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18 Jun 2021: We expect to test new compounds that inhibit alpha-synuclein aggregation into clumps and spreading to delay the development of pathology. ... Several collaborations are in place and will be developed to obtain new tools to further the understanding of

13 Sep 2021: All new information will be presented at scientific conferences and published as peer-reviewed research articles. ... When repeated or prolonged interventions are required, animals will be acclimitised to new environments (e.g.

18 Jun 2021: We are using new-born mice to collect cells to grow and keep in a dish to do experiments. ... provide additional sources of new recommendations and advances in animal techniques and clinically applicable models.

19 Aug 2021: Animals from these new lines will be used to generate eggs by natural spawning. ... In the case of new chemicals, pilot experiments will be used to test chemical toxicity.

13 Sep 2021: The work will;. 1. Provide new insights into the mechanisms required for regeneration. ... Thus, animal experiments are essential to understand regulatory mechanisms and to design and test potential new therapies.

18 Jun 2021: Chiefly, we are interested in developing new understanding of nutrient signalling (e.g. ... As such, our work may highlight new uses for existing compounds or indicate new targets for future compounds.

13 Sep 2021: Hence, there is an urgent need for new and safe drugs that successfully reverses or prevents progression of liver injury in patients with NASH. ... Page 4 of 7. By researching on new targets for such related diseases is a clear unmet clinical need.

13 Sep 2021: fostering of new international collaborations that will allow new approaches to current and future scientific questions. - ... Subsequently, the new mouse line would be used to obtain embryos for the experiments as described above.

19 Aug 2021: Page 2 of 9. What's the aim of this project? Our aim is to identify and validate new mechanisms for treating dementia, to identify novel, drug-like compounds that work ... Who or what will benefit from these outputs, and how? Data on new drug targets may

13 Sep 2021: It is estimated that by 2040 there will be 27.5 million new cases of cancer each year. ... We ensure small-scale pilot or tolerability studies are carried out for new tumour types, experimental methods, or therapies.

19 Aug 2021: Why is it important to undertake this work? It is important to undertake this work so that we can discover new drugs and better vaccines for treating and preventing many different ... New medicines, namely vaccines and drugs. Drugs that offer potential

3 Mar 2021: from the AWERB Standing Committee to consider the 3Rs sections of some new project licence. ... where new or revisions are necessary to Standard Operating Procedures [SOPs] and implement University.

19 Aug 2021: Similarly, it would not be possible to develop new treatments for brain disorders without testing them in animal models first. ... Thus, our recent work on environmental enrichment has actually shed new light on the rather anthropomorphic view of the

13 Sep 2021: This will create new opportunities to test new therapies that can stop bad inflammation. ... This will also provide us the opportunity to build new collaborations locally and internationally.

13 Sep 2021: By disseminating our observations from early stages, for example via conferences, we create new collaborations with experts in research fields beyond our own. ... Methods and datasets generated in these types of analyses are made publicly available as

18 Jun 2021: D) Development and exploitation. It is possible that potential new treatments will be generated in this project. ... I attend numerous conferences, where new findings are presented, allowing improvements in our techniques and experiments.

20 Aug 2021: Protocol 1: Superovulation. Superovulation is required for generating new transgenic strains, freezing lines, and importing new lines when rederivation is required. ... Protocol 3: Embryo recipient. Embryo recipients are required when thawing embryos

18 Jun 2021: our findings to help develop new strategies to identify, potentially prevent and treat blood cancers. ... Our new animal models, as well as tissues collected from the mice will be valuable to other scientists studying the development of blood cancers.