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18 Jun 2021: We expect to test new compounds that inhibit alpha-synuclein aggregation into clumps and spreading to delay the development of pathology. ... Several collaborations are in place and will be developed to obtain new tools to further the understanding of

13 Sep 2021: All new information will be presented at scientific conferences and published as peer-reviewed research articles. ... When repeated or prolonged interventions are required, animals will be acclimitised to new environments (e.g.

18 Jun 2021: We are using new-born mice to collect cells to grow and keep in a dish to do experiments. ... provide additional sources of new recommendations and advances in animal techniques and clinically applicable models.

19 Aug 2021: Animals from these new lines will be used to generate eggs by natural spawning. ... In the case of new chemicals, pilot experiments will be used to test chemical toxicity.

13 Sep 2021: The work will;. 1. Provide new insights into the mechanisms required for regeneration. ... Thus, animal experiments are essential to understand regulatory mechanisms and to design and test potential new therapies.

18 Jun 2021: Chiefly, we are interested in developing new understanding of nutrient signalling (e.g. ... As such, our work may highlight new uses for existing compounds or indicate new targets for future compounds.

13 Sep 2021: Hence, there is an urgent need for new and safe drugs that successfully reverses or prevents progression of liver injury in patients with NASH. ... Page 4 of 7. By researching on new targets for such related diseases is a clear unmet clinical need.

13 Sep 2021: fostering of new international collaborations that will allow new approaches to current and future scientific questions. - ... Subsequently, the new mouse line would be used to obtain embryos for the experiments as described above.

19 Aug 2021: Page 2 of 9. What's the aim of this project? Our aim is to identify and validate new mechanisms for treating dementia, to identify novel, drug-like compounds that work ... Who or what will benefit from these outputs, and how? Data on new drug targets may

13 Sep 2021: It is estimated that by 2040 there will be 27.5 million new cases of cancer each year. ... We ensure small-scale pilot or tolerability studies are carried out for new tumour types, experimental methods, or therapies.