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  2. Insight 1 Dec McMahon NS

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/NatureReview2005.pdf
    4 Jan 2006: Curvature modules within proteins are conjugated withother protein motifs and domains, and from these collaborativeactivities we can suggest some new ideas for how membrane curva-ture can be generated by multiple ... This proposal that amphipathic
  3. INVITED REVIEW Mechanosensory molecules and circuits in C. elegans ...

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-2.pdf
    10 Dec 2014: INVITED REVIEW. Mechanosensory molecules and circuits in C. elegans. William R. Schafer. Received: 3 June 2014 /Revised: 30 June 2014 /Accepted: 2 July 2014 /Published online: 23 July 2014# The Author(s) 2014. This article is published with open
  4. Monitoring chaperone engagement of substratesin the endoplasmic…

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/39_Snapp_EL_PNAS_2006.pdf
    21 Sep 2006: Thus, inhibitingglucosidases with castanospermine (Cst) will prevent new glycop-roteins from interacting with lectin chaperones (20) and maintainthe association between the lectin chaperones and already mono-glucosylated substrates (37) (Fig.
  5. cdf672 6935..6943

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/ParM%20EMBO%20F-actin%202002.pdf
    30 Dec 2002: However, new dataon the rapid and direct translocation of newly replicatedplasmids and origins of replication on bacterial chromo-somes suggest a force-generating process (Niki andHiraga, 1998; Jensen and Shapiro, 1999; ... Theaddition of new subunits to
  6. 14821680963433 1..18

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/e21600-download.pdf
    19 Dec 2016: panel). In this new position, the loop interacts extensively with subunits of the opposite strand (Fig-. ... to add a stop codon after residue E167 using Q5 site directed mutagenesis (New England Biolabs,.
  7. N402_18f 313..320

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/10580505.pdf
    11 Nov 1999: G. Analysing Survival Data from Clinical Trials and Observational Studies. (Wiley, New York, 1995). ... Autophosphorylation of p110d phosphoinositide 3-kinase: a new paradigm. for the regulation of lipid kinases in vitro and in vivo.
  8. doi:10.1016/j.molcel.2006.06.019

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Ftsk%20mc%202006.pdf
    12 Aug 2006: Molecular Cell 23, 457–469, August 18, 2006 ª2006 Elsevier Inc. DOI 10.1016/j.molcel.2006.06.019. Double-Stranded DNA Translocation:Structure and Mechanism of Hexameric FtsK. Thomas H. Massey,2,3 Christopher P. Mercogliano,1,3. James Yates,2
  9. Clay_thesis

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/AnthonyKempf.pdf
    4 Oct 2005: 1. CHAPTER I: INTRODUCTION. Attempting to deduce the molecular and cellular basis of certain behaviors in higher. organisms such as vertebrates can be a daunting task due to the sheer complexity of neuronal. circuits in these organisms. However,
  10. LETTERS Structural basis for selective recognition of ESCRT-IIIby the …

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17928861.pdf
    8 Dec 2007: 2Department of Molecular Biology and Genetics and Institute for Cell andMolecular Biology, Biotechnology Building, Cornell University, Ithaca, New York 14853, USA.
  11. httDownloaded from rsif.royalsocietypublishing.org ResearchCite this…

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-1.pdf
    4 Feb 2015: New York, NY 10032, USA.}Present address: Department of Biochemistry. and Biophysics, University of California,. ... New York, NY 10010, USA. Electronic supplementary material is available. at http://dx.doi.org/10.1098/rsif.2014.0963 or.
  12. doi:10.1016/j.molcel.2004.08.030

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Haering%20Mol%20Cell%202004.pdf
    20 Sep 2004: anaphase. as synchronously as cells that had expressed it only new bridges at any period from the completion of DNA. ... dissocia-ates new links between sister chromatids.tion of Smc1 and Smc3 hinge domains or when Smc1and Smc3 heads are not connected by
  13. Cell, Vol. 91, 575–582, November 28, 1997, Copyright 1997 ...

