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10 Nov 2019: It’s not every day a steam train goes past the LMB. Day 314 of #LMB365 shows the 61306 Mayflower on a recent trip from London. Mayflower is a B1 Class locomotive and was built in 1948 by the North British Locomotive Company in Glasgow for the

8 Mar 2019: As predicted #LMBees are exploring the building and have made it as far as the LMB's Media Prep Department. As can be see on day 68 of #LMB365, they searched through pre-prepared solutions until they found something sweet. Hopefully they have left

10 Sep 2019: As the model organismC. elegansis transparent we can use it to look at subcellular organelles and use fluorescent protein tags to study different processes. This image for day 253 of #LMB365 shows two different organelles labelled with green and

8 Aug 2019: This image for day 220 of #LMB365 shows a digitalized patch of cells within the Drosophila melanogaster embryo. Cell-to-cell interfaces are randomly coloured and cell centroids are depicted with a square. Image by Yara Sanchez-Corrales in Katja

25 Jan 2019: Day 25 of #LMB365 is a close up of the fruit fly Drosophila Melanogaster. These are used to study development in the group of @katjaroeper in Cell Biology @CellBiol_MRCLMB. These fluorescent flies in their cage lay GFP-expressing embryos which are

28 Aug 2019: Ketan Malhotra from Anne Bertolotti’s group and Manuel Carminati from Lori Passmore’s group recently prepped 62 litres of E.coli to harvest their protein for purification and structure determination. Day 240 of #LMB365 shows the resulting 50 ml

9 May 2019: This picture for day 130 of #LMB365 by Thomas Mund shows a confocal image of the GFP-stained cytoskeletal remnants of a HeLa cell, an immortal cell line used in scientific research at the LMB. Sometimes beauty lies beyond what you are originally

18 Sep 2019: Every year or so the LMB takes a group photo of all the current PhD students. Photos in the LMB Archive go back to at least the 1990's. Day 261 of #LMB365 shows the current cohort posing for this year’s photo – watch this space for the actual

2 Jan 2019: On Day 2 of #LMB365 we have a beautiful image by Katja Roeper @katjaroeper in the Cell Biology Division @CellBiol_MRCLMB showing an epithelial Caco2 cell monolayer labelled for a tight junction protein in blue and nuclei in red. Her lab uses this

29 Apr 2019: On day 120 of #LMB365 we find some LMB PhD students “relaxing” by bouldering at a local climbing centre after a long day in the lab. Abilities varied, but they all enjoyed themselves and ended up with a well-deserved pint in a local pub.

7 Aug 2019: Stands the church clock at ten to three. And is there honey still for tea? On Day 219 of #LMB365 are some of the first jars of honey produced this year from the #LMBee. 60 jars went on sale to staff and sold out within a couple of hours

9 Jul 2019: Day 190 of #LMB365 shows some plastic measuring cylinders. There are over 1200 cylinders in cupboards across the LMB ranging from 10ml to 2litres. These are washed and replaced by the Glasswash Team on a daily basis & without their dedication LMB

13 Mar 2019: Day 73 of #LMB365 brings you a group photograph of the MRC Council who held their recent meeting here at the LMB. The MRC Council is responsible for advising the MRC Executive Chair and making decisions, as delegated to it by the UKRI Board, on

4 Jan 2019: Microscopes at the ready on day 4 of #LMB365. These microscopes are used in the Cell Biology Division @CellBiol_MRCLMB for looking at Dictyostelium discoideum, a species of soil-living amoeba, which is one of the model organisms used at the LMB.

