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  2. Mendelian randomization: Old and new insights | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/talk/epfl-2021/
    3 Jun 2024: Search. Mendelian randomization: Old and new insights. Abstract. Mendelian randomization (MR) is a method for causal inference that utilizes the natural experiment in genetic inheritance. ... I will talk about an ongoing work on “almost exact Mendelian
  3. www.statslab.cam.ac.uk/~qz280/tag/genetics/index.xml

    www.statslab.cam.ac.uk/~qz280/tag/genetics/index.xml
    3 Jun 2024: 2021/ Mendelian randomization: Old and new insights https://www.statslab.cam.ac.uk/qz280/talk/penn-biostat-2021/ Fri, 16 Apr 2021 18:00:00 0000 ... uk/qz280/talk/penn-biostat-2021/ Mendelian randomization: Old and new insights
  4. www.statslab.cam.ac.uk/~qz280/talk/index.xml

    www.statslab.cam.ac.uk/~qz280/talk/index.xml
    3 Jun 2024: and new insights https://www.statslab.cam.ac.uk/qz280/talk/penn-biostat-2021/ Fri, 16 Apr 2021 18:00:00 0000 ... biostat-2021/ Mendelian randomization: Old and new insights https://www.statslab.cam.ac.uk/qz280/talk/epfl-2021/ Fri, 26 Mar 2021 15:00:00
  5. Mendelian randomization: Old and new insights | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/talk/penn-biostat-2021/
    3 Jun 2024: Search. Mendelian randomization: Old and new insights. Abstract. Mendelian randomization (MR) is a method for causal inference that utilizes the natural experiment in genetic inheritance. ... I will talk about an ongoing work on “almost exact Mendelian
  6. Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/
    3 Jun 2024: I am interested in improving the general quality and appraisal of statistical research, including new methodology and a better understanding of causal inference, novel study designs, sensitivity analysis, multiple testing, and ... News. <2024-03-01 Fri>
  7. | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/featured/
    3 Jun 2024: September 2023A new approach to sensitivity analysis in linear SEMs using stochastic optimization and the $R2$-calculus.
  8. www.statslab.cam.ac.uk/~qz280/tag/workflow/index.xml

    www.statslab.cam.ac.uk/~qz280/tag/workflow/index.xml
    3 Jun 2024: environment. One of the many outcomes is this new personal website powered by the <a href="https://sourcethemes.com/academic/" target="_blank" rel="noopener">Academic theme</a> for <a ... ac.uk/qz280/news/">news</a> to make announcements and display new
  9. Macros for graph separations | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/post/graph-separation/
    3 Jun 2024: We invented some new notation to distinguish some different types of graph connections/separations. ... Macros for the new notation can be found in the file below:.
  10. PathGPS: Discover shared genetic architecture using biobank data |…

    https://www.statslab.cam.ac.uk/~qz280/publication/pathgps/
    3 Jun 2024: May 2022Abstract. The increasing availability and scale of Genome Wide Association Studies (GWAS) bring new horizons for understanding biological mechanisms. ... When applying to a metabolomics dataset and the UK Biobank, PathGPS confirms several known
  11. Posts | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/post/
    3 Jun 2024: We invented some new notation to distinguish some different types of graph connections/separations.
  12. Genetics | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/tag/genetics/
    3 Jun 2024: The idea of MR can be traced back to the dawn of modern statistics and genetics a century ago, although the terminology was not …. Mendelian randomization: Old and new insights.
  13. Probability and Random Processes, 4e

    www.statslab.cam.ac.uk/~grg/books/prp5.html
    3 May 2024: What's new in this pair of volumes? Reorganization and expansion of certain material. ... Addition of around 300 new exercises and problems, making a total of over 1300.
  14. Resarch Group in Mathematical Statistics Department of Pure…

