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MD1-91, MD1-92 and MD1-92-FX Morpheus II 10 mL, HT-96 and FX-96…
https://www2.mrc-lmb.cam.ac.uk/screens2/pdf/LMB20.pdf9 Jul 2018: Some additives such as metal divalent cations can induce new crystal contacts. ... New polyols included for cryoprotection of conditions: no need to investigate more conditions for cryo-cooling. • -
emulator as well as a solid understanding of its ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Traub&Wendland2010.pdf1 Jun 2010: This brings the system into a new interacting ground state. c, The new ground state is characterized by identifying the state of the individual ions. ... discover novel quantum phenomena, identify new quantum phases or just design interest-ing quantum -
www.landesbioscience.com Autophagy 805 Autophagy 6:6, 805-807; August …
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/20574157.pdf2 Aug 2010: Further devel-opment of inhibitors guided by struc-tures could lead to a new generation of improved inhibitors with applications as chemical tools to investigate PtdIns(3)P-dependendent pathways and -
www.sciencemag.org SCIENCE VOL 303 23 JANUARY 2004 479 One ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/BARPerspective.pdf2 Feb 2004: www.sciencemag.org SCIENCE VOL 303 23 JANUARY 2004 479. One of the basic needs of any growingcell is the ability to remodel the lipidmembranes that both surround the. cell and make up its intracellular organelles.At any point in time, a multitude of -
7 NOVEMBER 2014 • VOL 346 ISSUE 6210 7 ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/90_Shao_S_Science_2014.pdf8 Nov 2014: that benefit from bacteria. Validation of. this promising new cell culture model for. ... The power of quantitative proteomics may. well shift how new biological pathways are. -
1 CURRICULUM VITAE Venki Ramakrishnan Nationality U.S. (since 1985)…
https://www2.mrc-lmb.cam.ac.uk/groups/ribo/download/ramakrishnan_cv_4.pdf4 Jan 2024: 2014). A new system for naming ribosomal proteins. Curr Opin Struct Biol 24C, 165-169. ... coli. In Neutrons in Biology (B.P. Schoenborn, ed.), pp 73-92, Plenum Press, New York. -
Supplementary data 15 4 10
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/emboj201099s1.pdf15 Apr 2010: 2008. A novel component of the division-site selection system of Bacillus subtilis and a new mode of action for the division inhibitor MinCD. -
Technician Commitment Evaluating Impact through Self-Assessment & …
https://www2.mrc-lmb.cam.ac.uk/wordpress/?wpdmdl=35486&ind=168994162466726 Jul 2023: example on the intranet or through the TC. newsletter or external news stories. ... input. 2) One external news story. highlighting direct technical. input into a recent. -
ligand-fitting-tutorial.dvi
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/tutorial/ligand-fitting-tutorial.pdf24 Oct 2017: The centre of the screen is a bit crowded now. Undisplay those new ligands. ... When we are happy with our fit, we can merge this new ligand into the mainprotein ligand as we did before. -
Name: than you think! SafetyOur worms, and the bacteria ...
https://www2.mrc-lmb.cam.ac.uk/groups/worms/download/Worms-are-Cleverer-workbook.pdf18 Jan 2018: For example, we can introduce new DNA (i.e. make transgenic animals), to express fluorescent proteins in our cells of interest, or we can silence genes to find out what they -
Model-Building with Modern Coot Paul Emsley Scripps, Feb 2019 ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/Coot-Scripps-Feb-2019-EOS.pdf21 Feb 2019: Less stable More interesting Not always clear how to use the new functions. ... or that the new functions are there). A New Branch. New multi-threaded sections: Refinement. – -
Coot: Model-building tools for Molecular Graphics
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/coot-cshl-2018.pdf24 Oct 2018: 4 PHE Rotamers. Previous. TraditionalBackrub. Helix-Building. Alpha Helix Placement. Scenario: Looking at a new map, not built with automatic tools: “I can see that there’s a helix here - ... Chemical Features. GUI Updates. Map Properties. The New -
Structure of a cholinergic cell membraneNigel Unwina,1 Edited by ...