13 Jan 2019: Day 13 of #LMB365 celebrates LMB Nobel Laureate @NobelPrize Sydney Brenner. Born on this day in 1927 in South Africa, he was jointly awarded the Nobel Prize for Physiology or Medicine in 2002 for discoveries concerning the genetic regulation of

19 Oct 2019: Day 292 of #LMB365 from Laura Pellegrini in Madeline Lancaster’s group shows a section of a cerebral organoid including a ventricular lobe, resembling the structure of the developing human cortex. It also shows an epithelial tissue named the

20 Sep 2019: Much of the research at the LMB must be conducted in carefully controlled conditions of temperature, vibration and magnetic fields. The Electronics Workshop works with Group Leaders to detect and analyse extremely small sources of potential

26 Aug 2019: Day 238 of #LMB365 shows a cerebral organoid ventricle labelled with markers of neuroepithelial cells, neuronal progenitors and neurons from Laura Pellegrini in Madeline Lancaster’s group in Cell Biology. The complex structural organisation of

11 May 2019: The LMB’s Tissue Culture Lab prepares big batches of Earle's Balanced Salt Solution for trypsin. The solution seen being prepared on day 132 of #LMB365 will be used all around the building to dissociate adherent cells from the vessel in which they

19 Mar 2019: This drawing for day 79 of #LMB365 is by Paul Margiotta #piljammin in the LMB’s Visual Aids team. It is an abstract interpretation of the LMB's use of X-rays to reveal hitherto undefined protein structures overlaid with the period feel of the film

13 Aug 2019: On day 225 of #LMB365 is Fred Sanger who was born #OTD in 1918. He is the only Briton to have been awarded two @Nobel prizes and the only scientist to

26 Jul 2019: On day 207 of #LMB365, the LMBee has been exploring the wonderful LMB Archive. The Archive has a diverse collection of resources and information about the LMB, its science and people. Here, the LMBee sits in one of the display cabinets, amongst a

9 Jan 2019: On day 9 of #LMB365 we have an image by @katjaroeper in Cell Biology @CellBiol_MRCLMB of a Drosophila embryo viewed during the process of dorsal closure. Katja’s group uses Drosophila to understand organ formation and the cell-cell adhesion

24 Oct 2019: Day 297 of #LMB365 is a screenshot from our internal “Bee Cam”. It shows our resident beekeeper Geoff putting on a feeder of sugar syrup for the LMB’s bees to build up stores for the winter. The bees have also been treated for mites so

2 Oct 2019: LMB scientists visited Ely Cathedral for LifeLab last weekend to talk to members of the public about their research on the origin of life and about how cryo-EM works. On day 275 of #LMB365, we see some LMB volunteers carrying the backdrop of the

15 Dec 2019: Day 349 of #LMB365 shows some of the LMB’s dedicated crafters running their Christmas stall to raise funds for the Cystic Fibrosis Trust. Many of the items for sale were crocheted, knitted or embroidered and members of the LMB purchased lots of

3 Dec 2019: Day 337 of #LMB365 shows this year’s PhD student photo featuring most of the current students, together with the LMB Director, Director of Studies, Postgraduate Administrator and Assistant. The LMB students are a diverse group and come from over

11 Jan 2019: John Sutherland's group in the PNAC Division is trying to recreate the steps that led to life and took place on Earth 4.5 billion years ago. In day 11 of #LMB365 we see a pair of flasks in which components of potentially primitive genetic materials

16 Apr 2019: Georges Kohler was born on this day in 1946, in Munich, Germany. On day 107 of #LMB365 he is pictured with César Milstein. Georges and César were awarded the Nobel Prize for Physiology or Medicine in 1984, for their work on the principle for

17 Sep 2019: Day 260 of #LMB365 shows Michael Fuller, who was born on this day in 1936. He served the LMB for over 44 years, as apprentice technician, Steward, Laboratory Services Manager and Special Projects Co-ordinator. This photo, taken at Venki

27 May 2019: On this day in 1962, HM The Queen officially opened the first LMB building. For day 148 of #LMB365, The Queen is seen arriving at the entrance to the LMB. Max Perutz, in the foreground, greets The Queen, while LMB staff inside the building can be

27 Jun 2019: LMB researchers will be telling the public about their work on the origin of life at The Royal Society Summer Science Exhibition. On day 178 of #LMB365 we see Phil Holliger being interviewed about the exhibition. Learn more about our exhibit at https

13 Feb 2019: Day 45 of #LMB365 is a ventricular zone of a cerebral organoid labelled for neuronal progenitors and cells in division. This was taken by Laura Pellegrini from Madeline Lancaster’s group in the Cell Biology Division. The cerebral organoids