    www.statslab.cam.ac.uk/~nickl/Site/ercproject.html
    7 Feb 2024: NEW: Conference for Vladimir Koltchinskii. NEW: Workshop in September 2024 in Cambridge.
  15. IV & MR (project page) | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/project/iv-mr/
    3 Jun 2024: A new Bayesian full-information method for life-course Mendelian randomization. Zixuan Wu, Ethan Lewis, Qingyuan Zhao, Jingshu Wang. ... The new GRAPPLE framework can handle multiple exposures and overlapping exposure and …. Jingshu Wang, Qingyuan Zhao,
  16. MR Data Challenge 2019 — The role of lipoprotein subfractions in…

    www.statslab.cam.ac.uk/~qz280/talk/mr-raps-markdown/report.pdf
    3 Jun 2024: 2017. “Association Analyses Based on False Discovery Rate Implicate New Loci forCoronary Artery Disease.” Nature Genetics 49 (9): 1385.
  17. 2-nhb.dvi

    www.statslab.cam.ac.uk/~grg/books/hammfest/2-nhb.pdf
    22 Mar 2024: Academic Press, New York.Zeller, K. and Beekmann, W. (1970). Theorie der Limitierungsverfahren. ... Springer-Verlag, Berlin. Department of MathematicsRoyal Holloway and Bedford New CollegeEgham HillEghamSurrey TW20 0EX.
  18. Two high-profile examples of selection bias Qingyuan Zhao Statistical …

    www.statslab.cam.ac.uk/~qz280/talk/uw-csss-2022/slides.pdf
    3 Jun 2024: Common mistake: New data Existing model = Wrong results. Qingyuan Zhao (Stats Lab, Cambridge) Two high-profile examples of selection bias May 11, 2022 3 / 29.
  19. Using sparsity to overcome unmeasured confounding:Two parametric…

    www.statslab.cam.ac.uk/~qz280/talk/iscb-2020/slides.pdf
    3 Jun 2024: Qingyuan Zhao (Stats Lab) Specificity/Sparsity ISCB 2020 24 / 27. New MR results.
  20. 1 May 2024: On 17 August 2007 they had their first experience of owner-occupancyon moving into their new home in Charlbury Road. ... 13 (1985), 1279–1285. [31] N. Madras and G. Slade, The Self-Avoiding Walk, Birkhäuser/Springer, New York,2013.
  21. How infectious was COVID-19 when it first circulated in Wuhan?

    www.statslab.cam.ac.uk/~qz280/talk/corpus-masterclass-2022/slides.pdf
    3 Jun 2024: Li, et al. New England Journal of Medicine.I Published online: Jan 29, 2020I Estimated initial doubling time: 7.4 days (95% CI, 4.2 to 14);I Estimated R0: ... Two initial studies. 1 Q. Li, et al. New England Journal of Medicine.I Published online: Jan 29,
  22. Causal Inference: An Introduction Qingyuan Zhao Statistical…

    www.statslab.cam.ac.uk/~qz280/talk/ssrmp-2020/slides.pdf
    3 Jun 2024: Bad news: What’s in this lecture may not reflect the current practice ofcausal inference in social sciences. ... Further readingsBook-long treatments (from less mathematical to most mathematical):. Mackenzie and Pearl (2018) The Book of Why: The New
  23. Fisher, Statistics, and Randomization

    www.statslab.cam.ac.uk/~qz280/talk/fisher-2022/slides.pdf
    3 Jun 2024: Fisher had a “history” with the Soviets.14. 12 C. Reid, Neyman—from life, (Springer-Verlag, New York, 1982), pp.
  24. Multiple conditional randomization tests

    www.statslab.cam.ac.uk/~qz280/talk/mcp-2022/slides.pdf
    3 Jun 2024: How should we resolve this? Our proposal. Use a new term—quasi-randomization tests. ... 2 To provide a unifying framework that incorporates many old and new ideas about multipleconditional randomization tests.
  25. Mendelian Randomization: Old and New Insights Qingyuan Zhao…

    www.statslab.cam.ac.uk/~qz280/talk/penn-biostat-2021/slides.pdf
    3 Jun 2024: Mendelian Randomization: Old and New Insights. Qingyuan Zhao. Statistical Laboratory, University of Cambridge. ... I New life of an old idea:. MR = Base causal inference on randomness in Mendelian inheritance.
  26. CAUSAL INTERPRETATIONS OF BLACK-BOX MODELS QINGYUAN ZHAO AND TREVOR…

    www.statslab.cam.ac.uk/~qz280/publication/pdp/paper.pdf
    3 Jun 2024: Example 6 (Online news popularity dataset4). Fernandes et al. (2015) gathered 39, 797. ... news article published by Mashable and used 58 predictor variables to predict the.
  27. CAUSAL INFERENCE - Example Sheet 2 Solutions J. Hera ...

