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Insight 1 Dec McMahon NS
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/NatureReview2005.pdf4 Jan 2006: Curvature modules within proteins are conjugated withother protein motifs and domains, and from these collaborativeactivities we can suggest some new ideas for how membrane curva-ture can be generated by multiple ... This proposal that amphipathic -
INVITED REVIEW Mechanosensory molecules and circuits in C. elegans ...
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-2.pdf10 Dec 2014: INVITED REVIEW. Mechanosensory molecules and circuits in C. elegans. William R. Schafer. Received: 3 June 2014 /Revised: 30 June 2014 /Accepted: 2 July 2014 /Published online: 23 July 2014# The Author(s) 2014. This article is published with open -
Monitoring chaperone engagement of substratesin the endoplasmic…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/39_Snapp_EL_PNAS_2006.pdf21 Sep 2006: Thus, inhibitingglucosidases with castanospermine (Cst) will prevent new glycop-roteins from interacting with lectin chaperones (20) and maintainthe association between the lectin chaperones and already mono-glucosylated substrates (37) (Fig. -
cdf672 6935..6943
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/ParM%20EMBO%20F-actin%202002.pdf30 Dec 2002: However, new dataon the rapid and direct translocation of newly replicatedplasmids and origins of replication on bacterial chromo-somes suggest a force-generating process (Niki andHiraga, 1998; Jensen and Shapiro, 1999; ... Theaddition of new subunits to -
14821680963433 1..18
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/e21600-download.pdf19 Dec 2016: panel). In this new position, the loop interacts extensively with subunits of the opposite strand (Fig-. ... to add a stop codon after residue E167 using Q5 site directed mutagenesis (New England Biolabs,. -
N402_18f 313..320
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/10580505.pdf11 Nov 1999: G. Analysing Survival Data from Clinical Trials and Observational Studies. (Wiley, New York, 1995). ... Autophosphorylation of p110d phosphoinositide 3-kinase: a new paradigm. for the regulation of lipid kinases in vitro and in vivo. -
doi:10.1016/j.molcel.2006.06.019
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Ftsk%20mc%202006.pdf12 Aug 2006: Molecular Cell 23, 457–469, August 18, 2006 ª2006 Elsevier Inc. DOI 10.1016/j.molcel.2006.06.019. Double-Stranded DNA Translocation:Structure and Mechanism of Hexameric FtsK. Thomas H. Massey,2,3 Christopher P. Mercogliano,1,3. James Yates,2 -
Clay_thesis
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/AnthonyKempf.pdf4 Oct 2005: 1. CHAPTER I: INTRODUCTION. Attempting to deduce the molecular and cellular basis of certain behaviors in higher. organisms such as vertebrates can be a daunting task due to the sheer complexity of neuronal. circuits in these organisms. However, -
LETTERS Structural basis for selective recognition of ESCRT-IIIby the …
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17928861.pdf8 Dec 2007: 2Department of Molecular Biology and Genetics and Institute for Cell andMolecular Biology, Biotechnology Building, Cornell University, Ithaca, New York 14853, USA. -
httDownloaded from rsif.royalsocietypublishing.org ResearchCite this…
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-1.pdf4 Feb 2015: New York, NY 10032, USA.}Present address: Department of Biochemistry. and Biophysics, University of California,. ... New York, NY 10010, USA. Electronic supplementary material is available. at http://dx.doi.org/10.1098/rsif.2014.0963 or. -
doi:10.1016/j.molcel.2004.08.030
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Haering%20Mol%20Cell%202004.pdf20 Sep 2004: anaphase. as synchronously as cells that had expressed it only new bridges at any period from the completion of DNA. ... dissocia-ates new links between sister chromatids.tion of Smc1 and Smc3 hinge domains or when Smc1and Smc3 heads are not connected by -
Cell, Vol. 91, 575–582, November 28, 1997, Copyright 1997 ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/9_Hegde_RS_Cell_1997.pdf20 Nov 1997: 1980). The immunoglobulin m chains ofa new site of regulation in the cell. ... 1992). Oligosaccharyl-strates, will surely elucidate new functions for old ma- transferase activity is associated with a protein complex composed. -
