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Structures of virus-like capsids involved in learning and memory…
https://www2.mrc-lmb.cam.ac.uk/structures-of-virus-like-capsids-involved-in-learning-and-memory-formation/23 Jan 2020: The neuronal gene Arc plays important roles in neural plasticity, learning and memory-related molecular processes and has been shown to mediate intercellular RNA transfer by forming viral-like capsids. John Briggs’ group has now solved the first
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Unravelling the replisome: how a molecular machine overcomes…
https://www2.mrc-lmb.cam.ac.uk/unravelling-the-replisome-how-a-molecular-machine-overcomes-obstacles-to-dna-replication/4 May 2020: to reproduce new double-stranded DNA. ... These processes are tightly coupled by the replisome complex to avoid stretches of exposed single-stranded DNA between the point of unwinding and the point of synthesis of new DNA.
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Tracing a transcription initiation factor’s molecular journey across…
https://www2.mrc-lmb.cam.ac.uk/tracing-a-transcription-initiation-factors-molecular-journey-across-evolutionary-timescale/13 May 2020: M Madan Babu’s group publishes a comprehensive model for the functional innovations of TBP.
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Liz Miller: Signed, sealed, delivered - protein trafficking in the…
https://www2.mrc-lmb.cam.ac.uk/liz-miller-signed-sealed-delivered-protein-trafficking-in-the-endoplasmic-reticulum/13 Oct 2020: After hearing him talk in a new group leaders’ seminar series, Liz realised that her colleague Madan Babu, who works on intrinsically disordered proteins, could help her a lot in understanding ... The job I’ve given myself is to do preliminary
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A splice of life - Chemistry World looks at how structural biology…
https://www2.mrc-lmb.cam.ac.uk/a-splice-of-life-chemistry-world-looks-at-how-structural-biology-has-revealed-the-secrets-of-the-spliceosome/24 Mar 2020: Clare Sansom describes the history of spliceosome research and its importance, focusing on the work of Kiyoshi Nagai and his group. More...
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Emmanuel Levy has been announced as the Blavatnik Awards for Young…
https://www2.mrc-lmb.cam.ac.uk/emmanuel-levy-has-been-announced-as-the-blavatnik-awards-for-young-scientists-in-israel-2020-laureate-in-chemistry/30 Jan 2020: The Blavatnik Awards honour outstanding, innovative scientists at the early stages of their careers. Emmanuel has been recognised for his work on protein
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Inspiring students to think about science in a different way through…
https://www2.mrc-lmb.cam.ac.uk/news-and-events/public-engagement/supporting-education/inspiring-students-to-think-about-science-in-a-different-way-through-dance/21 Feb 2020: the arts and sciences are a really powerful way to reach new audiences.”.
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First complete atomic model of condensin lays foundation for…
https://www2.mrc-lmb.cam.ac.uk/first-complete-atomic-model-of-condensin-lays-foundation-for-understanding-chromosome-compaction/14 Jul 2020: Each of our cells contains about two metres of DNA. To be able to store all of this, the DNA must be very tightly compacted. Jan Löwe’s group have produced the first atomic model of condensin, a complex known to have a role in compacting DNA into
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Cell-invading bacteria are converted into signalling platforms that…
https://www2.mrc-lmb.cam.ac.uk/cell-invading-bacteria-are-converted-into-signalling-platforms-that-may-trigger-septic-shock/15 Jun 2020: Septic shock is a common cause of death that can be triggered by LPS, a component of the outer membrane of some bacteria. Felix Randow’s group has shown how the immune response against cytosol-invading bacteria is activated by a signalling
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LMB participates in UK-wide COVID-19 Protein Portal to provide…
https://www2.mrc-lmb.cam.ac.uk/lmb-participates-in-uk-wide-covid-19-protein-portal-to-provide-essential-reagents-for-sars-cov-2-research/12 May 2020: UK consortium of leading protein production laboratories provide protein reagents for SARS-CoV-2 research for free, in an Open Science initiative led by Wellcome and UKRI.