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/9_Hegde_RS_Cell_1997.pdf
    20 Nov 1997: 1980). The immunoglobulin m chains ofa new site of regulation in the cell. ... 1992). Oligosaccharyl-strates, will surely elucidate new functions for old ma- transferase activity is associated with a protein complex composed.
  14. Structural analysis of the ParR/parC plasmidpartition complex Jakob…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/MollerJensen_ParR_EMMBO_2007.pdf
    4 Oct 2007: model of ParM-mediated plasmid partition that takes the new. ParR structure into account. ... T, Warren GL (1998) Crystallography &NMR system: a new software suite for macromolecular structuredetermination.
  15. npgrj_nchembio_117 691..699

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/18849971.pdf
    16 Oct 2008: Throughiterative chemical synthesis, X-ray crystallography and kinome-level biochemical profiling, we identified compounds that inhibit aspectrum of new target combinations in these two families. ... The progress of this chemistry. was guided by testing
  16. Reconstitution of a prokaryotic minus end-trackingsystem using TubRC…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/PNAS-2015-Fink-E1845-50.pdf
    27 Apr 2015: Clearly, new TubZ monomers incorporated only at thefilament ends that were free of TubRC (Fig. ... pH 7.5), 500 mM KCl, 10 mM EDTA, 0.5 mM TCEP] by chitin-affinity chromatography (New England Biolabs).
  17. A-nsmb855.indd

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/nsmb%20FtsZ%202004.pdf
    19 Nov 2004: 39. Brunger, A.T. et al. Crystallography & NMR system: a new software suite for macromo-lecular structure determination.
  18. Structural and Membrane Binding Analysis of the PhoxHomology Domain…

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17581820.pdf
    8 Dec 2007: Fatty acid-free bovine serum albumin was from Bayer(Kankakee, IL). Restriction endonucleases and other enzymesfor molecular biology were from New England Biolabs (Beverly,MA). ... Bem1p-PX, but alsothe mechanism by which this PX domain interacts
  19. PII: S0304-3991(97)00070-3

    https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/ultram97.pdf
    4 Apr 2003: parameters. Clearly there may be some advantage in repeating the overall procedure using the distortion-corrected structure as a new reference. ... The new values of. Y and w are used to re-extract the Fourier terms along the layer-lines, and then z.
  20. The structure of human thyroglobulin

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/TG_Nature2020.pdf
    31 Jan 2020: Struct. Biol. 180, 519–530 (2012). 35. Zivanov, J. et al. New tools for automated high-resolution cryo-EM structure determination in RELION-3.
  21. d402_16g 822..826

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/15_Hegde_RS_Nature_1999.pdf
    9 Dec 1999: The framework described in Fig. 5 proposes several new areas forfuture studies. ... encephalopathies. New Eng. J. Med. 399, 19942004 (1998). 4. Horwich, A.
  22. THE JOURNAL OF BIOLOGICAL CHEMISTRY 0 1990 by The ...

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/1_Pewitt_EB_JBC_1990a.pdf
    29 Dec 2004: In addition, little new information regarding cotransport regulation in avian erythrocytes can come from this approach. ... Unlabeled bume- tanide and furosemide was the gift of Hoechst Pharmaceuticals (New Jersey).
  23. Molecular Biology of the CellVol. 8, 2003–2015, October 1997 ...

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/WiggeKohler_McMahon1997.pdf
    10 Oct 1997: 1997). The SH3 domain of amphiphysinbinds the proline-rich domain of dynamin at a single site thatdefines a new SH3 binding consensus sequence.
  24. x96255u149

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/11090628.pdf
    20 Apr 2002: Pannu, N.S., et al. (1998). Crystallography & NMR system: a new Meggio, F., Donella-Deana, A., Ruzzene, M., Brunati, A.M., Cesaro,software suite for macromolecular structure determination. ... 1996).Norman, B.H., Shih, C., Toth, J.E., Ray, J.E., Dodge,
  25. Dynamic Filaments of the Bacterial Cytoskeleton

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/annrev2006.pdf
    19 Apr 2006: 476Actin. 476ParM. 477MreB. 479FtsA. 482. INTERMEDIATE FILAMENTHOMOLOGUE. 483Crescentin. 483. WALKER A CYTOSKELETALATPASE—A NEW FAMILY OFCYTOSKELETAL PROTEINS? ... New subunits assemble at the pre-ferred end, and after nucleotide hydrolysis
  26. Structural insight into the ESCRT-I/-II link and itsrole in ...