Structural analysis of the ParR/parC plasmidpartition complex Jakob…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/MollerJensen_ParR_EMMBO_2007.pdf4 Oct 2007: model of ParM-mediated plasmid partition that takes the new. ParR structure into account. ... T, Warren GL (1998) Crystallography &NMR system: a new software suite for macromolecular structuredetermination. -
npgrj_nchembio_117 691..699
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/18849971.pdf16 Oct 2008: Throughiterative chemical synthesis, X-ray crystallography and kinome-level biochemical profiling, we identified compounds that inhibit aspectrum of new target combinations in these two families. ... The progress of this chemistry. was guided by testing -
Reconstitution of a prokaryotic minus end-trackingsystem using TubRC…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/PNAS-2015-Fink-E1845-50.pdf27 Apr 2015: Clearly, new TubZ monomers incorporated only at thefilament ends that were free of TubRC (Fig. ... pH 7.5), 500 mM KCl, 10 mM EDTA, 0.5 mM TCEP] by chitin-affinity chromatography (New England Biolabs). -
A-nsmb855.indd
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/nsmb%20FtsZ%202004.pdf19 Nov 2004: 39. Brunger, A.T. et al. Crystallography & NMR system: a new software suite for macromo-lecular structure determination. -
Structural and Membrane Binding Analysis of the PhoxHomology Domain…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17581820.pdf8 Dec 2007: Fatty acid-free bovine serum albumin was from Bayer(Kankakee, IL). Restriction endonucleases and other enzymesfor molecular biology were from New England Biolabs (Beverly,MA). ... Bem1p-PX, but alsothe mechanism by which this PX domain interacts -
PII: S0304-3991(97)00070-3
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/ultram97.pdf4 Apr 2003: parameters. Clearly there may be some advantage in repeating the overall procedure using the distortion-corrected structure as a new reference. ... The new values of. Y and w are used to re-extract the Fourier terms along the layer-lines, and then z. -
The structure of human thyroglobulin
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/TG_Nature2020.pdf31 Jan 2020: Struct. Biol. 180, 519–530 (2012). 35. Zivanov, J. et al. New tools for automated high-resolution cryo-EM structure determination in RELION-3. -
d402_16g 822..826
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/15_Hegde_RS_Nature_1999.pdf9 Dec 1999: The framework described in Fig. 5 proposes several new areas forfuture studies. ... encephalopathies. New Eng. J. Med. 399, 19942004 (1998). 4. Horwich, A. -
THE JOURNAL OF BIOLOGICAL CHEMISTRY 0 1990 by The ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/1_Pewitt_EB_JBC_1990a.pdf29 Dec 2004: In addition, little new information regarding cotransport regulation in avian erythrocytes can come from this approach. ... Unlabeled bume- tanide and furosemide was the gift of Hoechst Pharmaceuticals (New Jersey). -
Molecular Biology of the CellVol. 8, 2003–2015, October 1997 ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/WiggeKohler_McMahon1997.pdf10 Oct 1997: 1997). The SH3 domain of amphiphysinbinds the proline-rich domain of dynamin at a single site thatdefines a new SH3 binding consensus sequence. -
x96255u149
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/11090628.pdf20 Apr 2002: Pannu, N.S., et al. (1998). Crystallography & NMR system: a new Meggio, F., Donella-Deana, A., Ruzzene, M., Brunati, A.M., Cesaro,software suite for macromolecular structure determination. ... 1996).Norman, B.H., Shih, C., Toth, J.E., Ray, J.E., Dodge, -
Dynamic Filaments of the Bacterial Cytoskeleton
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/annrev2006.pdf19 Apr 2006: 476Actin. 476ParM. 477MreB. 479FtsA. 482. INTERMEDIATE FILAMENTHOMOLOGUE. 483Crescentin. 483. WALKER A CYTOSKELETALATPASE—A NEW FAMILY OFCYTOSKELETAL PROTEINS? ... New subunits assemble at the pre-ferred end, and after nucleotide hydrolysis -
Structural insight into the ESCRT-I/-II link and itsrole in ...