    www.statslab.cam.ac.uk/~qz280/teaching/causal-2023/S2.pdf
    3 Jun 2024: 7 6, and orient the graph accordingly, see Figure 4. (3) Last, we orient edges to avoid cycles or the introduction of new immoralities.
  28. Observational Studies () Submitted ; Published Selective Inference…

    www.statslab.cam.ac.uk/~qz280/publication/effect-modification-acic/paper.pdf
    3 Jun 2024: of new statistical learning methods that are muchmore powerful at discovering effect modification. ... Small (2018) discussed connections of thisalternative approach to observational studies. The application in effect modification also suggests new
  29. Causal Inference

    www.statslab.cam.ac.uk/~qz280/teaching/causal-2023/slides.pdf
    3 Jun 2024: Do new web designs increase a company’s revenue? Qingyuan Zhao (University of Cambridge) Causal Inference MT2023 9 / 79. ... Review: the squiggly line notationThis new notation is introduced this year to visualize graphical arguments.
  30. Machine Learning meets Biostatistics IIA crash course on Causal ...

    www.statslab.cam.ac.uk/~qz280/talk/ccaim-summer-school-2022/slides.pdf
    3 Jun 2024: Example. Suppose a physician is allowed to administer a promising new drug to 5 out of 10 patients.
  31. Statistical inference in two-sample summary-data Mendelian…

    https://www.statslab.cam.ac.uk/~qz280/publication/mr-raps/
    3 Jun 2024: We find that horizontal pleiotropy is pervasive in MR studies. We propose a new method—robust adjusted profile score—that can consistently estimate the causal effect under pervasive balanced pleiotropy and
  32. www.statslab.cam.ac.uk/~qz280/tag/instrumental-variables/index.xml

    www.statslab.cam.ac.uk/~qz280/tag/instrumental-variables/index.xml
    3 Jun 2024: function</p> <pre><code class="language-R">help(mr.raps) </code></pre> <h3 id="grapple">GRAPPLE</h3> <p>Check out this new R package called <a
  33. BETS: The dangers of selection bias in early analyses ...

    www.statslab.cam.ac.uk/~qz280/talk/ghent-2021/slides.pdf
    3 Jun 2024: The beginning of this project. On December 30, 2019, I saw rumours amout a new SARS-like virus on theinternet.
  34. Causal inference for heritable phenotypic risk factors using…

    https://www.statslab.cam.ac.uk/~qz280/publication/mr-grapple/
    3 Jun 2024: May 2020Abstract. We greatly improve the applicability of MR-RAPS. The new GRAPPLE framework can handle multiple exposures and overlapping exposure and outcomes GWAS, and is able to detect multiple pleiotropic
  35. Reliable Inference for Precision Medicine | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/talk/jsm-2021/
    3 Jun 2024: New Frontiers and Developments in Causal Inference (invited session).
  36. Using sparsity to overcome unmeasured confounding: Two examples |…

    https://www.statslab.cam.ac.uk/~qz280/talk/mrc-bsu-2019/
    3 Jun 2024: I will describe a new statistical framework called Robust Adjusted Profile Score (MR-RAPS) which can provide efficient and robust inference in such problems, by exploiting weak genetic instruments and limiting
  37. Causal-Inference | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/tag/causal-inference/
    3 Jun 2024: A new Bayesian full-information method for life-course Mendelian randomization. We propose a systematic way to select confounders. ... A new approach to sensitivity analysis in linear SEMs using stochastic optimization and the $R2$-calculus.
  38. Using sparsity to overcome unmeasured confounding | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/talk/iscb-2020/
    3 Jun 2024: I will describe a new statistical framework called Robust Adjusted Profile Score (MR-RAPS) which can provide efficient and robust inference in such problems, by exploiting weak genetic instruments and limiting
  39. Randomization | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/tag/randomization/
    3 Jun 2024: A new term---'quasi-randomization test'---is …. What is a randomization test?.
  40. Mendelian-Randomization | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/tag/mendelian-randomization/
    3 Jun 2024: A new Bayesian full-information method for life-course Mendelian randomization. By combining causal graphs and randomization inference, a formal justification for Mendelian randomization is given in the context of ... The idea of MR can be traced back to
  41. Cross-screening in observational studies that test many hypotheses |…