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/pnasS22.pdf4 Nov 2022: Science175, 720–731 (1972). 2. R. B. Gennis, Biomembranes: Molecular Structure and Function (Springer-Verlag New York Inc.,1989). ... Nat. New Biol. 236,11–12 (1972). 4. D. Branton, Fracture faces of frozen membranes. -
cell4855sup
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/cell%202009%20dynamin%20supp.pdf20 Nov 2009: A new GTPase dimer was created by superimposing the BDLP domain onto the hGBP1 dimer (Ghosh et al., 2006) (see Fig. -
doi:10.1016/j.cub.2004.02.060
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Zimmerberg_McLaughlin2004.pdf17 Mar 2004: An important new structure suggests the BAR domainis a membrane-binding module that can both produceand sense membrane curvature. ... 2Department of Physiology and Biophysics, Health ScienceCenter, State University of New York at Stony Brook, StonyBrook, -
Coot Tools for Cryo-EM Paul EmsleyMRC Laboratory of Molecular ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/coot-cryoEM-2018-Oct-TF.pdf8 Oct 2018: Outline. New Tools for Cryo-EM reconstructions Context (experiments) Large-scale movement (morph and jiggle) Alpha Helix fitting Restraints Refinement Back-rub Rotamers cis-peptides Filaments New visualizations. ... Hydrogen Density? New/Bleeding -
Using Coot for model building into EM maps:A tutorial ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/EM-Tutorial-Coot-PE.pdf8 Sep 2015: Each new top score is highlighted () and the coordinates are updated to the final highest score. -
Onl_Er_embj_201488930_GA 1..3
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/86_Hegde_RS_EMBO_2014.pdf10 Jun 2014: The new studies focus on tail-anchored. (TA) membrane proteins, defined topologi-. -
file:///Users/flong/workplace/balbes_web/MRC-LMB/Webpage/content/balbe…
https://www2.mrc-lmb.cam.ac.uk/groups/murshudov/content/balbes/documentation_fs/manual_115.pdf9 Feb 2012: Install BALBES under CCP4 Package (replace a old version with a new one). ... Close the old xterms and open new ones. Re-start ccp4i and select BALBES. -
KENDREW LECTURE(Part 1) Demis HassabisFounder & CEO DeepMind,…
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/www2.mrc-lmb.cam.ac.uk/?wpdmdl=2135527 Sep 2021: Using AI to accelerate scientific discoveryWednesday 13th October @ 2.30 pmDetails on the LMB website https://www2.mrc-lmb.cam.ac.uk/news-and-events/scientific-seminars/. -
KENDREW LECTURE(Part 2) Wednesday 13th October @ 4.00 pmDetails ...
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/www2.mrc-lmb.cam.ac.uk/?wpdmdl=2135627 Sep 2021: KENDREW LECTURE(Part 2). Wednesday 13th October @ 4.00 pmDetails on the LMB website https://www2.mrc-lmb.cam.ac.uk/news-and-events/scientific-seminars/. -
Nature © Macmillan Publishers Ltd 1998 8 30. Fan, ...
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/FtsZ.Nature.pdf9 Jan 1998: We were not able to detect largeconformational changes between new and old crystals but themolecule may be fixed in one state by crystal restraints. ... J. Appl. Cryst. 11,268–272 (1978). 27. Brünger, A. X-PLOR Version 3.1, A System for X-ray -
tutorial-embo.dvi
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/tutorial-embo.pdf8 Sep 2015: Coot displays a Map Colour Selection window]. • Choose a new colour by clicking on the colour widgets. ... Coot adds intermediate white atoms and pops up a dialog]. • Accept the new atoms. -
tutorial.dvi
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/tutorial.pdf21 Jan 2010: Coot adds intermediate white atoms and pops up a dialog]. • Accept the new atoms. ... 15. • Now optimize the fit of this new residue with Real Space Refinement. -
Setting the stage: development of sample holders for electron ...
