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7 Dec 2022: receive prior to taking over the Licence. • The recommendation that if there is any intention to hold animals on the Licence before the new.

23 Feb 2023: Expected duration of the project (Please note for projects or requests for materials that extend beyond 12 months a new non-regulated teaching application will be required every 12 months).

20 Aug 2021: Longer-term benefits will be opportunities for making new treatments for controlling fertility in humans.

19 Aug 2021: Understanding the mechanisms that control killing by these cells will improve the design of new immunotherapies. ... We will provide new information on pathways that are required by killer cells of the immune system.

12 Nov 2021: For example, we realise that we must not be complacent and therefore will actively promote, investigate and use new methods of research that can replace animals and only ever use animals

29 Apr 2024: What's the aim of this project? The overall aim of the research is to develop new and improved vaccines. ... New vaccines need to be safe, well tolerated, effective and offer broad coverage against many pathogens.

13 Sep 2021: Longer-term benefits will be opportunities for making new treatments for controlling fertility in humans.

18 Aug 2015: 16. Slide 16: Why replace animals? - Scientific advantages: New technology can be exploited. ... The development of new technologies opens up opportunities for expanding or improvingresearch in a variety of ways.

30 Apr 2024: Our plan is to publish research papers with new information on which human diseases involve programmed axon death and which specific people are most at risk. ... As we have shown, when a new 3Rs method becomes available (e.g., hiPSC-derived neurons), we

19 Aug 2021: It also allows for the initial testing of new treatment compounds to assess their compatibility. ... This enables the brain to make new circuits to bypass the damaged neurons.

13 Sep 2021: The work will identify exactly how aneurysms develop and new treatments to prevent this. ... culture. Some aspects of disease including assessment of new treatments still require animal studies.

13 Sep 2021: We will also be studying lung cancer. Nearly 45,000 new cases of lung cancer are diagnosed annually and nearly 35,000 people die from the disease in the UK every ... Our study aims to: 1) Increase the understanding of how types of breast and lung cancers

30 Apr 2024: Our findings will help both clinical and basic science research in reproductive biology and epigenetics to generate new research questions. ... Culture methods for human placental trophoblast cells are very new and still under development.

30 Apr 2024: Human embryos are highly inaccessible for research. We use animals to test new experimental approaches, and the knowledge gained can be used to investigate similar events in precious human fetuses and ... We have reduced significantly the number of mice

29 Apr 2024: Animals will be brought in and allowed to acclimatise for a few weeks - this helps them to relax in their new surroundings, gets them used to the staff and human contact ... bones, which acts as a shock absorber), to which the new implant/therapy will be

30 Apr 2024: In work under this licence we aim to identify new treatments for CKD, AKI and NAFLD. ... project? We hope to optimise new imaging efficacy endpoints that will allow assessment of animals over time.

13 Sep 2021: However, we sometimes need to breed mice carrying particular genetic modifications to provide early embryos for short-term experiments or to generate new stem cell lines. ... Page 4 of 4. means that we require fewer embryo recipient females for creating

23 Feb 2023: Expected duration of the project (Please note for projects or requests for materials that extend beyond 12 months a new application will be required every 12 months).

13 Sep 2021: Although stem cells in the brain can make new oligodendrocytes that restore myelin, this regenerative process declines with age. ... Our discoveries may be harnessed to develop new regenerative therapies in the treatment of MS.

30 Apr 2024: For each stock a new generation will be grown every 18 months (3.3 generations per line in 5 years). ... For each we will breed a new generation every 18 months (2560x3.3=8448).

20 Aug 2021: Work from this licence is likely to unravel new ways to manipulate the behaviour of these cells and inflammatory responses therapeutically. ... The key aspect of our programme is to visualise neutrophil behaviours in situ by advanced microscopy techniques

18 Jun 2021: This may be in the form of a new vaccine strategy, or a new anti-viral drug. ... Furthermore, to determine how effective new vaccine approaches are, experimental infections in mice are required.

13 Sep 2021: What's the aim of this project? After food consumption the gut sends signals to the rest of the body preparing it for the arrival of new nutrients. ... We constantly review the literature whilst planning our experiments and acclimatize animals to new

25 Sep 2015: whilst recognising the need to use animals in biomedical research, the development of new medicines. ... welfare. The Home Office Inspectorate is responsible for:.  Processing applications for new licences and certificates.

13 Sep 2021: Our research aims to understand the bases of these disorders, and develop new treatments for them. ... We also aim to use these models to develop new and better treatments for mental health disorders.