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17215868.pdf14 Jun 2007: We also show that a new component of. ESCRT-I, Mvb12 (YGR206W), engages ESCRT-I directly. ... ESCRT-I binds directly to a new subunit, Mvb12,. forming a stable 1:1:1:1 heterotetrameric complex. -
PII: S0962-8924(99)01504-4
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/14_Hegde_RS_TCB_1999.pdf11 Mar 1999: Withthe recent progress in understanding some of theconstitutive aspects of protein biogenesis andtranslocation, the time has come to develop new as-says and investigate more diverse and challengingsubstrates. -
088542u047
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Owen_McMahon1999.pdf17 Mar 2003: and. therefore soluble protein (see Experimental Procedures). a-adaptin appendage domain revealed a single candi-date protein-binding site centered around W840 andA new longer construct comprising residues 695–938,. ... Warrington,a new clathrin -
The EMBO Journal Vol.17 No.18 pp.5273–5285, 1998 Crystal structure ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Owen_McMahon1998.pdf9 Sep 1998: We had previously suggestedthat the Amph2 binding site on dynamin might showdifferent peptide-binding characteristics from that ofAmph1 (Wiggeet al., 1997a) but the new data demonstratethat the two isoforms do, in -
No Job Name
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/vandenent2008ftsq.pdf4 Mar 2008: Structural and mutational analysis of the cell divisionprotein FtsQ. Fusinita van den Ent,1 Thessa M. F. Vinkenvleugel,2. Alice Ind,1 Philip West,1 Dmitry Veprintsev,1. Nanne Nanninga,2 Tanneke den Blaauwen2 andJan Löwe11MRC-LMB, Hills Road, -
TH EJ OU RN AL OF CE LL BIO ...
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16785321.pdf12 Nov 2006: The Saccharomyces cerevisiae centrin, Cdc31p, binds Sfi 1p on multiple conserved repeats; both proteins localize to the SPB half-bridge, where the new SPB is assembled. ... Again, these SPBs show a bimodal distribution of stain, peaking close to the edge -
Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and…
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-4.pdf30 Jun 2015: RESEARCH ARTICLE. Sensory Neurons Arouse C. elegansLocomotion via Both Glutamate andNeuropeptide ReleaseSeungwon Choi1,2,3, Kelsey P. Taylor1,2,3, Marios Chatzigeorgiou4, Zhitao Hu1,2,William R. Schafer4, Joshua M. Kaplan1,2,3. 1 Department of -
Four-stranded mini microtubules formed by Prosthecobacter BtubAB show …
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/PNAS-2017-Deng-E5950-8.pdf29 Dec 2017: dejongeii DSM 12251 (PdBtubAB), a stop codon (TAA)was introduced before the C-terminal hexahistidine tag in the BtubAB bacterialT7 expression plasmid used (7) by Q5 mutagenesis (New England Biolabs). ... E5954 | -
Amphiphysin is necessaryfor organization of the…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/DroxAmph.pdf9 Nov 2001: The phenotypesof mice deficient in amphiphysin 2 should help clarifythis question.In conclusion, our results shed new light on the role of. -
3747_0_supp_7_1052456676
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/christian.pdf9 May 2003: sensors and cultured neurons are useful new tools for studying protein function in. -
A Ternary Metal Binding Site in the C2 Domain ...