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/www2.mrc-lmb.cam.ac.uk/?wpdmdl=2129521 Jun 2021: Also, parts can move during specimen translation, making a new contact with small temperature differences between the contacting parts. ... 1996 Bob Morrison of Gatan Inc., designed a holder for a new Phillips prototype to be used with liquid helium. -
doi:10.1016/j.jbbm.2005.12.008
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/rfcloning2006%20published.pdf19 Apr 2006: 2 min per kb of new construct). ... Of course other ways of eliminating the parentalvector from the new product could be used, such as those described by Refs. -
©2009 EuropEan MolEcular Biology organization EMBo reports Vol 10 ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/MittalEmbor2008240.pdf9 Dec 2008: the Vps26 domain is present in all eukaryotes—which is good news for plants because they were hitherto thought to completely lack arrestins. ... Trends Biochem Sci 28: 598–603. lefkowitz rJ, rajagopal K, Whalen EJ (2006) new roles for β-arrestins in -
Human embryo research information
https://www2.mrc-lmb.cam.ac.uk/groups/shahbazi/wp-content/uploads/sites/30/Human-embryo-research-information.pdf22 Feb 2022: at the cellular level in the laboratory and potentially develop new drug treatments. ... Growing human embryos in a new culture system that permits correct development beyond implantation and up to day 13 of development1. -
Fei Long MRC Laboratory of Molecular Biology, Cambridge, U.K. ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/Ligand_meeting_Sept_29_2017.pdf29 Sep 2017: new_atom_id _chem_mod_atom.new_type_symbol _chem_mod_atom.new_type_energy _chem_mod_atom.new_charge TMPmod1 delete H2. ... chem_mod_bond.new_type _chem_mod_bond.new_value_dist _chem_mod_bond.new_value_dist_esd TMPmod1 delete C1 H2 single. -
Influence of lipid bilayer on the structure of the muscle-type…
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/pnasS24.pdf30 Apr 2024: J. Comput. Chem. 25, 1605–1612 (2004). 38. W. L. Delano, The PyMOL Graphics System (Version 2.0, Schrödinger, LLC, New York, NY, 2017).39. -
DOI: 10.1126/science.1164346 , 509 (2009); 323Science et al.Jeanne…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Salje%20et%20al%20Science%202009.pdf23 Jan 2009: The title. CopyrightAmerican Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. ... 2Department of Biochemistryand Molecular Biophysics, Columbia University, and HowardHughes Medical Institute, New York, NY 10032, -
Science Magazine
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Salje%20et%20al%20Science%202009%20N&V.pdf23 Jan 2009: Unfortunately, although these advances. have opened a completely new window into. ... These findings point the way toward new. questions and opportunities. It is unclear, for. -
53091 361..366
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/McMahonE.pdf3 Dec 2004: Theformation of a new vesicle is thought to be driven by both thepolymerization of the coat protein clathrin into a cage-like structureand the selection/modification of membrane lipids5,6. ... solved in the absence of a lipid head group14 (Fig. 2a, -
Coot Updates Paul EmsleySept 2016 Coot 0.8.4 Released● Patterson ...
https://www2.mrc-lmb.cam.ac.uk/coot/ligands/2016/emsley-ccp4-ligand-meeting-sept-2016-v5.pdf28 Sep 2016: Lidia Improved letter placement. Old Coot New Coot RDKit. Coot Updates 0.8.7: Lidia. ... Given a ligand SMILES, how do I find out to which ligand (about which the PDB already knows) it is most similar?– Change the atom names of my new ligand to -
Coot: Model-building tools for Molecular Graphics
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/bgu/coot-2018-bgu.pdf22 Feb 2018: 4 PHE Rotamers. Previous. TraditionalBackrub. Helix-Building. Alpha Helix Placement. Scenario: Looking at a new map, not built with automatic tools: “I can see that there’s a helix here - ... Why are they different? or new NCS Differences graph. -
� Supplementary Figure 1 Bacterial dynamin-like protein (BDLP) from…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/nature%20BDLP%202006%20sup.pdf28 Sep 2006: 3L). 29. Krissinel, E. & Henrick, K. Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. -
mbar-v2
