1 ml hES media and transfer to new well. -
Word macros that will translate a highlighted area of ...
https://www2.mrc-lmb.cam.ac.uk/groups/cartera/download/resources/computer/word_macros/TranslateIncNucleotide2.docx4 Feb 2014: Selection.Font.Name = "Courier New". Selection.Font.Size = 8. Selection.TypeText (output). -
pone.0107211 1..10
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/leoa2014.pdf3 Sep 2014: LeoA, B and C from Enterotoxigenic Escherichia coli(ETEC) Are Bacterial DynaminsKatharine A. Michie1.¤a, Anders Boysen2., Harry H. Low1.¤b, Jakob Møller-Jensen2, Jan Löwe1. 1 MRC Laboratory of Molecular Biology, Structural Studies Division, -
DOI: 10.1126/science.1256917, 963 (2014);346 Science et al.Thomas G.…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Science-2014-Gligoris-963-7.pdf21 Nov 2014: The title. CopyrightAmerican Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. ... Cross-linking cohesin containing cysteinesat all three interfaces generated a new formform (Ci) whose electrophoretic mobility -
INVITED REVIEW Mechanosensory molecules and circuits in C. elegans ...
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-2.pdf10 Dec 2014: INVITED REVIEW. Mechanosensory molecules and circuits in C. elegans. William R. Schafer. Received: 3 June 2014 /Revised: 30 June 2014 /Accepted: 2 July 2014 /Published online: 23 July 2014# The Author(s) 2014. This article is published with open -
Tutorial 4: Statistical Theory;Why is the Gaussian Distribution so ...
https://www2.mrc-lmb.cam.ac.uk/download/tutorial-4-statistical-theory/?wpdmdl=18816&refresh=6688095ec58ab172019132620 Mar 2014: 7. Use a ‘for loop’ to iteratively recreate a new random Bin(100, 0.4) sample of100 observations and overplot the corresponding empirical density functionsonto the plot of the Normal density
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