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Madeline Lancaster: The accidental organoid - mini-brains as models…
https://www2.mrc-lmb.cam.ac.uk/madeline-lancaster-the-accidental-organoid-mini-brains-as-models-for-human-brain-development/11 Feb 2020: As a very new postdoc in Jürgen Knoblich’s lab in Vienna, she was trying to get mouse neural epithelial cells to form neural rosettes, but couldn’t get the cells ... LMB trusts me to think about these questions is great.” And she’s not felt
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Cryo-EM Model-Buildingwith Modern Coot Paul Emsley@ Ben Gurion…
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/coot-2020-nov-slac.pdf10 Nov 2020: Where does Cryo-EM Coot fit into the various builds/releases? What's new in 0.9 and how does it help? – -
LMB Band 5 - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/research/animal-research/lmb-band-5/21 Feb 2020: One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. Search this website. LMB Band
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Impress
https://www2.mrc-lmb.cam.ac.uk/coot/ephemera/beyond-coloured-lines.pdf28 Sep 2020: how depth is represented in 3D applications– problems with the current representation– Screenshots: how New Coot is an improvement on Old Coot. ... Ambient New Lighting Model:. – Ambient, Diffuse, Specular, Fresnel, Ambient Occlusion– Not yet: -
MD1-118 Hippocrates additive screen
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/WWWrobots/LMB%20plates/Addit-03.pdf13 Oct 2020: The Hippocrates Additive Screen is a new 48-condition additive screen, containing a library of unique drug-like compounds to enhance protein stability and crystallisability. -
EMBO Practical Course on the Crystallization of Macromolecular…
https://www2.mrc-lmb.cam.ac.uk/groups/cartera/download/cv/2020_01_Carter_CV.pdf31 Jan 2020: HONOURS AND AWARDS: Apr 2018 Wellcome Investigator Award May 2016 EMBO Membership Dec 2012 Wellcome Trust New Investigator Award Nov 2012 EMBO Young Investigator Program Oct 2010 Elected Fellow of Clare ... Curriculum vitae. Other activities 2020 -
Carter lab dynactin prep from frozen porcine brains, using ...
https://www2.mrc-lmb.cam.ac.uk/groups/cartera/download/2020_Carter_dynactin_brain_prep.docx28 Feb 2020: Get one new zip lock bag per brain, and open them so that they are easy to handle with dirty hands later on. ... Put brain in new zip lock bag and wash in PBS. -
rq5005
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/iucrjS20.pdf28 Jul 2020: L. D. & Kirshner, D. A. (1971). Nature New Biol. 231,. -
31/10/2018 Carter lab TIRF microscopy Single Molecule Assay 5x ...
https://www2.mrc-lmb.cam.ac.uk/groups/cartera/download/resources/protocols/2020_Carter_TIRF_protocol.docx28 Jan 2020: After 3 hours or so, make a new dilution. Consider also spinning the 250 µL stock if background is still high. -
FtsK in motion reveals its mechanism for double-stranded DNA…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/FtsK_Jean_2020_PNAS.pdf8 Jun 2020: J. Begg, S. J. Dewar, W. D. Donachie, A new Escherichia coli cell division gene, ftsK. ... Nucleic Acids Res. 32, 5260–5279 (2004). 28. J. Zivanov et al., New tools for automated high-resolution cryo-EM structure de-termination in RELION-3. -
The structure of human thyroglobulin
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/TG_Nature2020.pdf31 Jan 2020: Struct. Biol. 180, 519–530 (2012). 35. Zivanov, J. et al. New tools for automated high-resolution cryo-EM structure determination in RELION-3. -
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https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Collier_2020_elife-59560-v1.pdf15 Sep 2020: association with Smc1’s ATPase head and the coiled coil emerging from Smc3’s head creates a new. -
Clockology Survey Thank you for your interest in participating ...
https://www2.mrc-lmb.cam.ac.uk/groups/oneill/wp-content/uploads/sites/24/Clockology-Survey-FINAL_14_07_2020_COMBINED.docx14 Jul 2020: The phase before the stimulus is plotted against the difference between the new phase and the old phase. ... Phase transition curve: a curve describing the relationship between the circadian phase at which a stimulus is applied and the resultant new -
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https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2020/09/eLife_2020.pdf12 Jun 2020: For correspondence:. rhegde@mrc-lmb.cam.ac.uk. †These authors contributed. equally to this work. Competing interest: See. page 25. Funding: See page 25. Received: 15 April 2020. Accepted: 26 May 2020. Published: 27 May 2020. Reviewing editor: -
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https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2020/09/eLife_2020b.pdf24 Jul 2020: For correspondence:. rhegde@mrc-lmb.cam.ac.uk. †These authors contributed. equally to this work. Competing interest: See. page 25. Funding: See page 25. Received: 15 June 2020. Accepted: 10 July 2020. Published: 13 July 2020. Reviewing editor:
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