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/mbar-v2.pdf31 Aug 2018: proceed. 2.2.3.The new waters have been added to chain D, and it is important to inspect them and make sure that they have all been added in appropriate -
Coot Tools for Cryo-EM Paul EmsleyMRC Laboratory of Molecular ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/coot-cryoEM-2018-Aug-Stockholm.pdf15 Aug 2018: Lots to see at 4 rmsd. Alpha Helix Placement. Scenario: Looking at a new map, not built with automatic tools: “I can see that there’s a helix here - build ... New/Bleeding Edge/Still-in-Development. The New Ramachandran Plot. EMD-0144:1.65 Å -
Paul EmsleyMRC Laboratory of Molecular Biology, Cambridge, UKJune…
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/Ligands-July-2015-v2.pdf16 Jul 2015: wwPDB Ligands. Year on year increase in the number of new entities. ... 6943 new ligand types (88%) are non-polymers. – LINKed ligands excluded. -
3919Commentary Introduction Kinesin motors use energy supplied by ATP …
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/JCScommentary.pdf31 Oct 2007: 1) The tethered, ADP-bound lead head is free to find a new binding site. ... N., Muller,J. and Mandelkow, E. (2000). A new look at the microtubule binding patterns ofdimeric kinesins. -
CURRICULUM VITAE
https://www2.mrc-lmb.cam.ac.uk/groups/bienz/wp-content/uploads/sites/23/BienzCV_March2024.pdf11 Apr 2024: signalling. EMBO J 18, 1630-1641. 60. Yu X, Waltzer L & Bienz M (1999) A new Drosophila APC homologue associated with. ... Science 316, 1619-1622. 93. Tran H, Hamada F, Schwarz-Romond T & Bienz M (2008) Trabid, a new positive regulator of. -
doi:10.1016/j.cell.2008.11.004
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/55_Kang_SW_Cell_2008.pdf21 Nov 2008: redox perturbations), thereby providing a new tool for exploring the ER. ... This new molecular tool can now be combined with the vast collections of yeast strains (deletion, hypomorphic, overexpression, and other mutations) to reveal previously -
LETTERS A bacterial dynamin-like proteinHarry H. Low1 & Jan ...
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/nature%20BDLP%202006.pdf28 Nov 2006: S. & Vallee, R. B.Molecular cloning of the microtubule-associated mechanochemical enzymedynamin reveals homology with a new family of GTP-binding proteins. -
nature structural biology . volume 5 number 6 . june 1998
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/nsb1998.pdf14 Jan 2002: Lloyd, C.W. Microtubules (Wiley-Liss, New York, 1993). 2. 3m. 4C. ... Hol, W.G. Crystal structure of glycosomal glyceraldehyde-3-. phosphate dehydrogenase from Leishmania mexicana: implications for structure-based drug design and new position for the -
7400749.qxd
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/41_Ashok_A_EMBORep_2006.pdf19 Jun 2006: Intriguing new studiesindicate a potentially key role for MVB pathways in prion transmis-sion and metabolism, reinforcing the central importance of proteintransport pathways as the molecular basis of various diseases. ... Validation of thisprovocative -
73687_Trans
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/emboj201099s2.pdf28 Apr 2010: There are still questions about how the structure recognizes the very slight curvature of the polar membrane, but the new structural information greatly advances the discussion. -
Jason William Chin Page 1 of 18 MRC Laboratory ...
https://www2.mrc-lmb.cam.ac.uk/ccsb/wp-content/uploads/2024/01/Chin-cv-26012024.pdf29 Jan 2024: 2008. 4: 232-234. [Featured in Nature 2008. 45: 868, Chemistry & Engineering News (ACS). ... 2006. 2: 254-258. [News & Views, Nature Chem. Biol. 2006. 2: 231-232]. -
Crystal Screen Lite™ is a complete reagent kit designed ...
https://www2.mrc-lmb.cam.ac.uk/screens2/pdf/LMB06b.pdf26 Jun 2015: Discard the pipet tip, add a new pipet tip and pipet 1 ml of Crystal Screen Lite reagent 2 into reservoir A2. -
MinCD cell division proteins form alternating copolymeric cytomotive…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/ncomms6341.pdf6 Dec 2014: analyses, we show that MinD activates MinC by forming a new class of alternating. ... We combined our new crystalstructure with the EcMinD dimer structure, revealing twointeresting features (Fig. -
rq5005
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/iucrjS20.pdf28 Jul 2020: L. D. & Kirshner, D. A. (1971). Nature New Biol. 231,.
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