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2 Feb 2004: Membrane transport between compartments in eukary-otic cells requires proteins that allow the budding andSCISSION of nascent cargo vesicles from one compartmentand their targeting and fusion with another. Just asSNARES are proposed to be essential

23 Nov 2004: W, FxDxF, WVxF and a new FxxFxxL motif), we can now. ... but a number of new ligands including the HIV-1 Rev inter-.

15 Jan 2004: Therefore, we employed two new ap-proaches. First, we took advantage of the ability of PTA todifferentially precipitate PrPSc while leaving PrPC in the super-natant fraction. ... ity of this model system, until now. Selective precipitation ofPrPSc(P101L)

29 Dec 2004: G., eds) Vol. 17, pp. 312-362, Academic Press, New York. Beam, K.

21 Dec 2004: Treatment of cell lysateswith peptide:N-glycosidase and endoglycosidase H (both from New EnglandBiolabs, Beverly, MA) was performed as recommended by the manufacturer.Pulse labeling was performed in six-well dishes

8 Nov 2004: Protection from cytosolic prion protein toxicityby modulation of protein translocation. Neena S Rane, Jesse L Yonkovich andRamanujan S Hegde. Cell Biology and Metabolism Branch, NICHD, National Institutesof Health, Bethesda, MD, USA. Failure to

15 Apr 2004: This ap-proach was subsequently exploited to provide new insightsinto both the composition and organizational state of thetranslocon during its functional cycle in cells. ... Pactamycin also inhibits new proteinsynthesis within 5 min, but as expected for

6 Dec 2004: A new mech-anism is shown whereby dynamin causes fission of the intact fusedvesicle before collapse and intermixing with the plasma membrane.v-SNARE, vesicle SNARE; t-SNARE, target SNARE.