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17215868.pdf
    14 Jun 2007: We also show that a new component of. ESCRT-I, Mvb12 (YGR206W), engages ESCRT-I directly. ... ESCRT-I binds directly to a new subunit, Mvb12,. forming a stable 1:1:1:1 heterotetrameric complex.
  27. PII: S0962-8924(99)01504-4

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/14_Hegde_RS_TCB_1999.pdf
    11 Mar 1999: Withthe recent progress in understanding some of theconstitutive aspects of protein biogenesis andtranslocation, the time has come to develop new as-says and investigate more diverse and challengingsubstrates.
  28. 088542u047

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Owen_McMahon1999.pdf
    17 Mar 2003: and. therefore soluble protein (see Experimental Procedures). a-adaptin appendage domain revealed a single candi-date protein-binding site centered around W840 andA new longer construct comprising residues 695–938,. ... Warrington,a new clathrin
  29. The EMBO Journal Vol.17 No.18 pp.5273–5285, 1998 Crystal structure ...

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Owen_McMahon1998.pdf
    9 Sep 1998: We had previously suggestedthat the Amph2 binding site on dynamin might showdifferent peptide-binding characteristics from that ofAmph1 (Wiggeet al., 1997a) but the new data demonstratethat the two isoforms do, in
  30. No Job Name

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/vandenent2008ftsq.pdf
    4 Mar 2008: Structural and mutational analysis of the cell divisionprotein FtsQ. Fusinita van den Ent,1 Thessa M. F. Vinkenvleugel,2. Alice Ind,1 Philip West,1 Dmitry Veprintsev,1. Nanne Nanninga,2 Tanneke den Blaauwen2 andJan Löwe11MRC-LMB, Hills Road,
  31. TH EJ OU RN AL OF CE LL BIO ...

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16785321.pdf
    12 Nov 2006: The Saccharomyces cerevisiae centrin, Cdc31p, binds Sfi 1p on multiple conserved repeats; both proteins localize to the SPB half-bridge, where the new SPB is assembled. ... Again, these SPBs show a bimodal distribution of stain, peaking close to the edge
  32. Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and…

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-4.pdf
    30 Jun 2015: RESEARCH ARTICLE. Sensory Neurons Arouse C. elegansLocomotion via Both Glutamate andNeuropeptide ReleaseSeungwon Choi1,2,3, Kelsey P. Taylor1,2,3, Marios Chatzigeorgiou4, Zhitao Hu1,2,William R. Schafer4, Joshua M. Kaplan1,2,3. 1 Department of
  33. Four-stranded mini microtubules formed by Prosthecobacter BtubAB show …

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/PNAS-2017-Deng-E5950-8.pdf
    29 Dec 2017: dejongeii DSM 12251 (PdBtubAB), a stop codon (TAA)was introduced before the C-terminal hexahistidine tag in the BtubAB bacterialT7 expression plasmid used (7) by Q5 mutagenesis (New England Biolabs). ... E5954 |
  34. Amphiphysin is necessaryfor organization of the…

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/DroxAmph.pdf
    9 Nov 2001: The phenotypesof mice deficient in amphiphysin 2 should help clarifythis question.In conclusion, our results shed new light on the role of.
  35. 3747_0_supp_7_1052456676

    https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/christian.pdf
    9 May 2003: sensors and cultured neurons are useful new tools for studying protein function in.
  36. A Ternary Metal Binding Site in the C2 Domain ...

