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20 Aug 2021: Given how little innovation there is in veterinary medicine (compared to human medicine), this new class of drugs could have an even bigger impact on pet health than it did on ... In summary: Short-term benefit – New veterinary medicines based on what

13 Sep 2021: The plan is to generate approximately 10 new models over the course of the licence. ... In this licence we will use lung tumour models to investigate new potential drugs for the treatment of lung cancer.

30 Apr 2024: For example, understanding how cell identity can contribute to diseases may help in the discovery of new treatments. ... I am currently on the European Xenopus Resource Steering Committee where new developments in frog husbandry are often discussed.

19 Aug 2021: These estimates will be updated and recalculated throughout the project as we generate new data.

30 Apr 2024: 1. New mouse models of mitochondrial disease which carry mutations similar to those found in humans. ... The remaining 20% will be neonates (new born pups up to weaning - approx.

8 Jan 2015: The funding bodies encourage researchers to look for opportunities for developing new 3Rs techniques as part of larger programmes of work. ... 21. Communication of advances in the 3RsResearchers should ensure that any new procedures or improvements in

13 Sep 2021: To develop new drugs, it is first necessary to better understand how the nervous system works and what goes wrong in disease: enhanced understanding of how neurones work in health and ... With enhanced knowledge, our work will aid the development of new

13 Sep 2021: For colorectal endoscopic courses, procedures may include a range of new surgical bowel procedures. ... For upper GI endoscopic courses procedures may include tonsillectomy, oesophageal, stomach, duodenal or pancreatic surgery, or other new appropriate

20 Aug 2021: Importantly, we will study the relationship between the hippocampus (the area of the brain which acts as an internal GPS system and is crucial for remembering new events and navigating) and

19 Aug 2021: The treatments that come out of the project may be new intellectual property. ... Altogether, these will generate a blueprint for clinical studies, which will bring successful new treatments to patients.

30 Apr 2024: 6.1 million deaths annually (https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death). ... This is confounded by the fact that there have been very few new antimicrobial products that have been developed over the last 15 years.

30 Apr 2024: We will make a new generation for each line every year (5 generations per line). ... In addition, when generating new genetically modified lines, the F0 embryos need to be genotypically screened.

30 Apr 2024: To the wider pharmaceutical industry and patients this could lead into the development of new anti-cancer therapies. ... Pilot studies are used to establish the correct dose of reagents/cells, timelines, and to generate baseline data for new experiments.

19 Aug 2021: With all this information, new clinical trials can be designed that eventually may change clinical practice. ... They are also required by regulatory authorities before any trials of new drugs can be tested in humans.

29 Apr 2024: This could lead to development of new therapies that are more effective and cause fewer side effects to patients. ... More specifically, we expect to generate at least one new therapy and advance it to a stage that it can be investigated further in large

19 Aug 2021: for pilot studies (https://www.nc3rs.org.uk/conducting-pilot-study);. ARRIVE guidelines, https://www.nc3rs.org.uk/arrive-guidelines;. IMPROVE guidelines for stroke models: ... I receive regular updates via the Biological Service of the University of

30 Apr 2024: To enable us to decide what doses of new treatments we need to use in our respiratory and immunology disease models. ... There are multiple stages of non-animal screening of new molecules that are in place before testing in rodent.

29 Apr 2024: goal by enabling us to test new therapeutic hypothesis in vivo relevant to new treatments for immune mediate diseases. ... This de-risks again the potential for using new therapeutic agents which are unlikely to achieve active concentrations at the

20 Aug 2021: To avoid breeding new mouse strains we will investigate specific immune cells that are labelled.

20 Aug 2021: Page 1 of 8. NON-TECHNICAL SUMMARY. Evaluation of new devices to be used in humansurgery. ... Also, getting new, effective devices/compounds into clinical use as quickly and safely as possible will maximise patient benefits and healthcare savings.

30 Apr 2024: benefit people living with mental health disorders through the development of new treatments. ... We also expect, in the medium term, that our research will lead to the development of new behavioural treatments.

30 Apr 2024: Some of these methods are aimed at providing information to develop new therapies for these diseases. ... We are developing new ways to image cancer and inflammation and find novel ways of treating these diseases.

29 Apr 2024: Discoveries made on new bacterial species will be published and available to other researchers. ... We continuously consider their use and development in light of new experimental data.

30 Apr 2024: Our findings should guide these attempts and clarify the mechanisms of action these new therapies employ. ... When animals are exposed to new diets or environments they receive training sessions.