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/9062102.pdf20 Apr 2002: PIP2, phosphatidylinositol4,5-bisphosphate; PI-PLC, phosphoinositide-specific phospholipase C;cPKC, “conventional” protein kinase C (Ca2+ dependent); nPKC, “new”protein kinase C (Ca2+ independent); rmsd, root mean square standarddeviation; -
Crystal Structures of Bacillus subtilis Lon Protease
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/londumanjmb2010.pdf20 Jul 2010: Journal of Molecular Biology, doi:10.1016/j.jmb.2010.06.030 -
pnas201205508 15259..15264
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/22949682.pdf25 Nov 2012: The synergy of p110αmutants could form the basis for a new class of resistant mutations.The increased affinity of the oncogenic mutants for lipid. -
Crystal Structure of a Calcium-Phospholipid Binding Domainfrom…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/9430701.pdf20 Apr 2002: Properties, Columbia University, New York73. Pearson, R. H., and Pascher, I. -
IntroductionThe endosomal system functions as an internal…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/SNX2Cullen2005.pdf17 Jan 2006: and Cullen, P. J. (2005).Sorting nexins – Unifying trends and new perspectives. -
doi:10.1016/j.coph.2005.03.002
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/15963759.pdf12 Nov 2006: www.sciencedirect.com. Rodriguez-Borlado L, Calvo V et al.: Identification andcharacterization of a new oncogene derived from theregulatory subunit of phosphoinositide 3-kinase. -
Mechanism of ribosome stalling during translation of a poly(A) tail
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/NSMB_2019.pdf25 Nov 2019: R., Mohr, S. C. & Smith, T. F. Genomic detection of new yeast pre-mRNA 3’-end-processing signals. -
80096 RPF
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/EMBO2012FtsAPiotr/emboj201276s3.pdf7 Mar 2012: In conclusion, our new data does not provide any insight into this phenomenon. ... We really hope this is clear now – we are certainly very happy with the new data. -
GB-9-7-229-Amos_9.qxd
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/gb-2008-9-7-229.pdf4 Aug 2008: tubules with the aid of new microtubule-associated proteins. (MAPs), some of which may be related to tektins [49,50]. ... has grown longer through gene duplication. It is likely that many such questions will be answered as new. -
doi:10.1016/j.molcel.2008.05.027
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/FtsK%20MolCell%202008%20Lowe.pdf16 Aug 2008: The new. high-resolution structure confirms that FtsKg is a winged helix. ... conformation, though the new high-resolution crystal structure. shows that the two strands do not have a regular b sheet hydro-. -
CAN-11-2008 3642..3651
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/79_Basseville_A_CanRes_2012.pdf24 Sep 2015: treatment leads to improvement of ABCG2 mutant trafficking.We first determined whether the increased ABCG2 expressionon the cell surface required new protein synthesis. ... Here, we highlighted a new molecularmechanism, HDIs acting as modulators of -
PII: S0969-2126(02)00801-8
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Kent_McMahonOwen2002.pdf30 Jul 2002: The ear of alpha-adaptin interacts with theand R.M. Sweet, eds. (New York: Academic Press), pp. -
doi:10.1016/j.tibs.2009.03.001
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/58_Chakrabarti_O_TIBS_2009.pdf13 Jun 2009: Recent advances in our understanding of normalPrP biosynthesis and degradation might have unexpect-edly shed new light on this complex problem. ... Cell 93, 337–3484 Wickner, R.B. et al. (2004) Prion genetics: new rules for a new kind of. -
Bacterial chromosome segregation: structure andDNA binding of the Soj …
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/soj_embo2005.pdf30 Jan 2005: Bacterial chromosome segregation: structure andDNA binding of the Soj dimer — a conservedbiological switch. Thomas A Leonard, P Jonathan Butlerand Jan Löwe. MRC Laboratory of Molecular Biology, Cambridge, UK. Soj and Spo0J of the Gram-negative -
Nicotinic Acetylcholine Receptor at 4.6 Å Resolution: Transverse…
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/jmb99.pdf15 Sep 2003: A description of the main new features beginswith the cation-conducting pathway. -
Tumour prevention by a single antibody domaintargeting the…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17568777.pdf22 Jul 2007: trates a capacity for small proteins to target the ‘undruggable’. protein interaction surface, presenting a new spectrum of. ... Springer: New York, USA. CCP4 (1994) The CCP4 suite: programs for protein crystallography.Acta Crystallogr D 50: 760–763
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