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13 Mar 2024: We also aim to use DMS to develop new force fields at different scales, such as implicit solvent or coarse-grained models, allowing larger systems to be simulated.

25 Mar 2024: Projects Main applications for October 2024 are now closed. The LMB exceptionally considers applications for research-only MPhil students provided they

23 Feb 2024: Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD) and Amyotrophic Lateral Sclerosis (ALS)

25 Aug 2023: Since the orthogonal ribosome, unlike the natural ribosome, is not essential it is possible to evolve the orthogonal ribosome to read new genetic codes on the orthogonal message. ... This parallel translation pathway provides a series of blank codons

10 Jan 2024: CryoEM at IUCrJ: a new era.

21 Jul 2023: Photographs The LMB has an extensive collection of photographs and images, a selection of which can be viewed here by either browsing the collection or

23 Feb 2024: One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. Search this website. Philipp

16 Feb 2024: Elucidating the molecular details of this pathway was therefore paramount and had the potential to reveal new therapeutic targets for treating cancer.

21 Jul 2023: Mark S. Bretscher Curriculum Vitae Personal Details Date of Birth: 8 January 1940 Family: Married (to Barbara Pearse); one daughter (Nicola) and one son

12 Mar 2024: The brain works as an integrated whole. Animals interact with the world by combining inputs from their senses of vision, hearing, smell, taste, touch and

2 Apr 2024: Search this website. Rising Talent Fellowship. The MRC Laboratory of Molecular Biology (LMB) is proud to launch a new three-year fully funded postdoctoral fellowship for scientists from Black heritage backgrounds. ... This Fellowship is a three-year

23 Feb 2024: Precise chromosome replication is essential for maintaining genome stability, yet the process itself is inherently risky. Duplex DNA must be transiently

5 Mar 2024: Molecular motors have critical roles in the trafficking of organelles, vesicles and macromolecules within the cytoplasm, and aberrant motor function is

23 Feb 2024: Cells are highly compartmentalized into numerous membrane-bound organelles. The membranes that define each organelle contain unique sets of embedded

21 Jul 2023: One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. Search this website. Emeritus.

24 Oct 2023: Joan A. Steitz Postdoc Prize The Max Perutz Fund was set up in June 1980 in honour of the LMB’s founder, Max Perutz, and was established for the promotion

14 Mar 2024: In an effort to better understand human brain development, we have developed a new model system, called cerebral organoids.

23 Feb 2024: One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. Search this website. Chris Tate

18 Mar 2024: Ultimately, mycobacteria can cause granuloma breakdown by inducing programmed macrophage death, a step that further increases bacterial growth and promotes transmission to new hosts. ... Our findings have been borne out in humans and are informing new

23 Feb 2024: Science News : Scientists have mapped an insect brain in greater detail than ever before. ... Sky News : First map of insect brain signals 'big step forward' in understanding thoughts.

21 Jul 2023: Current Vacancies Listed below are the vacancies currently being advertised. In addition we welcome speculative applications from postdocs – see Postdoc

22 Mar 2024: Thus, understanding their cell biology requires re-thinking some of our most basic assumptions (bilayers membranes) and the development of new research tools and methods (high-temperature live cell imaging).

23 Feb 2024: Information transfer in the nervous system occurs at synapses, where presynaptic signals are interpreted by postsynaptic receptors. We study this process

24 Oct 2023: Perutz Student Prize The Perutz Student Prize is awarded annually for outstanding work performed at LMB prior to the award of a Ph.D. Nominees

21 Jul 2023: For a list of recent news items please see the LMB News section.

24 Oct 2023: Eileen Southgate Prize The Max Perutz Fund was set up in June 1980 in honour of the LMB’s founder, Max Perutz, and was established for the promotion

29 Jan 2024: Dendritic cells (DCs) play a key role in initiation of cytotoxic immune responses against pathogens and tumours. In order to prime the relevant T cells,

21 Jul 2023: The LMB moved into a new, modern building in February 2013, on the Cambridge Biomedical Campus. ... A new type of immune cell, that can initiate allergic asthma, has been found.