20 Aug 2021: Given how little innovation there is in veterinary medicine (compared to human medicine), this new class of drugs could have an even bigger impact on pet health than it did on ... In summary: Short-term benefit – New veterinary medicines based on what

20 Aug 2021: There is a pressing clinical need to identify new types of treatment for human disease (for example, the development of novel antibiotics) and engineered antibodies have considerable potential for this.

8 Jan 2015: The funding bodies encourage researchers to look for opportunities for developing new 3Rs techniques as part of larger programmes of work. ... 21. Communication of advances in the 3RsResearchers should ensure that any new procedures or improvements in

30 Apr 2024: 1. New mouse models of mitochondrial disease which carry mutations similar to those found in humans. ... The remaining 20% will be neonates (new born pups up to weaning - approx.

30 Apr 2024: For example, understanding how cell identity can contribute to diseases may help in the discovery of new treatments. ... I am currently on the European Xenopus Resource Steering Committee where new developments in frog husbandry are often discussed.

13 Sep 2021: Our research will study how and where the bacteria hide in the body to resist to vaccines and antibiotics and will test new innovative vaccines. ... impact of medical treatments and new vaccines on the behaviour of bacteria in an environment that closely

13 Sep 2021: The plan is to generate approximately 10 new models over the course of the licence. ... In this licence we will use lung tumour models to investigate new potential drugs for the treatment of lung cancer.

30 Apr 2024: 6.1 million deaths annually (https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death). ... This is confounded by the fact that there have been very few new antimicrobial products that have been developed over the last 15 years.

30 Apr 2024: We will make a new generation for each line every year (5 generations per line). ... In addition, when generating new genetically modified lines, the F0 embryos need to be genotypically screened.

13 Sep 2021: For colorectal endoscopic courses, procedures may include a range of new surgical bowel procedures. ... For upper GI endoscopic courses procedures may include tonsillectomy, oesophageal, stomach, duodenal or pancreatic surgery, or other new appropriate

19 Aug 2021: The treatments that come out of the project may be new intellectual property. ... Altogether, these will generate a blueprint for clinical studies, which will bring successful new treatments to patients.

13 Sep 2021: To develop new drugs, it is first necessary to better understand how the nervous system works and what goes wrong in disease: enhanced understanding of how neurones work in health and ... With enhanced knowledge, our work will aid the development of new

19 Aug 2021: With all this information, new clinical trials can be designed that eventually may change clinical practice. ... They are also required by regulatory authorities before any trials of new drugs can be tested in humans.

30 Apr 2024: To the wider pharmaceutical industry and patients this could lead into the development of new anti-cancer therapies. ... Pilot studies are used to establish the correct dose of reagents/cells, timelines, and to generate baseline data for new experiments.

19 Aug 2021: for pilot studies (https://www.nc3rs.org.uk/conducting-pilot-study);. ARRIVE guidelines, https://www.nc3rs.org.uk/arrive-guidelines;. IMPROVE guidelines for stroke models: ... I receive regular updates via the Biological Service of the University of

29 Apr 2024: This could lead to development of new therapies that are more effective and cause fewer side effects to patients. ... More specifically, we expect to generate at least one new therapy and advance it to a stage that it can be investigated further in large

19 Aug 2021: These estimates will be updated and recalculated throughout the project as we generate new data.

30 Apr 2024: To enable us to decide what doses of new treatments we need to use in our respiratory and immunology disease models. ... There are multiple stages of non-animal screening of new molecules that are in place before testing in rodent.

20 Aug 2021: Page 1 of 8. NON-TECHNICAL SUMMARY. Evaluation of new devices to be used in humansurgery. ... Also, getting new, effective devices/compounds into clinical use as quickly and safely as possible will maximise patient benefits and healthcare savings.

29 Apr 2024: goal by enabling us to test new therapeutic hypothesis in vivo relevant to new treatments for immune mediate diseases. ... This de-risks again the potential for using new therapeutic agents which are unlikely to achieve active concentrations at the

30 Apr 2024: benefit people living with mental health disorders through the development of new treatments. ... We also expect, in the medium term, that our research will lead to the development of new behavioural treatments.

20 Aug 2021: Importantly, we will study the relationship between the hippocampus (the area of the brain which acts as an internal GPS system and is crucial for remembering new events and navigating) and

30 Apr 2024: There is no cure for neurodegenerative disorders and thus, finding a new common target is at utmost importance. ... We have created new mouse lines with specific mutations in genes that disrupt one of the stress response pathway that is called

29 Apr 2024: Discoveries made on new bacterial species will be published and available to other researchers. ... We continuously consider their use and development in light of new experimental data.

30 Apr 2024: Some of these methods are aimed at providing information to develop new therapies for these diseases. ... We are developing new ways to image cancer and inflammation and find novel ways of treating these diseases.