Search

5 Jan 2016: F.Z. is supported by the National Institutesof Health through NIMH (5DP1-MH100706 and 1R01MH110049)and NIDDK (5R01DK097768-03), a Waterman Award from theNational Science Foundation, the Keck, New York Stem ... Metcalfe. F.Z. is a New York Stem Cell

28 Nov 2008: context of our findings, study of Cla-thrin-independent endocytic pathways will reveal new layersof complexity underlying lipid and protein cargo selection, ap-propriate intracellular trafficking of endocytic membranes, andthe mechanisms

23 Nov 2004: W, FxDxF, WVxF and a new FxxFxxL motif), we can now. ... but a number of new ligands including the HIV-1 Rev inter-.

23 Jul 2007: andImmunology, Weill Medical College of Cornell University, New York,NY, USA.

20 Apr 2002: Phosphoinositide-Specific Phospholipase Cδ1 Activity toward Micellar Substrates,Inositol 1,2-Cyclic Phosphate, and Other Water-Soluble Substrates: A Sequential. Mechanism and Allosteric Activation†. Yiqin Wu,‡ Olga Perisic, Roger L. Williams,

3 May 2011: Neurotransmitters arereleased into the synaptic cleft and bind to postsynaptic receptors to activate/modulate its activity.Vesicle components and membrane are recycled by endocytosis either directly to form new synapticvesicles or

24 Jan 2009: Molecular Biology of the CellVol. 19, 5093–5103, December 2008. Synaptotagmin-1 Utilizes Membrane Bending and SNAREBinding to Drive Fusion Pore ExpansionKara L. Lynch, Roy R.L. Gerona, Dana M. Kielar, Sascha Martens,†Harvey T. McMahon,† and

19 Nov 2019: H. W. Scheres, New tools for automated high-resolution cryo-EM structure determination in RELION-3.

3 Feb 1998: CtmPrP and human neurodegenerativedisease. Given that the distribution of new-ly synthesized PrP between transmembraneand secretory topologic forms is readily ma-. ... A new paradigm for PrP-induced neu-rodegeneration. Our studies were motivatedby the

27 Oct 2003: 2003). GRIP domain-mediated targeting of two new coiled-coilof the ARF GTPases.

15 Aug 2007: The unfolded protein re-sponse (UPR) consists principally of two broad strategies fordealing with ER stress: increased clearance of misfoldedproteins from the ER lumen and reduction of new proteininflux into the ... This phosphor-ylation leads to rapid

29 Aug 2021: Q5 High-Fidelity 2X Master Mix (New England Biolabs,. Ipswich, MA, USA) as per manufacturer’s instructions.

31 Aug 2006: PLoS BIOLOGY. Figure 1. New Protein Interaction Partners for the a- and b-Appendage Domains of AP2 Adaptors(A) Plot of the network of protein interactions in clathrin-mediated endocytosis. ... Two Interaction Sites for New Motifs on the b-AppendageProtein

30 May 2008: Supporting Information Available: Detailed experimental section,synthesis, and spectral characterization of new compounds.

1 Dec 2010: The EMBO Journal, (2010). doi:10.1038/emboj.2010.315

4 Mar 2019: Hiraga, S. The new gene mukB. codes for a 177 kd protein with coiled-coil domains involved in chromosome partitioning of E.

24 Jan 2002: Developmental Cell, Vol. 2, 207–217, February, 2002, Copyright  2002 by Cell Press. Signal Sequences Control Gatingof the Protein Translocation Channelin a Substrate-Specific Manner. lumenal side, the permeability barrier of the ER mem-brane

22 Jul 2008: Although the study of essential and constitutive facets of translocation has required simple and highly robust model systems, the study of regulation will probably necessitate more complex substrates and potentially new

31 Dec 2014: eLife digest Cell division is the process by which new cells are made. ... In the long run, intricate knowledge of how a bacterial cell divides might enable the design of new classes of antibiotics targeting the molecular machinery involved.DOI:

18 Feb 2016: 5a,b) has led to new insights that might hold the key to understanding this stress response.

14 Dec 2010: predicted gene products on chromosome one, we attempt to find new molecules that. ... To. this end, the worm has proven invaluable in the identification of new molecules.

19 Jan 2017: PURE system translation reactions. Initial experiments used the PURE translation system from New England Biolabs as per the manufacturer’s instructions.

4 Oct 2010: Roles of Amphipathic Helices and the Bin/Amphiphysin/Rvs(BAR) Domain of Endophilin in Membrane CurvatureGenerationSReceived for publication, March 26, 2010, and in revised form, April 16, 2010 Published, JBC Papers in Press, April 23, 2010, DOI

13 Dec 2008: The Hydrophobic Insertion Mechanism of Membrane CurvatureGeneration by Proteins. Felix Campelo,y Harvey T. McMahon,z and Michael M. KozlovDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv,

18 Apr 2006: Discovery of new ESCRT-I-interacting part-. ners, such as AIP/ALIX, which binds directly to ESCRT-.

28 May 2013: Kevin Cowtan, cowtan@ysbl.york.ac.uk 2012. ParrotSummary:A new classical density modification program,. employing the latest techniques. ... Kevin Cowtan, cowtan@ysbl.york.ac.uk 2012. Nautilus: A new tool for nucleic acid model building Automated (CCP4i)

14 Jun 2007: Several previously unsuspected key links between multiple ESCRT subunits, phospholipids and ubiquitin have now been elucidated, which, together with the detailed morphological analyses of ESCRT-depletion phenotypes, provide new insights into

3 Aug 2009: Subsequently, Get3 revertstowards the open dimer state, lowering its affinity for the Get1/2receptor, and returning it to the cytosol to initiate a new round oftargeting. ... PHENIX: building new software for automated crystallographicstructure

15 Jul 2005: Cotransin thus provides a powerful new probefor investigating the molecular function of a protein-conductingchannel as well as a selective, reversible method of inhibitingcotranslational translocation in living cells.