18 Apr 2019: The image for day 109 of #LMB365 is provided by Ben Sutcliffe in the LMB’s Light Microscopy Facility. When they need to align the laser on the custom mSPIM light sheet microscope they use a solution of highlighter pen in water so that they can see

16 May 2019: In this image for day 137 of #LMB365 seam cells are highlighted in green in the middle of a young (larval) C. elegans worm. The seam cells act like stem cells and during larval development these cells undergo asymmetrical divisions and either

27 Feb 2019: On day 59 of #LMB365 we have a close-up of a large scale oligonucleotide synthesiser used by John Sutherland’s group in the LMB’s PNAC Division to make sufficient amounts of RNA oligonucleotides for NMR experiments to investigate the sort of

8 May 2019: Day 129 of #LMB365 shows Michael Levitt when he joined the scientific staff at the LMB in 1974. Michael was born on this day in 1947, in Pretoria, South Africa. He was awarded the Nobel Prize in Chemistry in 2013 for the development of multiscale

30 Jul 2019: Day 211 of #LMB365 shows a cerebral organoid section with large ventricles from Laura Pellegrini in Madeline Lancaster’s group in Cell Biology. Cell nuclei are labelled in blue and the apical marker ZO1 in white highlights the perimeter of the

3 Jun 2019: On day 155 of #LMB365 it appears the LMB bees have been busy. This is a honey frame from one of our hives two thirds full and capped over. Once full this can be extracted and the honey bottled ready for use. We hope to have LMB honey available

6 Jul 2019: PhD students at the LMB are registered with the University of Cambridge, and are therefore automatically members of a college. This photo for day 187 of #LMB365 shows members of Bill Schafer’s lab celebrating the end of another day in the LMB by

10 Dec 2019: On this day each year the Nobel Prize award ceremony and banquet is held. To celebrate this, day 344 of #LMB365 shows a very rare collection of Nobel Prize Medals awarded to members of the LMB, together with champagne bottles signed by some Nobel

14 Oct 2019: On day 287 of #LMB365 we see an image of a bee’s leg taken by a pupil at Stapleford Primary School and submitted for the LMB’s 2019 Science Image Award. We’re now starting to recruit nearby primary schools for next year’s competition

20 Jul 2019: A crocheted stag’s head looks out into the atrium on day 201 of #LMB365 giving a glimpse of this years Art and Craft show. The annual event gives staff at the LMB a chance to showcase their artistic and creative talents and for others to see a

30 Dec 2019: In quieter moments between experiments, members of the LMB have had fun recreating some of our state-of-the art equipment in Lego®, as seen here on day 364 of #LMB365. This includes an NMR machine, AKTA, orbitrap mass spec and a transmission

25 Apr 2019: This image for day 116 of #LMB365 is a dish of negatively stained grids, discarded after use in the general-use Spirit, which is a 120 kV transmission electron microscope (TEM). Samples are applied to the grid, then surrounded by heavy metal stain

25 Jan 2019: In 1971, he was recruited to the LMB by Max Perutz to set up and head a new Sub-Division of Peptide Chemistry. ... The aim was to research and develop new methods for the partial and total synthesis of peptides and proteins.

29 Mar 2019: The image for day 89 of #LMB365 is provided by Oleksiy Kovtun. This EM image shows phage particles tangled in bacterial flagella. Bacteria are used as a protein expression host to allow the purification of large amounts of the protein of interest,

19 Sep 2019: Day 262 of #LMB365 shows a confocal image of a gravid Caenorhabditis elegansworm from Ranya Behbehani in Rebecca Taylor’s lab in the Neurobiology Division. This model organism has been used at the LMB for many years since the initial studies on

14 Oct 2019: 2019/Jan Lab homepage's updated! (Check out our new publications & members etc). ... 2017/Sep A new PhD student's just joined our lab! Welcome, Eva!

14 Oct 2019: Toggle nav. Coming soon! Group photo in Director's office at MRC-LMB (Dec). Kristin & Denise received MRC's public engagement award (Dec) -Rhianna's farewell party (Aug). Lab summer BBQ (July). Group photo at MRC-LMB (June).