    https://www.statslab.cam.ac.uk/~qz280/publication/cross-screening/
    3 Jun 2024: Qingyuan Zhao, Dylan Small, Paul Rosenbaum. March 2017Abstract. This paper proposes a new method called ‘cross-screening’ to increase the power of sensitivity analysis when multiple causal hypotheses need to be
  42. Resources for Mendelian randomization | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/post/mr-software/
    3 Jun 2024: help(mr.raps). GRAPPLE. Check out this new R package called GRAPPLE that accommodates multiple exposure factors and GWAS sample overlap:.
  43. Multiple Testing | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/tag/multiple-testing/
    3 Jun 2024: This paper proposes a new method called 'cross-screening' to increase the power of sensitivity analysis when multiple causal hypotheses need to be tested simultaneously.
  44. Instrumental-Variables | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/tag/instrumental-variables/
    3 Jun 2024: A new Bayesian full-information method for life-course Mendelian randomization. By combining causal graphs and randomization inference, a formal justification for Mendelian randomization is given in the context of ... We greatly improve the applicability
  45. Talks | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/talk/
    3 Jun 2024: Search. Talks. 2024. Design: The Elusive Principle of Statistics. 2024-03-07 1:00 PM — 2:00 PM University of Oxford. 2024-02-13 2:00 PM — 3:00 PM University of East Anglia. 2024-02-08 2:00 PM — 3:00 PM London School of Economics and Political
  46. Exploratory Data Analysis | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/tag/exploratory-data-analysis/
    3 Jun 2024: The increasing availability and scale of Genome Wide Association Studies (GWAS) bring new horizons for understanding biological mechanisms.
  47. Graphical diagnosis of confounding bias in instrumental variables…

    https://www.statslab.cam.ac.uk/~qz280/publication/iv-diagnosis/
    3 Jun 2024: Qingyuan Zhao, Dylan Small. May 2018Abstract. This research letter proposes a new diagnostic plot for IV analysis, so large bias ratios (compared to OLS estimator) are not over-interpreted when the
  48. What is a randomization test? | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/publication/single-crt/
    3 Jun 2024: A new term—‘quasi-randomization test’—is introduced to define significance tests based on theoretical models and distinguish these tests from the ‘randomization tests’ based on the physical act of randomization.
  49. Research

    www.statslab.cam.ac.uk/~rjs57/Research.html
    21 Jun 2024: Chen, W., Mazumder, R. and Samworth, R. J. (2024) A new computational framework for log-concave density estimation. ... Selected recent talks. Log-concavity: New theory and methodology (Berlin, January 2013) (.pdf, 392K).
  50. PathGPS 1 PathGPS: Discover shared genetic architecture using GWAS ...

    www.statslab.cam.ac.uk/~qz280/publication/pathgps/paper.pdf
    3 Jun 2024: email: hastie@stanford.edu. Summary: The increasing availability and scale of biobanks and “omic” datasets bring new horizons for un-. ... multiple new hypotheses for future investigations. Key words: GWAS; Pathway analysis; Structural equation model;
  51. Randomization Inference | Qingyuan Zhao

    https://www.statslab.cam.ac.uk/~qz280/tag/randomization-inference/
    3 Jun 2024: A new term---'quasi-randomization test'---is …. We propose a general framework for (multiple) conditional randomization tests that incorporate several important ideas in the recent literature. ... This paper proposes a new method called 'cross-screening

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