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/9062102.pdf
    20 Apr 2002: PIP2, phosphatidylinositol4,5-bisphosphate; PI-PLC, phosphoinositide-specific phospholipase C;cPKC, “conventional” protein kinase C (Ca2+ dependent); nPKC, “new”protein kinase C (Ca2+ independent); rmsd, root mean square standarddeviation;
  37. Crystal Structures of Bacillus subtilis Lon Protease

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/londumanjmb2010.pdf
    20 Jul 2010: Journal of Molecular Biology, doi:10.1016/j.jmb.2010.06.030
  38. pnas201205508 15259..15264

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/22949682.pdf
    25 Nov 2012: The synergy of p110αmutants could form the basis for a new class of resistant mutations.The increased affinity of the oncogenic mutants for lipid.
  39. Crystal Structure of a Calcium-Phospholipid Binding Domainfrom…

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/9430701.pdf
    20 Apr 2002: Properties, Columbia University, New York73. Pearson, R. H., and Pascher, I.
  40. IntroductionThe endosomal system functions as an internal…

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/SNX2Cullen2005.pdf
    17 Jan 2006: and Cullen, P. J. (2005).Sorting nexins – Unifying trends and new perspectives.
  41. doi:10.1016/j.coph.2005.03.002

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/15963759.pdf
    12 Nov 2006: www.sciencedirect.com. Rodriguez-Borlado L, Calvo V et al.: Identification andcharacterization of a new oncogene derived from theregulatory subunit of phosphoinositide 3-kinase.
  42. Mechanism of ribosome stalling during translation of a poly(A) tail

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/NSMB_2019.pdf
    25 Nov 2019: R., Mohr, S. C. & Smith, T. F. Genomic detection of new yeast pre-mRNA 3’-end-processing signals.
  43. 80096 RPF

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/EMBO2012FtsAPiotr/emboj201276s3.pdf
    7 Mar 2012: In conclusion, our new data does not provide any insight into this phenomenon. ... We really hope this is clear now – we are certainly very happy with the new data.
  44. GB-9-7-229-Amos_9.qxd

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/gb-2008-9-7-229.pdf
    4 Aug 2008: tubules with the aid of new microtubule-associated proteins. (MAPs), some of which may be related to tektins [49,50]. ... has grown longer through gene duplication. It is likely that many such questions will be answered as new.
  45. doi:10.1016/j.molcel.2008.05.027

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/FtsK%20MolCell%202008%20Lowe.pdf
    16 Aug 2008: The new. high-resolution structure confirms that FtsKg is a winged helix. ... conformation, though the new high-resolution crystal structure. shows that the two strands do not have a regular b sheet hydro-.
  46. CAN-11-2008 3642..3651

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/79_Basseville_A_CanRes_2012.pdf
    24 Sep 2015: treatment leads to improvement of ABCG2 mutant trafficking.We first determined whether the increased ABCG2 expressionon the cell surface required new protein synthesis. ... Here, we highlighted a new molecularmechanism, HDIs acting as modulators of
  47. PII: S0969-2126(02)00801-8

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Kent_McMahonOwen2002.pdf
    30 Jul 2002: The ear of alpha-adaptin interacts with theand R.M. Sweet, eds. (New York: Academic Press), pp.
  48. doi:10.1016/j.tibs.2009.03.001

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/58_Chakrabarti_O_TIBS_2009.pdf
    13 Jun 2009: Recent advances in our understanding of normalPrP biosynthesis and degradation might have unexpect-edly shed new light on this complex problem. ... Cell 93, 337–3484 Wickner, R.B. et al. (2004) Prion genetics: new rules for a new kind of.
  49. Bacterial chromosome segregation: structure andDNA binding of the Soj …

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/soj_embo2005.pdf
    30 Jan 2005: Bacterial chromosome segregation: structure andDNA binding of the Soj dimer — a conservedbiological switch. Thomas A Leonard, P Jonathan Butlerand Jan Löwe. MRC Laboratory of Molecular Biology, Cambridge, UK. Soj and Spo0J of the Gram-negative
  50. Nicotinic Acetylcholine Receptor at 4.6 Å Resolution: Transverse…

    https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/jmb99.pdf
    15 Sep 2003: A description of the main new features beginswith the cation-conducting pathway.
  51. Tumour prevention by a single antibody domaintargeting the…

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17568777.pdf
    22 Jul 2007: trates a capacity for small proteins to target the ‘undruggable’. protein interaction surface, presenting a new spectrum of. ... Springer: New York, USA. CCP4 (1994) The CCP4 suite: programs for protein crystallography.Acta Crystallogr D 50: 760–763

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