30 Apr 2024: There is no cure for neurodegenerative disorders and thus, finding a new common target is at utmost importance. ... We have created new mouse lines with specific mutations in genes that disrupt one of the stress response pathway that is called

30 Apr 2024: In the short term, the scientific community will gain new information on the pathways and genes that we will investigate. ... Numbers are being adjusted in Dec 2022 following the obtention of new research funding.

29 Apr 2024: For breeding design we use several online resources, especially when bringing in a new strain. ... care for our strains and to identify any new and better treatments that could be utilised.

29 Apr 2024: The new bedding material generated much less dust. What published best practice guidance will you follow to ensure experiments are conducted inthe most refined way? ... Therefore, the project licence holder will have regular discussions with the Named

30 Apr 2024: This means that others do not need to generate new mutants or samples, minimising animal numbers. ... For any new procedures we will review published protocols from experienced collaborators before conducting any experiments.

30 Apr 2024: In new systems pilot studies are utilised to ensure the system works as intended with a small group (e.g. ... Mice would also be habitualised to a new restraint before, e.g., BP measurement.

30 Apr 2024: until we require new offspring. ... I will also have regular discussions with the Named Persons and animal technicians to review current approaches and whether there are any new 3R opportunities.

30 Apr 2024: These new discoveries will be shared with others at local, national and international scientific meetings and in widely available publications. ... In more detail, it is our expectation that our research will produce one new.

13 Sep 2021: We will perform pilot studies testing any new therapies in very small groups of normal mice. ... These new therapies will have already been tested in isolated cells in the laboratory.

30 Apr 2024: Also, these devices will help us learn more about these diseases and might help find even more new treatments. ... Subscribing to the NC3Rs newsletter (https://www.nc3rs.org.uk/news) to receive regular updates on new ideas and research related to the 3Rs.

19 Aug 2021: We hope this will help find new ways to treat or prevent brain disease. ... However, when we develop new techniques, we carefully consider the literature and seek expert advice before starting.

30 Apr 2024: Both are important immunological processes and targets for the development of new drugs. ... There is a great unmet clinical need in this area and our experiments could inform the development of new therapeutics.

18 Jun 2021: Page 3 of 10. New genes of interest will be identified and described. ... Thus, finding new biomarkers improves our ability to both detect and treat cancer.

19 Aug 2021: These papers will describe the development of a new type of bone repair material. ... the structure may be compromised, while if it too slow it may adversely affect new bone formation.

30 Apr 2024: The treatments that are validated in the project may include new intellectual property. ... Altogether, these will generate a blueprint for clinical studies, which will bring successful new treatments to patients.

19 Aug 2021: basal skin layer, the productive life cycle is triggered and new viruses are produced; iv) PV is shed inside dead cells from the surface of. ... new insight into PV transmission mechanisms, and the development of anti-papillomavirus agents/treatments and

30 Apr 2024: suffer from traumatic brain injuries and 14 million new incidents of stroke globally, each year. ... may require the generation of new transgenic animals, therefore reducing the number of animals needed to fulfil the objectives we set up in this license.

13 Sep 2021: What's the aim of this project? This project aims to discover and develop new ways to treat or prevent malaria transmission and disease. ... As such, the development of new anti-malaria blocking strategies is a major objective.

18 Jun 2021: The new insights gained could lead to new strategies for treating such disorders, including learning disabilities and Alzheimer's disease. ... Moreover, our institution's web pages provide regular updates on new developments in the 3Rs.

30 Apr 2024: Ultimately, the intention is that this research will lead to new treatments being developed for mood, anxiety and stress-related mental health disorders. ... benefit people living with mental health disorders through the development of new treatments.

13 Sep 2021: In order to produce new mouse colonies a minority of germ-free mice will be given mammalian gut bacteria orally to produce gnotobiotic mice with a known gut flora (bacteria).

30 Apr 2024: If the pilot experiment raises unexpected new questions, a subsequent pilot experiment will be performed. ... We will routinely check the NC3R's resource library and keep abreast with, and implement where appropriate, any new advances in refinement,

30 Apr 2024: relevant disease animal models to give us an extra layer of confidence in developing these new medications. ... In all new studies undertaken, the level of insult will be assessed before conducting further studies.

30 Apr 2024: Therefore there is a clear need to pioneer new medical treatments and technologies to address this increasing disease burden. ... This will inform specific drug projects that are aiming to produce new medicines for patients.

18 Jun 2021: This network will be utilised to maximise the dissemination of the new knowledge gained through this project. ... 3) By generating large quantities of human cells, where appropriate, we can continue to perform new studies using the same human cells.

30 Apr 2024: Any new drug development can take up to 10-12 years before it can be used on human patients. ... We have developed a new method where we can screen antibody secreting B-cells directly for antigen binding.