23 Feb 2024: Our research is aimed at understanding the mechanisms and regulation of chromosome segregation in mitosis. During the cell cycle, accurate chromosome

21 Jul 2023: Since retirement in 2010 he has been working part-time in the University of Strathclyde on new types of microscope, using his ‘Mesolens’ and collaborating in published work on nonlinear optics

14 Mar 2024: Andrew Travers started his Ph.D. at the LMB under the tutelage of the late John Smith in 1964. After this he took a couple of years out as a post-doc in

21 Jul 2023: Group Leader Profiles   Group Leaders are drawn to the LMB from all over the world, having gained experience in a variety of places. Some join the

4 Jul 2023: New members are elected annually by the existing membership. At the LMB, Katja investigates the mechanisms that transform epithelial sheets of cells into complex, three-dimensional organs. ... I am grateful to my past and current lab members for helping

21 Jul 2023: The MRC, realising the potential for medical applications of these developments, provided a new building for the unit, and in 1962 the Laboratory of Molecular Biology was opened. ... Since then, the Laboratory has been a prolific source of new ideas,

21 Jul 2023: In conjunction with Professor Matthew Wood and colleagues at the University of Oxford, we designed a new class of cell-penetrating peptides, called Pip, which showed outstanding cell and in vivo ... The new D-PEP peptides form the basis of founding of a

21 Jul 2023: Scientific Training Electron Microscopy Biophysics Macromolecular Crystallisation Crystallography Course 2013 Statistics Course 2014 RNA-seq course

23 Feb 2024: We are interested in cell autonomous innate immunity, i.e. in the ability of individual cells to defend themselves against infection. Cytosolic defence

23 Feb 2024: Splicing of precursor messenger RNA (pre-mRNA) is a ubiquitous hallmark of gene expression in all eukaryotes. Within the cell, splicing occurs

1 Feb 2024: Design of the new building. In keeping with the original ethos of the LMB, the building has an open plan design with many communal areas to encourage interactions and discussions between ... The LMB has a number of initiatives to help employees save

13 Feb 2024: Neuronal circuits are the biological substrates for all aspects of brain function such as learning, memory, thought, speech and consciousness. The

7 Sep 2023: Using techniques including mouse genetics, fluorescence imaging and gene expression analysis we discovered group 2 innate lymphoid cells (ILC2s) as significant new participants in immune regulation through their cytokine secretion (Figure

11 Mar 2024: Marta Shahbazi, Group Leader in the LMB’s Cell Biology Division, has been announced as one of the 2024 recipients in the Life Sciences category.

25 Aug 2023: Deorphanisation of novel biogenic amine-gated ion channels identifies a new serotonin receptor for learning..

1 Feb 2024: In 2013, the LMB moved to a new, purpose-built building designed to deliver the right environment in which innovative medical research, translation and collaboration can flourish. ... Both new and established researchers are encouraged to utilise the

22 Mar 2024: Molecular Immunity Unit Menna Clatworthy LMB Division - Molecular Immunity Unit The Clatworthy lab is interested in understanding how B cell activation

21 Jul 2023: modeling. These studies offer new approaches for tackling the challenge of antibiotic resistance.

2 Feb 2024: Cell shape is adapted to function. Organelle shape and local membrane architectures are likewise optimised for the processes that take place on and within

21 Jul 2023: In 1969 Brenner and Crick invited him to the LMB to their new Cell Biology division.

21 Jul 2023: By using such a tractable model system, we can rapidly discover new pathways and dissect mechanisms that may be directly relevant to a number of human diseases, most notably cystic fibrosis ... We use high throughput yeast genetics to identify new

9 Aug 2023: Technician Commitment The LMB became a signatory of the Technician Commitment in November 2022.  We employ over 150 technical staff in a wide