3 Sep 2008: to prepare grids for EM analysis. If no filaments were visible in this initial examination, the protein stock was incubated at 4C for 3–4 days and new EM.

16 Jul 2008: more generally, led to new insights into the deter-minants for QC of GPI-anchored proteins in the ER. ... All enzymes for cloning were ob-tained from New England Biolabs (Beverly, MA) with the exception of Pfupolymerase, which was from Stratagene (La

15 May 2007: 1Institut Cochin, Université Paris Descartes, CNRS(UMR 8104), Paris, France2INSERM, U567, 75014 Paris, France3MRC Laboratory of Molecular Biology, Cambridge,CB2 2QH, UK4The Laboratory of Cellular Biophysics, The RockefellerUniversity, New York, NY

15 Jan 2004: Therefore, we employed two new ap-proaches. First, we took advantage of the ability of PTA todifferentially precipitate PrPSc while leaving PrPC in the super-natant fraction. ... ity of this model system, until now. Selective precipitation ofPrPSc(P101L)

15 Feb 2007: Biochim Biophys Acta 1711:33–40. 7. Haigh NG, Johnson AE (2002) A new role for BiP: closing theaqueous translocon pore during protein integration into the ERmembrane.

29 Dec 2004: G., eds) Vol. 17, pp. 312-362, Academic Press, New York. Beam, K.

17 Aug 2006: TIBS-432; No of Pages 9. Review TRENDS in Biochemical Sciences Vol.xxx No.x. The surprising complexity of signalsequencesRamanujan S. Hegde1 and Harris D. Bernstein2. 1 Cell Biology and Metabolism Branch, National Institute of Child Health and Human

18 Jan 2019: RESEARCH ARTICLE. The ER membrane protein complex promotes biogenesis ofsterol-related enzymes maintaining cholesterol homeostasisNorbert Volkmar1,, Maria-Laetitia Thezenas2, Sharon M. Louie3, Szymon Juszkiewicz4, Daniel K. Nomura3,Ramanujan S.

10 Jun 2008: suggested that goa-1 defined a new pathway, independent of the ones activated by flp-1 and.

22 May 2008: These blebs are reversible, and re-versal requires actin polymerization into thesesites to provide new membrane-cytoskeletonlinkage. ... Upon recovery fromhypotonic stretch, cells shrink and new invagi-nations from the membrane are formed (133).The

27 Jan 2018: Constructs for translation in the PURE system (28) were based on the T7-based PURExpress plasmid provided by New England Biolabs.

31 Jul 2019: Biochemistry 2019.58:3144-3154

24 Sep 2015: An ER Complex of ODR-4 and ODR-8/Ufm1 SpecificProtease 2 Promotes GPCR Maturation by a Ufm1-Independent MechanismChangchun Chen, Eisuke Itakura, Katherine P. Weber, Ramanujan S. Hegde, Mario de Bono. MRC Laboratory of Molecular Biology, Cambridge,

30 May 2008: Asymmetric distribution of pause transfer sequences in apolipoprotein B-I00. Maryann H. Kivlen, Cynthia A. Dorsey, Vishwanath R. Lingappa,'yt and Ramanujan S. Hegde Departments of Physiology and Medicine, University. of California, San Francisco,

28 Feb 1998: Cell, Vol. 92, 621–631, March 6, 1998, Copyright 1998 by Cell Press. TRAM Regulates the Exposure of Nascent SecretoryProteins to the Cytosol during Translocationinto the Endoplasmic Reticulum. In addition to transport across the membrane, a vari

9 Sep 2015: Cotransin appears to trap the new protein chain within the Sec61 channel by essentially ‘locking’ the side-gate. ... By preventing the plug from moving out of the way, cotransin can somehow stop the new protein from passing through the side-gate.

15 Sep 2011: James E. ROTHMAN (New Haven, U.S.A.) The mechanism of control of neurotransmitter release Le mécanisme de contrôle de la libération des neurotransmetteurs. - ... challenged. My presntation will highlight and disccuss the new findings regrading the

22 Jul 2008: The new structure in-. dicates that a single copy of Sec61 is bound to the nontranslating. ... plexes bound to ribosomes. The TRAP ComplexOur new structure shows that one copy of the TRAP complex is.

16 Feb 2010: To maximize the severity of the phenotype (if any) caused by CtmPrP, the new.

31 Oct 2005: This explanation would necessitate additional protein complexes that facilitate this reor-ganization and new mechanisms to solve the permeability problem. ... systems. On the other hand is the equally powerful feature ofevolution to forge new biological

16 Nov 2011: Discovery of a new insertion pathwayAs the SRPdependent pathway was being elucidated, it became clear that at least some membrane proteins might not be able to use this route for insertion. ... After release from Get1, what prevents Get3–ATP from